Daniela S. Valdes
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View article: OpenDVP: An experimental and computational framework for community-empowered deep visual proteomics
OpenDVP: An experimental and computational framework for community-empowered deep visual proteomics Open
Deep visual proteomics (DVP) is an emerging approach for cell type-specific and spatially resolved proteomics. However, its broad adoption has been constrained by the lack of an open-source end-to-end workflow in a community-driven ecosyst…
View article: Maternal smoking in early pregnancy disrupts placental function through syncytiotrophoblast and macrophage dysregulation
Maternal smoking in early pregnancy disrupts placental function through syncytiotrophoblast and macrophage dysregulation Open
Summary Smoking in pregnancy is the leading avoidable cause of gestational morbidity and mortality, causally linked to fetal growth restriction (FGR). The placenta, functional interface between mother and fetus is essential for healthy fet…
View article: Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface
Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface Open
This study suggests that maternal platelet-derived factors affect the transcriptional profile of trophoblasts, including upregulation of LAIR2, which may be involved in fine-tuning the coagulation of maternal blood leaking from eroded deci…
View article: Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface
Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface Open
Aims The gastrointestinal (GI) tract is composed of distinct sub-regions, which exhibit segment-specific differences in microbial colonization and (patho)physiological characteristics. Gut microbes can be collectively considered as an acti…
View article: Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia
Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia Open
Pre-eclampsia (PE) is a syndrome that affects multiple organ systems and is the most severe hypertensive disorder in pregnancy. It frequently leads to preterm delivery, maternal and fetal morbidity and mortality, and life-long complication…
View article: Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia
Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia Open
Pre-eclampsia (PE) is a syndrome that affects multiple organ systems and is the most severe hypertensive disorder in pregnancy. It frequently leads to preterm delivery, maternal and fetal morbidity and mortality, and life-long complication…
View article: Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia
Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia Open
Pre-eclampsia (PE) is a syndrome that affects multiple organ systems and is the most severe hypertensive disorder in pregnancy. It frequently leads to preterm delivery, maternal and fetal morbidity and mortality, and life-long complication…
View article: Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia
Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia Open
Pre-eclampsia (PE) is a syndrome that affects multiple organ systems and is the most severe hypertensive disorder in pregnancy. It frequently leads to preterm delivery, maternal and fetal morbidity and mortality, and life-long complication…
View article: Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia
Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia Open
Pre-eclampsia (PE) is a syndrome that affects multiple organ systems and is the most severe hypertensive disorder in pregnancy. It frequently leads to preterm delivery, maternal and fetal morbidity and mortality, and life-long complication…
View article: Senescent Syncytiotrophoblast Secretion During Early Onset Preeclampsia
Senescent Syncytiotrophoblast Secretion During Early Onset Preeclampsia Open
BACKGROUND: Preeclampsia is a severe hypertensive disorder in pregnancy that causes preterm delivery, maternal and fetal morbidity, mortality, and life-long sequelae. Understanding the pathogenesis of preeclampsia is a critical first step …
View article: Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface
Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface Open
Aims The gastrointestinal (GI) tract is composed of distinct subregions which exhibit segment-specific differences in microbial colonization and (patho)physiological characteristics. Gut microbes can be collectively considered as an active…
View article: CD39 abrogates platelet-derived factors induced IL-1β expression in the human placenta
CD39 abrogates platelet-derived factors induced IL-1β expression in the human placenta Open
Tissue insults in response to inflammation, hypoxia and ischemia are accompanied by the release of ATP into the extracellular space. There, ATP modulates several pathological processes, including chemotaxis, inflammasome induction and plat…
View article: Ten simple rules for implementing open and reproducible research practices after attending a training course
Ten simple rules for implementing open and reproducible research practices after attending a training course Open
Open, reproducible, and replicable research practices are a fundamental part of science. Training is often organized on a grassroots level, offered by early career researchers, for early career researchers. Buffet style courses that cover …
View article: Disturbed trophoblast transition links preeclampsia progression from placenta to the maternal syndrome
Disturbed trophoblast transition links preeclampsia progression from placenta to the maternal syndrome Open
Summary Pre-eclampsia (PE) is a syndrome that affects multiple organ systems and is the most severe hypertensive disorder in pregnancy. It frequently leads to preterm delivery, maternal and fetal morbidity and mortality and life-long compl…
View article: Ten simple rules for implementing open and reproducible research practices after attending a training course
Ten simple rules for implementing open and reproducible research practices after attending a training course Open
Training in robust research practices is becoming increasingly common. However, many course participants may encounter challenges in implementation of what they learned after returning to their research groups. In this piece, we summarize …
View article: Impaired cell interactions at the pre-eclamptic maternal-foetal interface
Impaired cell interactions at the pre-eclamptic maternal-foetal interface Open
Hypertensive disorders in pregnancy, of which the multisystem pathology pre-eclampsia is most severe, often lead to preterm delivery, maternal mortality and life-long complications1. Pre-eclampsia lacks early screening tools
View article: Impaired cell interactions at the pre-eclamptic maternal-foetal interface
Impaired cell interactions at the pre-eclamptic maternal-foetal interface Open
<p>Hypertensive disorders in pregnancy, of which the multisystem pathology pre-eclampsia is most severe, often lead to preterm delivery, maternal mortality and life-long complications<sup>1</sup>. Pre-eclampsia lacks earl…
View article: Reprogramming roadmap reveals route to human induced trophoblast stem cells
Reprogramming roadmap reveals route to human induced trophoblast stem cells Open