Daniela Pagnozzi
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View article: Consumption of traditional Sardinian fermented milk promotes changes in the rat gut microbiota composition and functions
Consumption of traditional Sardinian fermented milk promotes changes in the rat gut microbiota composition and functions Open
Our integrated multi-omics approach reveals that dietary supplementation with the traditional Sardinian fermented milk, casu axedu, induces significant shifts in the rat gut microbiota composition and function, characterized by the enrichm…
View article: Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli
Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli Open
Background Innovative antibiotic discovery strategies are urgently needed to successfully combat infections caused by multi-drug-resistant bacteria. Methods We employed a direct screening approach to identify compounds with antimicrobial a…
View article: Comparative proteomics analysis of MRSA under different experimental conditions
Comparative proteomics analysis of MRSA under different experimental conditions Open
The ability of methicillin-resistant Staphylococcus aureus (MRSA) to adapt to environmental stressors is crucial for its survival and persistence. This study used shotgun proteomics to analyze the protein profiles of MRSA strains ST398 and…
View article: Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli
Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli Open
Background Innovative antibiotic discovery strategies are urgently needed to successfully combat infections caused by multi-drug-resistant bacteria. Methods We employed a direct screening approach to identify compounds with antimicrobial …
View article: Author Correction: Metaproteomic portrait of the healthy human gut microbiota
Author Correction: Metaproteomic portrait of the healthy human gut microbiota Open
View article: Correction: Synergistic drug combinations designed to fully suppress SARS-CoV-2 in the lung of COVID-19 patients
Correction: Synergistic drug combinations designed to fully suppress SARS-CoV-2 in the lung of COVID-19 patients Open
[This corrects the article DOI: 10.1371/journal.pone.0276751.].
View article: Metaproteomic portrait of the healthy human gut microbiota
Metaproteomic portrait of the healthy human gut microbiota Open
View article: The metabolic footprint of Vero E6 cells highlights the key metabolic routes associated with SARS-CoV-2 infection and response to drug combinations
The metabolic footprint of Vero E6 cells highlights the key metabolic routes associated with SARS-CoV-2 infection and response to drug combinations Open
SARS-CoV-2 burdens healthcare systems worldwide, yet specific drug-based treatments are still unavailable. Understanding the effects of SARS-CoV-2 on host molecular pathways is critical for providing full descriptions and optimizing therap…
View article: Assessment of Lactococcus cremoris preparations for the pre- and post-milking teat disinfection
Assessment of Lactococcus cremoris preparations for the pre- and post-milking teat disinfection Open
Good hygienic milking practices include the disinfection of the cows’ teat skin before and after milking aimed at reducing the entry of pathogens and preventing the occurrence of new intramammary infections (IMI) in dairy cows. This practi…
View article: Comprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes
Comprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes Open
Omega-3 polyunsaturated fatty acids (n-3 PUFA), such as the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are reported to beneficially affect the intestinal immunity. The biological pathways modulated by n-3 PUFA during an in…
View article: Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increases fillet lipid quality in gilthead sea bream (Sparus aurata)
Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increases fillet lipid quality in gilthead sea bream (Sparus aurata) Open
View article: Data From Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increased fillet lipid quality in gilthead sea bream (Sparus aurata)
Data From Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increased fillet lipid quality in gilthead sea bream (Sparus aurata) Open
In the present study, gilthead sea breams (Sparus aurata) were reared using sustainable feeds containing insect meal from Hermetia illucens larvae. Proteomics and proton nuclear magnetic resonance-based metabolomics analy…
View article: Data from: Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increased fillet lipid quality in gilthead sea bream (Sparus aurata) juveniles
Data from: Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increased fillet lipid quality in gilthead sea bream (Sparus aurata) juveniles Open
In the present study, gilthead sea bream (Sparus aurata) juveniles were reared using sustainable feeds containing insect meal from Hermetia illucens larvae and poultry by-products meal. Proteomics and Proton Nuclear Magne…
View article: Data from: Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increased fillet lipid quality in gilthead sea bream (Sparus aurata) juveniles
Data from: Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increased fillet lipid quality in gilthead sea bream (Sparus aurata) juveniles Open
In the present study, gilthead sea bream (Sparus aurata) juveniles were reared using sustainable feeds containing insect meal from Hermetia illucens larvae and poultry by-products meal. Proteomics and Proton Nuclear Magne…
View article: Data from: Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increased fillet lipid quality in gilthead sea bream (Sparus aurata) juveniles
