Explanipedia

Disparities in Cardiovascular Disease in Women with Adverse Pregnancy Outcomes Open

Maria Rivera, Santiago Clocchiatti‐Tuozzo, Daniela Renedo, Cyprien Rivier, Shufan Huo , et al. · 2025

Background Although adverse pregnancy outcomes (APOs) have been linked to increased cardiovascular disease (CVD) risk, most studies have focused on homogenous populations. We tested the hypothesis that APOs and race and ethnicity synergist…

Clot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review Open

Jacob Kosyakovsky, Christina P. Rossitto, Joseph Antonios, Daniela Renedo, Christopher J. Stapleton , et al. · 2025

Acute ischemic stroke (AIS) is one of the leading global causes of mortality and morbidity. Clearer understanding of stroke etiology is a major clinical objective to determine appropriate strategies for secondary stroke prevention. Histolo…

Characterizing Stroke Clots Using Single‐Cell Sequencing Open

Daniela Renedo, Tanyeri Barak, Jonathan H. DeLong, Julián Acosta, Nanthiya Sujijantarat , et al. · 2025

Background Ischemic stroke results in significant morbidity and mortality. By examining gene expression of cells comprising stroke clots, we aim to gain valuable insights into the underlying mechanisms of this disease and identify potentia…

Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series: Corrigendum Open

Nanthiya Sujijantarat, Andrew B. Koo, Aladine A. Elsamadicy, Joseph Antonios, Daniela Renedo , et al. · 2025

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Impact of Social Determinants of Health on Outcomes of Nontraumatic Subarachnoid Hemorrhage Open

Daniela Renedo, Cyprien Rivier, Andrew B. Koo, Santiago Clocchiatti‐Tuozzo, Shufan Huo , et al. · 2025

Background Nontraumatic subarachnoid hemorrhage (SAH) presents a significant health burden, yet the influence of social determinants of health on outcomes remains unclear. This study examines the impact of social determinants of health on …

Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression Open

Cyprien Rivier, Natalia Szejko, Daniela Renedo, Santiago Clocchiatti‐Tuozzo, Shufan Huo , et al. · 2025

Chronological age is an imperfect estimate of molecular aging. Epigenetic age, derived from DNA methylation data, provides a more nuanced representation of aging-related biological processes. We examine the bidirectional relationship betwe…

Genal: a Python toolkit for genetic risk scoring and Mendelian randomization Open

Cyprien Rivier, Santiago Clocchiatti‐Tuozzo, Shufan Huo, Victor M Torres Lopez, Daniela Renedo , et al. · 2024

Motivation The expansion of genetic association data from genome-wide association studies has increased the importance of methodologies like Polygenic Risk Scores (PRS) and Mendelian Randomization (MR) in genetic epidemiology. However, the…

Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage Open

Cyprien Rivier, Daniela Renedo, Sandro Marini, Jessica Magid-Bernstein, Adam de Havenon , et al. · 2024

Objective The limited existing evidence on sex differences in the clinical characteristics of patients with spontaneous, non‐traumatic intracerebral hemorrhage (ICH) comes from small, single‐center studies. Here, we performed an individual…

Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series Open

Nanthiya Sujijantarat, Andrew B. Koo, Aladine A. Elsamadicy, Joseph Antonios, Daniela Renedo , et al. · 2024

BACKGROUND AND OBJECTIVES: Neurosurgical management of idiopathic intracranial hypertension (IIH) can be challenging given high rates of revision associated with cerebrospinal fluid shunting. In this study, we present a technical report an…

Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis Open

Nanthiya Sujijantarat, Kelsey A. Templeton, Joseph Antonios, Daniela Renedo, Andrew B. Koo , et al. · 2024

Background Prior studies have suggested an association between clot histological composition and cause of stroke. However, the results have been conflicting. Our objective is to provide an updated systematic review and meta‐analysis of the…

Bidirectional relationship between epigenetic age and brain health events Open

Cyprien Rivier, Natalia Szejko, Daniela Renedo, Santiago Clocchiatti‐Tuozzo, Shufan Huo , et al. · 2024

