Daniela Gompelmann
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View article: Primary pulmonary chondrosarcoma: clinical case and review of the literature
Primary pulmonary chondrosarcoma: clinical case and review of the literature Open
Mesenchymal chondrosarcoma is a malignant tumor that arises from cartilage-forming cells and typically affects the bones, but in rare cases also the lungs. Due to its rarity, there is limited knowledge about the clinical presentation, diag…
View article: Transbronchial Cryobiopsy under Simultaneous Confocal Laser Endomicroscopy Guidance for Peripheral Pulmonary Lesions: A Pilot Study
Transbronchial Cryobiopsy under Simultaneous Confocal Laser Endomicroscopy Guidance for Peripheral Pulmonary Lesions: A Pilot Study Open
Introduction: Radial endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) is the most used technique for the diagnosis of peripheral pulmonary lesions. However, the TBB cannot be performed under simultaneous ultrasound guida…
View article: Management and Outcomes of Pulmonary Nodules in a Real-World Setting
Management and Outcomes of Pulmonary Nodules in a Real-World Setting Open
Background and Objective: Due to the increasing use of imaging and lung cancer screening programs, the rate of detected pulmonary nodules has steadily increased over the past decade. Overall, the diagnosis and management of pulmonary nodul…
View article: Development and validation of two bronchoscopy knowledge assessments
Development and validation of two bronchoscopy knowledge assessments Open
Introduction: Simulation-based training (SBT) is a key method for teaching bronchoscopy skills to pulmonology residents. A theoretical foundation can enhance SBT efficiency. This study developed and evaluated the validity of an anatomy and…
View article: Immunophenotyping of bronchoalveolar lavage and functional impairment in post-COVID syndrome
Immunophenotyping of bronchoalveolar lavage and functional impairment in post-COVID syndrome Open
Summary Objective Following recovery from COVID-19, there is evidence for pulmonary sequelae and functional impairment. Data regarding the immunopathological mechanisms are limited. This study aimed to investigate the relationship between …
View article: The Mesothelioma Systemic Inflammation Score Is Independently Associated with Overall Survival and Predicts Benefit of Multimodality Treatment in Pleural Mesothelioma
The Mesothelioma Systemic Inflammation Score Is Independently Associated with Overall Survival and Predicts Benefit of Multimodality Treatment in Pleural Mesothelioma Open
Background/Objectives: Malignant pleural mesothelioma (MPM) remains challenging to treat, with a poor prognosis. As controversy about clinical management continues, predictive biomarkers for patient selection to indicate the benefit of tre…
View article: First insights and future research perspectives from the sarcoidosis registry at the Medical University of Vienna
First insights and future research perspectives from the sarcoidosis registry at the Medical University of Vienna Open
Sarcoidosis is a systemic granulomatous disease that may differ in clinical presentation, organ involvement and severity among different populations. The primary objective was to evaluate demographic characteristics, disease stage, diagnos…
View article: AI-powered evaluation of lung function for diagnosis of interstitial lung disease
AI-powered evaluation of lung function for diagnosis of interstitial lung disease Open
Background The diagnosis of interstitial lung disease (ILD) can pose a challenge as the pulmonary function test (PFT) is only minimally affected at the onset. To improve early diagnosis, this study aims to explore the potential of artifici…
View article: Impact of Neoadjuvant and Adjuvant Pleural Intensity‐Modulated Radiotherapy in Multimodality Treatment for Malignant Pleural Mesothelioma
Impact of Neoadjuvant and Adjuvant Pleural Intensity‐Modulated Radiotherapy in Multimodality Treatment for Malignant Pleural Mesothelioma Open
Background Few malignancies provoke as many controversies about treatment as pleural mesothelioma. There is limited experience with novel radiotherapy techniques worldwide in adjuvant and particularly in neoadjuvant settings within multimo…
View article: Determination and Comparison of the Pathogen Spectrum Evaluated by Microbial Culture and Multiplex PCR During Bronchoscopy with Regard to Clinical Utility of Routine Bronchial Wash in Patients with Various Pulmonary Diseases
Determination and Comparison of the Pathogen Spectrum Evaluated by Microbial Culture and Multiplex PCR During Bronchoscopy with Regard to Clinical Utility of Routine Bronchial Wash in Patients with Various Pulmonary Diseases Open
Background/Objectives: Bronchial wash for microbiological cultivation and/or multiplex polymerase chain reaction (PCR) is often routinely performed during bronchoscopy independent of the indication for bronchoscopy. This study aimed to det…
View article: Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s
Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s Open
Female Caucasian patients seem to have a higher susceptibility to lung cancer. Although the rate of genetic alterations is similar in both sexes, actionable driver mutations are significantly more common in women.
