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View article: Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy
Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy Open
Spinal muscular atrophy (SMA) is a genetic disorder characterized by the loss of spinal motor neurons. The conventional therapy does not always lead to a full restoration of the clinical symptoms, partially due to the need for early treatm…
View article: Food Insecurity is Associated with Obstructive Respiratory Disorders Among U.S. Adults: A Cross-Sectional Study
Food Insecurity is Associated with Obstructive Respiratory Disorders Among U.S. Adults: A Cross-Sectional Study Open
Introduction: Physical activity is associated with reduced risk for several chronic diseases; however, its association with cancer remains unclear, with mixed findings across literature. This study investigates the relationship between exe…
View article: Hericium erinaceus extracts promote neuronal differentiation and excitability through nootropic metabolite activity
Hericium erinaceus extracts promote neuronal differentiation and excitability through nootropic metabolite activity Open
This study investigates the effects of a blend of Hericium erinaceus (lion's mane mushroom) extract on the differentiation of SH-SY5Y cells, a human neuroblastoma cell line, revealing potential therapeutic implications for neuroblastoma ma…
View article: Impact of Fast-Mimicking Diet and Fasting Dietary Interventions on Cancer Outcomes in Adult Patients: A Scoping Review of Clinical Evidence
Impact of Fast-Mimicking Diet and Fasting Dietary Interventions on Cancer Outcomes in Adult Patients: A Scoping Review of Clinical Evidence Open
BACKGROUND Cancer represents a substantial burden in terms of morbidity and mortality on a global scale. Conventional cancer therapies tend to present adverse effects that significantly impair patients' quality of life. Recently, there has…
View article: A pathophysiological intersection between metabolic biomarkers and memory: a longitudinal study in the STZ-induced diabetic mouse model
A pathophysiological intersection between metabolic biomarkers and memory: a longitudinal study in the STZ-induced diabetic mouse model Open
Diabetes mellitus (DM) is a metabolic disorder characterized by high blood sugar levels due to insufficient insulin production or insulin resistance. Recently, metabolic biomarkers, such as glycated albumin (GA) and methylglyoxal (MGO), ha…
View article: Bio-Recycling Hazelnut Shells to Improve Antioxidant Properties of Lentinus tigrinus Sporophore
Bio-Recycling Hazelnut Shells to Improve Antioxidant Properties of Lentinus tigrinus Sporophore Open
Lentinus tigrinus is a wood-decay fungus known for its nutritional, culinary, and medicinal benefits. It contains bioactive compounds like polyphenols, terpenes, and flavonoids that exhibit antioxidant, anti-microbial, and anti-inflammator…
View article: Predation cues induce predator specific changes in olfactory neurons encoding defensive responses in agile frog tadpoles
Predation cues induce predator specific changes in olfactory neurons encoding defensive responses in agile frog tadpoles Open
Although behavioural defensive responses have been recorded several times in both laboratory and natural habitats, their neural mechanisms have seldom been investigated. To explore how chemical, water-borne cues are conveyed to the forebra…
View article: Hericium erinaceus Extract Exerts Beneficial Effects on Gut–Neuroinflammaging–Cognitive Axis in Elderly Mice
Hericium erinaceus Extract Exerts Beneficial Effects on Gut–Neuroinflammaging–Cognitive Axis in Elderly Mice Open
Ageing is a biological phenomenon that determines the impairment of cognitive performances, in particular, affecting memory. Inflammation and cellular senescence are known to be involved in the pathogenesis of cognitive decline. The gut mi…
View article: The Designer Drug αPHP Affected Cell Proliferation and Triggered Deathly Mechanisms in Murine Neural Stem/Progenitor Cells
The Designer Drug αPHP Affected Cell Proliferation and Triggered Deathly Mechanisms in Murine Neural Stem/Progenitor Cells Open
Increasing reports of neurological and psychiatric outcomes due to psychostimulant synthetic cathinones (SCs) have recently raised public concern. However, the understanding of neurotoxic mechanisms is still lacking, particularly for the u…
View article: Role of Na+/Ca2+ Exchanger (NCX) in Glioblastoma Cell Migration (In Vitro)
Role of Na+/Ca2+ Exchanger (NCX) in Glioblastoma Cell Migration (In Vitro) Open
Glioblastoma (GBM) is the most malignant form of primary brain tumor. It is characterized by the presence of highly invasive cancer cells infiltrating the brain by hijacking neuronal mechanisms and interacting with non-neuronal cell types,…
View article: Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?
Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? Open
A growing number of studies is focusing on the pharmacology and feasibility of bioactive compounds as a novel valuable approach to target a variety of human diseases related to neurological degeneration. Among the group of the so-called me…
View article: Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract
Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract Open
Brain aging is a crucial risk factor for several neurodegenerative disorders and dementia. The most affected cognitive function is memory, worsening early during aging. Inflammation and oxidative stress are known to have a role in pathogen…
View article: Fighting secondary triple-negative breast cancer in cerebellum: A powerful aid from a medicinal mushrooms blend
Fighting secondary triple-negative breast cancer in cerebellum: A powerful aid from a medicinal mushrooms blend Open
Breast cancer (BC) is the second most common cause of brain metastasis onset in patients, with the cerebellum accounting for the 33% of cases. In the current study, using a 4T1 triple-negative mouse BC model, we revealed that an orally adm…
View article: The Many Ages of Microbiome–Gut–Brain Axis
The Many Ages of Microbiome–Gut–Brain Axis Open
Frailty during aging is an increasing problem associated with locomotor and cognitive decline, implicated in poor quality of life and adverse health consequences. Considering the microbiome–gut–brain axis, we investigated, in a longitudina…
View article: Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging
Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging Open
Phenotypic frailty is characterized by a progressive decline in physical functioning. During ageing, morphological and functional alterations involve the brain, and chief theories involve oxidative stress, free radical accumulation, and re…
View article: Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging
Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging Open
Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e., inflammaging. In the current study, we investigated the effect of a two-month oral supplementati…
View article: Deeper and Deeper on the Role of BK and Kir4.1 Channels in Glioblastoma Invasiveness: A Novel Summative Mechanism?
Deeper and Deeper on the Role of BK and Kir4.1 Channels in Glioblastoma Invasiveness: A Novel Summative Mechanism? Open
In the last decades, increasing evidence has revealed that a large number of channel protein and ion pumps exhibit impaired expression in cancers. This dysregulation is responsible for high proliferative rates as well as migration and inva…
View article: From a Medicinal Mushroom Blend a Direct Anticancer Effect on Triple-Negative Breast Cancer: A Preclinical Study on Lung Metastases
From a Medicinal Mushroom Blend a Direct Anticancer Effect on Triple-Negative Breast Cancer: A Preclinical Study on Lung Metastases Open
Bioactive metabolites isolated from medicinal mushrooms (MM) used as supportive treatment in conventional oncology have recently gained interest. Acting as anticancer agents, they interfere with tumor cells and microenvironment (TME), dist…
View article: Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model
Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model Open
Although medicinal mushroom extracts have been proposed as promising anti-cancer agents, their precise impacts on metastatic breast cancer are still to be clarified. For this purpose, the present study exploited the effect of a novel medic…
View article: Squaring the Circle: A New Study of Inward and Outward-Rectifying Potassium Currents in U251 GBM Cells
Squaring the Circle: A New Study of Inward and Outward-Rectifying Potassium Currents in U251 GBM Cells Open
View article: Array of Metabolites in Italian Hericium erinaceus Mycelium, Primordium, and Sporophore
Array of Metabolites in Italian Hericium erinaceus Mycelium, Primordium, and Sporophore Open
Hericium erinaceus is a medicinal mushroom that contains many molecules promising a plethora of therapeutic properties. In this study, the strain H.e.2 (MicUNIPV, University of Pavia, Italy) was isolated from a sporophore collected in Tusc…
View article: Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment. Open
Dental care units are often the front line for a clinical evaluation of a possible HPV lesion in the oral cavity, which means that correct clinical governance could avoid a viral neoplastic progression of this disease with great advantages…
View article: <i>Hericium erinaceus</i> Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?
<i>Hericium erinaceus</i> Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Open
Epidemiological data indicate that subjects affected by obesity have an increased risk of developing mood disorders. The relationship between obesity and mood disorders is bidirectional. We assessed whether a Hericium erinaceus treatment i…
View article: Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging
Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging Open
Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associate…
View article: The Gut-Brain Axis in Alzheimer’s Disease and Omega-3. A Critical Overview of Clinical Trials
The Gut-Brain Axis in Alzheimer’s Disease and Omega-3. A Critical Overview of Clinical Trials Open
Despite intensive study, neurodegenerative diseases remain insufficiently understood, precluding rational design of therapeutic interventions that can reverse or even arrest the progressive loss of neurological function. In the last decade…
View article: LncRNA colon cancer-associated transcript 1 (CCAT1) in ovarian cancer.
LncRNA colon cancer-associated transcript 1 (CCAT1) in ovarian cancer. Open
We read the study published by Lai et al1 with great interest. The complex nature of neoplastic
\ntransformation has an enormous impact at various moments of the cancer diagnostics and therapy
\nprotocols. Sophisticated individualized ther…