Daniela Murtas
YOU?
Author Swipe
View article: Xanthine Oxidase-Dependent Activation of NLPR3 Inflammasome in Epithelial Cells Sustains Inflammation in Inflammatory Bowel Disease
Xanthine Oxidase-Dependent Activation of NLPR3 Inflammasome in Epithelial Cells Sustains Inflammation in Inflammatory Bowel Disease Open
Importance and Objective Xanthine oxidase (XO) plays a key role in purine metabolism, catalyzing the oxidation of hypoxanthine to xanthine, and xanthine to uric acid (UA) with the production of superoxide anions. The accumulation of UA has…
View article: The translational power of Alzheimer’s-based organoid models in personalized medicine: an integrated biological and digital approach embodying patient clinical history
The translational power of Alzheimer’s-based organoid models in personalized medicine: an integrated biological and digital approach embodying patient clinical history Open
Alzheimer’s disease (AD) is a complex neurodegenerative condition characterized by a multifaceted interplay of genetic, environmental, and pathological factors. Traditional diagnostic and research methods, including neuropsychological asse…
View article: P011 Altered Expression and Enzymatic Activity of Xanthine Oxidase in Inflammatory Bowel Disease
P011 Altered Expression and Enzymatic Activity of Xanthine Oxidase in Inflammatory Bowel Disease Open
Background Xanthine oxidase (XO) is involved in the last steps of purine metabolism; indeed, it catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid (UA) with the production of superoxide anion. The accumulation of…
View article: Prostate‐specific antigen: An unfamiliar protein in the human salivary glands
Prostate‐specific antigen: An unfamiliar protein in the human salivary glands Open
Objectives The presence of prostate‐specific antigen (PSA) in saliva and salivary glands has been reported. Nevertheless, its release pathway in these glands remains to be elucidated. Here, we showed PSA subcellular distribution focusing o…
View article: Synergic Action of Insulin-like Growth Factor-2 and miRNA-483 in Pterygium Pathogenesis
Synergic Action of Insulin-like Growth Factor-2 and miRNA-483 in Pterygium Pathogenesis Open
Pterygium is a multifactorial disease in which UV-B is speculated to play a key role by inducing oxidative stress and phototoxic DNA damage. In search for candidate molecules that are useful for justifying the intense epithelial proliferat…
View article: SmartFlare<sup>TM</sup> is a reliable method for assessing mRNA expression in single neural stem cells
SmartFlare<sup>TM</sup> is a reliable method for assessing mRNA expression in single neural stem cells Open
SmartFlareTM appears to be a reliable, easy-to-handle tool for investigating CD133 and OCT4 expression in a neural stem cell model, preserving cell biological properties in anticipation of downstream experiments.
View article: Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies
Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies Open
Cutaneous melanoma is an aggressive tumor responsible for 90% of mortality related to skin cancer. In the recent years, the discovery of driving mutations in melanoma has led to better treatment approaches. The last decade has seen a genom…
View article: MicroRNAs at the Crossroad of the Dichotomic Pathway Cell Death vs. Stemness in Neural Somatic and Cancer Stem Cells: Implications and Therapeutic Strategies
MicroRNAs at the Crossroad of the Dichotomic Pathway Cell Death vs. Stemness in Neural Somatic and Cancer Stem Cells: Implications and Therapeutic Strategies Open
Stemness and apoptosis may highlight the dichotomy between regeneration and demise in the complex pathway proceeding from ontogenesis to the end of life. In the last few years, the concept has emerged that the same microRNAs (miRNAs) can b…
View article: Absence of Polyphenol Oxidase in Cynomorium coccineum, a Widespread Holoparasitic Plant
Absence of Polyphenol Oxidase in Cynomorium coccineum, a Widespread Holoparasitic Plant Open
Polyphenol oxidase (PPO, E.C. 1.14.18.1) is a nearly ubiquitous enzyme that is widely distributed among organisms. Despite its widespread distribution, the role of PPO in plants has not been thoroughly elucidated. In this study, we report …
View article: Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated
Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated Open
BACKGROUND. Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation. METHODS. DNA and RNA muta…
View article: Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated
Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated Open
Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation. DNA and RNA mutation status were asse…
View article: MicroRNA Signature in Human Normal and Tumoral Neural Stem Cells
MicroRNA Signature in Human Normal and Tumoral Neural Stem Cells Open
MicroRNAs, also called miRNAs or simply miR-, represent a unique class of non-coding RNAs that have gained exponential interest during recent years because of their determinant involvement in regulating the expression of several genes. Des…
View article: Ossification into the osteo‐nevus of Nanta: an interpretative insight
Ossification into the osteo‐nevus of Nanta: an interpretative insight Open
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
View article: Immunophenotypic characterization of telocyte-like cells in pterygium.
Immunophenotypic characterization of telocyte-like cells in pterygium. Open
Because of the distribution and immunophenotype, TCs in pterygium may represent a subpopulation of relatively immature cells with regenerative potential. In addition, the expression of nestin may suggest possible involvement of TCs as acti…
View article: Vitamin D and vitamin D receptor in patients with ophthalmic pterygium
Vitamin D and vitamin D receptor in patients with ophthalmic pterygium Open
Pterygium, an ultraviolet radiation (UV)-related disease, is a relatively benign process, but since it displays tumor-like features, it has been proposed to be a neoplastic- like growth disorder. Vitamin D performs a number of functions in…
View article: Identification of telocytes in the lamina propria of pterygium: an immunohistochemical and transmission electron microscopy study
Identification of telocytes in the lamina propria of pterygium: an immunohistochemical and transmission electron microscopy study Open
Telocytes (TCs) are a novel type of interstitial cells already described in many tissues and organs (1). The name of these cells derives from their typical thin, long processes called telopodes (Tps). Since previous study provided evidence…
View article: Morphologic, immunophenotypic, and ultrastructural characterization of telocytes in pterygium
Morphologic, immunophenotypic, and ultrastructural characterization of telocytes in pterygium Open
Telocytes (TCs) are a novel and peculiar interstitial cell type already described in many tissues and organs. Their name derives from their typical extremely long, thin, tortuous, and overlapping processes called telopodes (Tps), forming a…
View article: Immunohistochemical study of the expression of N-cadherin in cutaneous melanoma and in dysplastic melanocytic nevi
Immunohistochemical study of the expression of N-cadherin in cutaneous melanoma and in dysplastic melanocytic nevi Open
It has been suggested that the invasive and metastatic potential of melanoma cells reflects their ability to undergo epithelial-mesenchymal transition (EMT)-like phenotypic changes (1). Important hallmarks of EMT include the loss of E-cadh…
View article: Immunohistochemical detection of Vitamin D receptor in pterygium
Immunohistochemical detection of Vitamin D receptor in pterygium Open
Pterygium is a chronic condition characterized by the encroachment of altered conjunctiva into the normal cornea. Several factors have been proposed as causative agents in the development of pterygium, however the exact mechanism of its pa…