Daniela Röll
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View article: A randomized trial of simultaneous versus sequential pneumococcal vaccination in elderly
A randomized trial of simultaneous versus sequential pneumococcal vaccination in elderly Open
Simultaneous vaccination did not elicit higher memory B cell responses compared to sequential or single vaccination. All approaches were safe.
View article: Staphylococcus aureus biofilm-associated component PNAG stimulates the secretion of the immunomodulatory chemokine CXCL10 via Dectin-1 signaling
Staphylococcus aureus biofilm-associated component PNAG stimulates the secretion of the immunomodulatory chemokine CXCL10 via Dectin-1 signaling Open
Staphylococcus aureus is a common human pathogen associated with many infections. The key factor contributing to the virulence of S. aureus is its ability to form difficult-to-treat and recalcitrant biofilms. One of the major staphylococca…
View article: Exploring secretory proteome and cytokine kinetic of human peripheral blood mononuclear cells exposed to methicillin-resistant Staphylococcus aureus biofilms and planktonic bacteria
Exploring secretory proteome and cytokine kinetic of human peripheral blood mononuclear cells exposed to methicillin-resistant Staphylococcus aureus biofilms and planktonic bacteria Open
Staphylococcus aureus is a highly successful pathogen infecting various body parts and forming biofilms on natural and artificial surfaces resulting in difficult-to-treat and chronic infections. We investigated the secreted cytokines and p…
View article: PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power
PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power Open
The current risk stratification in prostate cancer (PCa) is frequently insufficient to adequately predict disease development and outcome. One hallmark of cancer is telomere maintenance. For telomere maintenance, PCa cells exclusively empl…
View article: Reprogramming of macrophages employing gene regulatory and metabolic network models
Reprogramming of macrophages employing gene regulatory and metabolic network models Open
Upon exposure to different stimuli, resting macrophages undergo classical or alternative polarization into distinct phenotypes that can cause fatal dysfunction in a large range of diseases, such as systemic infection leading to sepsis or t…
View article: Use of IFNγ/IL10 ratio for stratification of hydrocortisone therapy in patients with septic shock
Use of IFNγ/IL10 ratio for stratification of hydrocortisone therapy in patients with septic shock Open
Background Large clinical trials testing hydrocortisone therapy in septic shock have produced conflicting results. Subgroups may however benefit depending on their individual immune response. Methods We performed an exploratory analysis of…
View article: Androgen-regulation of sepsis response : beneficial role of androgen receptor antagonists
Androgen-regulation of sepsis response : beneficial role of androgen receptor antagonists Open
Sepsis ist definiert als Wirtsreaktion auf eine systemische Infektion und zählt weltweit zu den führenden Gründen von Morbidität und Mortalität. Therapeutische Strategien beschränken sich auf rasche und adäquate antibiotische Intervention …