Daniela Schillinger
YOU?
Author Swipe
View article: Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut
Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut Open
View article: Clinical Response to Vedolizumab in Ulcerative Colitis Patients Is Associated with Changes in Integrin Expression Profiles
Clinical Response to Vedolizumab in Ulcerative Colitis Patients Is Associated with Changes in Integrin Expression Profiles Open
Our data show that clinical response to vedolizumab therapy in UC but not in CD is associated with specific changes in integrin expression profiles opening novel avenues for mechanistic research and possibly prediction of response to thera…
View article: The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohnʼs Disease Effector T Cells In Vivo
The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohnʼs Disease Effector T Cells In Vivo Open
Our findings suggest that Teff cell homing to the ileum through the axis α4β1-VCAM-1 is an essential and nonredundant pathway in CD in vivo, possibly affecting efficacy of clinical treatment with antiadhesion compounds.
View article: Blockade of αEβ7 integrin suppresses accumulation of CD8<sup>+</sup> and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo
Blockade of αEβ7 integrin suppresses accumulation of CD8<sup>+</sup> and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo Open
Objective Therapeutically targeting lymphocyte adhesion is of increasing relevance in IBD. Yet, central aspects of the action of antiadhesion compounds are incompletely understood. We investigated the role of αEβ7 and α4β7 integrins and th…