View article: Low-Dose Whole-Chest Dynamic CT for the Assessment of Large Airway Collapsibility in Patients with Suspected Tracheobronchial Instability
Low-Dose Whole-Chest Dynamic CT for the Assessment of Large Airway Collapsibility in Patients with Suspected Tracheobronchial Instability Open
Low-dose four-dimensional CT was feasible for diagnosis, localization, phenotyping, and computational quantification of dynamic collapsibility of the trachea during shallow breathing; concordance with bronchoscopy was moderate and with pai…
View article: Bronchoscopy with and without needle-based confocal laser endomicroscopy for peripheral lung nodule diagnosis: protocol for a multicentre randomised controlled trial (CLEVER trial)
Bronchoscopy with and without needle-based confocal laser endomicroscopy for peripheral lung nodule diagnosis: protocol for a multicentre randomised controlled trial (CLEVER trial) Open
Introduction Despite many technological advances, the diagnostic yield of bronchoscopic peripheral lung nodule analysis remains limited due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) enables real-time mic…
View article: Twenty four-month follow-up after bullectomy, unilateral and bilateral lung volume reduction surgery: a single-center retrospective analysis of consecutive cases
Twenty four-month follow-up after bullectomy, unilateral and bilateral lung volume reduction surgery: a single-center retrospective analysis of consecutive cases Open
Purpose While pharmacologic therapy remains the cornerstone of lung emphysema treatment, surgery is an additional therapeutic option in selected patient groups with advanced emphysema. The aim of lung volume reduction surgery (LVRS) is to …
View article: Smoking-Associated Endotracheal Hair Growth: A Case Report on Tracheal Complications
Smoking-Associated Endotracheal Hair Growth: A Case Report on Tracheal Complications Open
BACKGROUND A 52-year-old male patient presented with symptoms of chronic cough and persistent tracheal irritation 26 years after surgical closure of a tracheostoma, supported by an autologous auricular cartilage graft and cutaneous transpl…
View article: Low-dose and standard-dose whole-body [18F]FDG-PET/CT imaging: implications for healthy controls and lung cancer patients
Low-dose and standard-dose whole-body [18F]FDG-PET/CT imaging: implications for healthy controls and lung cancer patients Open
Aim: High-sensitivity hybrid positron emission tomography (PET) imaging using advanced whole-body (WB) or total-body PET/computed tomography (CT) systems permits reducing injected tracer activity while preserving diagnostic quality. Such a…
View article: Evaluation of PD-1 and interleukin-10-receptor expression by T lymphocytes in malignant and benign pleural effusions
Evaluation of PD-1 and interleukin-10-receptor expression by T lymphocytes in malignant and benign pleural effusions Open
Background: PD-1 (programmed cell death protein-1)/PD-L1 (programmed cell death ligand-1) as well as IL-10 (interleukin-10)/IL-10R (interleukin-10 receptor) interactions play a major role in tumor immune evasion in various malignancies. Se…
View article: Pharmacokinetics of isavuconazole at different target sites in healthy volunteers after single and multiple intravenous infusions
Pharmacokinetics of isavuconazole at different target sites in healthy volunteers after single and multiple intravenous infusions Open
Background Invasive aspergillosis is a severe fungal infection that affects multiple organ systems including the CNS and the lungs. Isavuconazole, a novel triazole antifungal agent, has demonstrated promising activity against Aspergillus s…