Data from: Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increased fillet lipid quality in gilthead sea bream (Sparus aurata) juveniles Open
In the present study, gilthead sea bream (Sparus aurata) juveniles were reared using sustainable feeds containing insect meal from Hermetia illucens larvae and poultry by-products meal. Proteomics and Proton Nuclear Magne…
View article: On the Compatibility of Fish Meal Replacements in Aquafeeds for Rainbow Trout. A Combined Metabolomic, Proteomic and Histological Study
On the Compatibility of Fish Meal Replacements in Aquafeeds for Rainbow Trout. A Combined Metabolomic, Proteomic and Histological Study Open
The sustainable development of modern aquaculture must rely on a significant reduction of the fish meal (FM) used in aquafeed formulations. However, FM substitution with alternative ingredients in diets for carnivorous fish species often s…
View article: Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches
Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches Open
The most used approaches in structure-based drug design possess peculiar characteristics with advantages and limitations, and thus the management of complementary data from various techniques is of particular interest to synergistically ac…
View article: Comparative secretome analysis of <i>Staphylococcus aureus</i> strains with different within-herd intramammary infection prevalence
Comparative secretome analysis of <i>Staphylococcus aureus</i> strains with different within-herd intramammary infection prevalence Open
Staphylococcus aureus is a major pathogen causing intramammary infection and mastitis in dairy cows. S. aureus genotypes (GT) can differ significantly in their ability to diffuse and persist in the herd; while the association…
View article: Exploring the DPP-IV Inhibitory, Antioxidant and Antibacterial Potential of Ovine “Scotta” Hydrolysates
Exploring the DPP-IV Inhibitory, Antioxidant and Antibacterial Potential of Ovine “Scotta” Hydrolysates Open
The aim of this work was to valorize the by-product derived from the ricotta cheese process (scotta). In this study, ovine scotta was concentrated by ultrafiltration and then subjected to enzymatic hydrolyses using proteases of both vegeta…
View article: Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota
Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota Open
View article: Comparative Evaluation of MaxQuant and Proteome Discoverer MS1-Based Protein Quantification Tools
Comparative Evaluation of MaxQuant and Proteome Discoverer MS1-Based Protein Quantification Tools Open
MS1-based label-free quantification can compare precursor ion peaks across runs, allowing reproducible protein measurements. Among bioinformatic platforms enabling MS1-based quantification, MaxQuant (MQ) is one of the most used, while Prot…
View article: Identification of conserved Mycoplasma agalactiae surface antigens by immunoproteomics
Identification of conserved Mycoplasma agalactiae surface antigens by immunoproteomics Open
View article: Proteomic datasets of uninfected and Staphylococcus aureus-infected goat milk
Proteomic datasets of uninfected and Staphylococcus aureus-infected goat milk Open
We present a proteomic dataset generated from half-udder Alpine goat milk. The milk samples belonged to 3 groups: i) mid-lactation, low somatic cell count, uninfected milk (MLU, n=3); ii) late lactation, high somatic cell count, uninfected…
View article: Impact of Staphylococcus aureus infection on the late lactation goat milk proteome: New perspectives for monitoring and understanding mastitis in dairy goats
Impact of Staphylococcus aureus infection on the late lactation goat milk proteome: New perspectives for monitoring and understanding mastitis in dairy goats Open
View article: Proteomic changes in the milk of water buffaloes (Bubalus bubalis) with subclinical mastitis due to intramammary infection by Staphylococcus aureus and by non-aureus staphylococci
Proteomic changes in the milk of water buffaloes (Bubalus bubalis) with subclinical mastitis due to intramammary infection by Staphylococcus aureus and by non-aureus staphylococci Open
View article: Liver proteome dataset of Sparus aurata exposed to low temperatures
Liver proteome dataset of Sparus aurata exposed to low temperatures Open
View article: Fecal Metaproteomic Analysis Reveals Unique Changes of the Gut Microbiome Functions After Consumption of Sourdough Carasau Bread
Fecal Metaproteomic Analysis Reveals Unique Changes of the Gut Microbiome Functions After Consumption of Sourdough Carasau Bread Open
Sourdough-leavened bread (SB) is acknowledged for its great variety of valuable effects on consumer's metabolism and health, including a low glycemic index and a reduced content of the possible carcinogen acrylamide. Here, we aimed to inve…
View article: Liver proteomics of gilthead sea bream (Sparus aurata) exposed to cold stress
Liver proteomics of gilthead sea bream (Sparus aurata) exposed to cold stress Open
View article: Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis
Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis Open
View article: Caloric restriction promotes functional changes involving short-chain fatty acid biosynthesis in the rat gut microbiota
Caloric restriction promotes functional changes involving short-chain fatty acid biosynthesis in the rat gut microbiota Open
Caloric restriction (CR) is known to promote health and longevity, likely via modification of the gut microbiota (GM). However, functional and metabolic changes induced in the GM during CR are still unidentified. Here, we investigated the …