Chronological age offers an imperfect estimate of the molecular changes that occur with aging. Epigenetic age, which is derived from DNA methylation data, provides a more nuanced representation of aging-related biological processes. This s…

Genal: A Python Toolkit for Genetic Risk Scoring and Mendelian Randomization Open

Cyprien Rivier, Santiago Clocchiatti‐Tuozzo, Shufan Huo, Victor M Torres Lopez, Daniela Renedo , et al. · 2024

Summary Here we present Genal, a python module for population genetic analyses. It includes functionalities for cleaning and formatting Single Nucleotide Polymorphism (SNP)-level data, clumping, lifting, SNP association testing, polygenic …

Angiographic evidence of an inadvertent cannulation of the marginal sinus following central line migration: illustrative case Open

Abdelaziz Amllay, Edwin Owolo, Kamil W. Nowicki, Nanthiya Sujijantarat, Andrew B. Koo , et al. · 2024

BACKGROUND Central venous catheters (CVCs) play an indispensable role in clinical practice. Catheter malposition and tip migration can lead to severe complications. The authors present a case illustrating the endovascular management of ina…

Impact of Procedure Time on First Pass Effect in Mechanical Thrombectomy for Anterior Circulation Acute Ischemic Stroke Open

Andrew B. Koo, Benjamin C. Reeves, Daniela Renedo, Ilko Maier, Sami Al Kasab , et al. · 2024

BACKGROUND AND OBJECTIVES: First pass effect (FPE) is a metric increasingly used to determine the success of mechanical thrombectomy (MT) procedures. However, few studies have investigated whether the duration of the procedure can modify t…

Burden of Ischemic and Hemorrhagic Stroke Across the US From 1990 to 2019 Open

Daniela Renedo, Julián Acosta, Audrey C. Leasure, Richa Sharma, Harlan M. Krumholz , et al. · 2024

Importance Stroke is a leading cause of death and disability in the US. Accurate and updated measures of stroke burden are needed to guide public health policies. Objective To present burden estimates of ischemic and hemorrhagic stroke in …

<i>APOE</i> ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation Open

Daniela Renedo, Cyprien Rivier, Andrew B. Koo, Nanthiya Sujijantarat, Santiago Clocchiatti‐Tuozzo , et al. · 2024

Importance Intracerebral hemorrhage (ICH) is a serious complication of brain arteriovenous malformation (AVM). Apolipoprotein E ( APOE ) ε4 is a well-known genetic risk factor for ICH among persons without AVM, and cerebral amyloid angiopa…

COVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage Open

Daniela Renedo, Audrey C. Leasure, Rebecca Young, Cyprien Rivier, Brooke Alhanti , et al. · 2024

Background Patients with ischemic stroke and concomitant COVID‐19 infection have worse outcomes than those without this infection, but the impact of COVID‐19 on hemorrhagic stroke remains unclear. We aimed to assess if COVID‐19 worsens out…

Neighborhood Deprivation, Race, Ethnicity, and Undiagnosed Hypertension: Results From the All of Us Research Program Open

Cyprien Rivier, Daniela Renedo, N. Abimbola Sunmonu, Adam de Havenon, Kevin N. Sheth , et al. · 2024

Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia Open

Santiago Clocchiatti‐Tuozzo, Cyprien Rivier, Daniela Renedo, Victor M Torres Lopez, Jacqueline H. Geer , et al. · 2023

Background The American Heart Association's Life's Simple 7, a public health construct capturing key determinants of cardiovascular health, became the Life's Essential 8 after the addition of sleep duration. The authors tested the hypothes…

Association of Poor Oral Health With Neuroimaging Markers of White Matter Injury in Middle-Aged Participants in the UK Biobank Open

Cyprien Rivier, Daniela Renedo, Adam de Havenon, N. Abimbola Sunmonu, Thomas M. Gill , et al. · 2023

Among middle age Britons without stroke or dementia, poor oral health was associated with worse neuroimaging brain health profiles. Genetic analyses confirmed these associations, supporting a potentially causal association. Because the neu…

