Daniela Marhofer
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View article: Intestinal Reconstruction in Infants Under Epidural Anesthesia Without Invasive Airway: A Prospective Case Study
Intestinal Reconstruction in Infants Under Epidural Anesthesia Without Invasive Airway: A Prospective Case Study Open
Background and Aims: This study explored the feasibility of performing intestinal reconstruction after enterostomy in infants using ultrasound-guided epidural anesthesia with sedation, aiming to avoid invasive airway manipulation and the u…
View article: Liposomal Bupivacaine for Peripheral Nerve Blockade: A Randomized, Controlled, Crossover, Triple-blinded Pharmacodynamic Study in Volunteers
Liposomal Bupivacaine for Peripheral Nerve Blockade: A Randomized, Controlled, Crossover, Triple-blinded Pharmacodynamic Study in Volunteers Open
Background Little is known about the pharmacodynamic characteristics of liposomal bupivacaine. Hypothesizing that they would not identify pharmacodynamic differences from plain bupivacaine during the initial period after administration, bu…
View article: The impact of biological sex in peripheral nerve blockade: A prospective pharmacodynamic, pharmacokinetic and morphometric study in volunteers
The impact of biological sex in peripheral nerve blockade: A prospective pharmacodynamic, pharmacokinetic and morphometric study in volunteers Open
Study objective The impact of biological sex in peripheral regional anaesthesia is largely unknown. We therefore designed a prospective study in volunteers to investigate the impact of biological sex on pharmacodynamic, pharmacokinetic and…
View article: Ultrasound-Guided Dorsal Penile Nerve Block in Children: An Anatomical-Based Observational Study of a New Anesthesia Technique
Ultrasound-Guided Dorsal Penile Nerve Block in Children: An Anatomical-Based Observational Study of a New Anesthesia Technique Open
Dorsal penile nerve block stands out as one of the commonly employed regional anesthetic techniques in children. Despite the large body of experience, failure rates are still significant. We included 20 children (median (SD) age of 73 (31)…
View article: Sex differences in pediatric caudal epidural anesthesia under sedation without primary airway instrumentation
Sex differences in pediatric caudal epidural anesthesia under sedation without primary airway instrumentation Open
Study objective To identify sex differences associated with caudal epidurals, the most commonly used technique of pediatric regional anesthesia, based on individually validated data of ultrasound-guided blocks performed between 04/2014 and…
View article: ADV6209 for Premedication in Pediatric Anesthesia: A Double-Blinded, Randomized Controlled Trial
ADV6209 for Premedication in Pediatric Anesthesia: A Double-Blinded, Randomized Controlled Trial Open
ADV6209, a new formulation of midazolam with the addition of γ-cyclodextrin for oral use, has recently been licensed as the first pediatric sedative in the European Union. We compared the clinical efficacy of ADV6209 to the standard formul…
View article: Pharmacokinetics of doripenem in plasma and epithelial lining fluid (ELF): comparison of two dosage regimens
Pharmacokinetics of doripenem in plasma and epithelial lining fluid (ELF): comparison of two dosage regimens Open
The difference in plasma pharmacokinetics after 1-h and 4-h infusion reflects in the concentration versus time profile in the lung, but concentration at the target site was not only considerably lower but also subject to high inter-individ…
View article: Pharmacokinetics of Cefuroxime in Synovial Fluid
Pharmacokinetics of Cefuroxime in Synovial Fluid Open
Cefuroxime is frequently used as preoperative antibiotic prophylaxis and may be used for the treatment of septic arthritis. A prerequisite for successful treatment of septic arthritis is the ability of an antibiotic agent to penetrate into…
View article: Penetration of linezolid into synovial fluid and muscle tissue after elective arthroscopy
Penetration of linezolid into synovial fluid and muscle tissue after elective arthroscopy Open
Linezolid may be used to treat septic arthritis caused by bacterial strains with an MIC ≤1 mg/L. Assuming a pharmacokinetic/pharmacodynamic target of > 50 for AUC0-24/MIC, when treating strains with an MIC >1 mg/L treatment surveillance is…
View article: An observational study of the macro‐ and micro‐haemodynamic implications of epidural anaesthesia in children
An observational study of the macro‐ and micro‐haemodynamic implications of epidural anaesthesia in children Open
Summary The haemodynamic implications of epidural anaesthesia in children are poorly documented. We report macro‐ and micro‐haemodynamic data from an observational study of 25 children ranging from neonates to six‐years old, who underwent …