View article: Deep immune profiling of chronic rhinosinusitis in allergic and non-allergic cohorts using mass cytometry
Deep immune profiling of chronic rhinosinusitis in allergic and non-allergic cohorts using mass cytometry Open
Chronic rhinosinusitis (CRS) is a persistent nasal and paranasal sinus mucosa inflammation comprising two phenotypes, namely CRS with nasal polyps (CRSwNP) and without (CRSsNP). CRSwNP can be associated with asthma and hypersensitivity to …
View article: Deep immune profiling of chronic rhinosinusitis in allergic and non-allergic cohorts using mass cytometry
Deep immune profiling of chronic rhinosinusitis in allergic and non-allergic cohorts using mass cytometry Open
Background Chronic rhinosinusitis (CRS) is characterized by persistent nasal and paranasal sinus mucosa inflammation. It comprises two phenotypes, namely CRS with nasal polyps (CRSwNP) and without (CRSsNP). CRSwNP can be associated with as…
View article: PD-L1 assessment in lung cancer biopsies—pitfalls and limitations
PD-L1 assessment in lung cancer biopsies—pitfalls and limitations Open
The programmed cell death-ligand 1 (PD-L1) protein expression on tumor cells predicts the efficacy of immunotherapy in patients with non-small cell lung cancer. However, the assessment of PD-L1 expression on tumor cells has limited power f…
View article: Ventilatory support and inflammatory peptides in hospitalised patients with COVID-19: A prospective cohort trial
Ventilatory support and inflammatory peptides in hospitalised patients with COVID-19: A prospective cohort trial Open
Purpose Several studies have shown that SARS-CoV-2 can induce a massive release of cytokines which contributes to disease severity and mortality. Therefore, cytokine levels in the serum may help to predict disease severity and survival in …
View article: Sustained Treatment Response after Intravenous Cyclophosphamide in a Patient with Therapy-Resistant COVID-19 Acute Respiratory Distress Syndrome: A Case Report
Sustained Treatment Response after Intravenous Cyclophosphamide in a Patient with Therapy-Resistant COVID-19 Acute Respiratory Distress Syndrome: A Case Report Open
Treatment of acute respiratory distress syndrome (ARDS) represents a severe complication of coronavirus disease 2019 (COVID-19) infection and is often challenging in intensive care treatment. Potential positive effects of intravenous cyclo…
View article: Evaluation of PD-1 T lymphocytes in bronchoalveolar lavage in lung cancer compared to benign lung diseases
Evaluation of PD-1 T lymphocytes in bronchoalveolar lavage in lung cancer compared to benign lung diseases Open
The expression of the programmed cell death protein 1 (PD-1) has been shown to be markedly increased in tumor-infiltrating lymphocytes. However, the proportion of PD-1 + T cells in the bronchoalveolar lavage (BAL) of lung cancer patients h…
View article: Cardiovascular Diseases in COPD: From Diagnosis and Prevalence to Therapy
Cardiovascular Diseases in COPD: From Diagnosis and Prevalence to Therapy Open
Chronic obstructive pulmonary disease (COPD) is considered one of the leading causes of mortality. Cardiovascular comorbidities are diagnosed often in COPD patients, not only because of the common risk factors these two diseases share, but…
View article: Endobronchial Valve Replacements in Patients with Advanced Emphysema After Endoscopic Lung Volume Reduction
Endobronchial Valve Replacements in Patients with Advanced Emphysema After Endoscopic Lung Volume Reduction Open
Valve replacements are more likely to be beneficial in patients who develop a re-aeration of a previous lobar atelectasis following valve implantation. Every decision for revision bronchoscopy must be taken carefully.