Polygenic Susceptibility to Diabetes and Poor Glycemic Control in Stroke Survivors Open

Zachariah S. Demarais, Carolyn Conlon, Shufan Huo, Cyprien Rivier, Daniela Renedo , et al. · 2023

Importance Type 2 diabetes mellitus is a highly heritable disease with numerous identified genetic risk variants. However, the concrete role of these variants in the clinical care of stroke patients remains poorly understood. Objective To …

Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury Open

Nanthiya Sujijantarat, Andrew B. Koo, Ivan Jambor, Ajay Malhotra, Mercy H. Mazurek , et al. · 2023

Background Timely imaging is essential for patients undergoing mechanical thrombectomy (MT). Our objective was to evaluate the safety and feasibility of low‐field portable magnetic resonance imaging (pMRI) for bedside evaluation following …

Polygenic Susceptibility to Hypertension and Cognitive Performance in Middle-aged Persons Without Stroke or Dementia Open

Cyprien Rivier, Natalia Szejko, Daniela Renedo, Rommell B. Noche, J. Acosta , et al. · 2023

Among nondemented, community-dwelling, middle-aged Britons, a higher PSH is associated with worse cognitive performance. These findings suggest that genetic predisposition to hypertension influences brain health in persons who have not yet…

Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses Open

Daniela Renedo, Julián Acosta, Andrew B. Koo, Cyprien Rivier, Nanthiya Sujijantarat , et al. · 2023

Background: Frailty is a prevalent state associated with several aging-related traits and conditions. The relationship between frailty and stroke remains understudied. Here we aim to investigate whether the hospital frailty risk score (HFR…

COVID-19 Infection Is Associated with Poor Outcomes in Patients with Intracerebral Hemorrhage Open

Daniela Renedo, Audrey C. Leasure, Rebecca Young, Cyprien Rivier, Brooke Alhanti , et al. · 2023

Background Patients with ischemic stroke and concomitant coronavirus 2019 (COVID-19) infection have worse outcomes than those without this infection. However, research on the impact of COVID-19 infection on outcomes following hemorrhagic s…

Suboptimal Sleep Duration is Associated with Poorer Neuroimaging Brain Health Profiles Open

Santiago Clocchiatti‐Tuozzo, Cyprien Rivier, Daniela Renedo, Victor M Torres Lopez, Jacqueline H. Geer , et al. · 2023

Background Cardiovascular health optimization during middle age benefits brain health. The American Heart Association’s Life’s Simple 7 recently added sleep duration as a key determinant of cardiovascular health becoming the Life’s Essenti…

Poor Oral Health Is Associated with Worse Brain Imaging Profiles Open

Cyprien Rivier, Daniela Renedo, Adam de Havenon, Thomas M. Gill, Seyedmehdi Payabvash , et al. · 2023

Importance Poor oral health is a modifiable risk factor that is associated with a variety of health outcomes. However, the relationship between oral and brain health is not well understood. Objective To test the hypothesis that poor oral h…

Burden of Ischemic and Hemorrhagic Stroke Across the US from 1990-2019: A Global Burden of Disease Study Open

Daniela Renedo, Julián Acosta, Audrey C. Leasure, Richa Sharma, Harlan M. Krumholz , et al. · 2023

WITHDRAWN: Risk Factors Related to Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Retrospective Cohort Study Open

Marcos Ezequiel Yasuda, Daniela Renedo, Soledad Sosa, Karina Danilowicz, Rodolfo Recalde , et al. · 2022

Objective : To analyze and find risk factors associated with the development of DI using a multicenter case series via TSE. Materials and methods: Medical records of patients who underwent TSS for PA resection between 2010-2021 at three di…

Polygenic Susceptibility to Hypertension is Associated with Worse Cognitive Performance in Middle-Aged Persons without Dementia Open

Cyprien Rivier, Natalia Szejko, Daniela Renedo, Rommell Noche, Julián Acosta , et al. · 2022

Background Mounting evidence indicates that hypertension leads to higher risk of cognitive decline and dementia. Hypertension is a highly heritable trait and a higher polygenic susceptibility to hypertension (PSH) is known to be associated…

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