Daniela Scribano
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View article: Antibiotic-resistance and virulence-related genes in commercially bottled natural mineral waters
Antibiotic-resistance and virulence-related genes in commercially bottled natural mineral waters Open
View article: Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cells
Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cells Open
Background The airway epithelium represents the first line of defense of the lungs, functioning both as a physical barrier as well as an active immune modulator. However, in the last years, pneumonia caused by the opportunistic pathogen Ac…
View article: A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii
A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii Open
Introduction Acinetobacter baumannii exhibits high genomic plasticity, enabling it to acquire virulence factors and antibiotic resistance (AR). Understanding its evolutionary adaptations is crucial for developing effective therapeutic stra…
View article: Correction: The periplasmic protein HslJ is the firstline of defense against oxidative stress in Acinetobacter baumannii
Correction: The periplasmic protein HslJ is the firstline of defense against oxidative stress in Acinetobacter baumannii Open
View article: The periplasmic protein HslJ is the first-line of defense against oxidative stress in Acinetobacter baumannii
The periplasmic protein HslJ is the first-line of defense against oxidative stress in Acinetobacter baumannii Open
View article: Third‐Generation Cephalosporin‐Resistant Uropathogenic <i>Escherichia coli</i> From Community‐ and Hospital‐Acquired Infections Show High Level of Antibiotic Resistance and Specific Virulence Traits
Third‐Generation Cephalosporin‐Resistant Uropathogenic <i>Escherichia coli</i> From Community‐ and Hospital‐Acquired Infections Show High Level of Antibiotic Resistance and Specific Virulence Traits Open
Escherichia coli is a leading cause of both community‐acquired and nosocomial infections. In particular, E. coli is responsible for 90% of all uncomplicated urinary tract infections (UTIs) and 65% of complicated UTIs. Among complicated UTI…
View article: Anisakis extracellular vesicles elicit immunomodulatory and potentially tumorigenic outcomes on human intestinal organoids
Anisakis extracellular vesicles elicit immunomodulatory and potentially tumorigenic outcomes on human intestinal organoids Open
View article: <i>In vivo</i> evolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by <i>Klebsiella pneumoniae</i> sequence type 512
<i>In vivo</i> evolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by <i>Klebsiella pneumoniae</i> sequence type 512 Open
Carbapenemase-producing Klebsiella pneumoniae represents a major public health issue globally. Isolates with resistance to the newest drugs, like ceftazidime/avibactam (CZA), are increasingly reported. In this study, we analyzed the evolut…
View article: Acinetobacter baumannii OmpA-like porins: functional characterization of bacterial physiology, antibiotic-resistance, and virulence
Acinetobacter baumannii OmpA-like porins: functional characterization of bacterial physiology, antibiotic-resistance, and virulence Open
Acinetobacter baumannii is a critical opportunistic pathogen associated with nosocomial infections. The high rates of antibiotic-resistance acquisition make most antibiotics ineffective. Thus, new medical countermeasures are urgently neede…
View article: Reduced Gut Bacterial Diversity in Early Life Predicts Feeding Intolerance in Preterm Neonates
Reduced Gut Bacterial Diversity in Early Life Predicts Feeding Intolerance in Preterm Neonates Open
Microbiota plays a crucial role in intestinal maturation in preterm newborns. The clinical manifestation of the immaturity of the gastro-intestinal tract is called feeding intolerance (FI). This condition may resolve spontaneously or drama…
View article: Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders
Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders Open
Despite recent advances in prevention, detection and treatment, oral squamous cell carcinoma (OSCC) remains a global health concern, strongly associated with environmental and lifestyle risk factors and infection with oncogenic viruses. Me…
View article: The <i>Shigella flexneri</i> virulence factor apyrase is released inside eukaryotic cells to hijack host cell fate
The <i>Shigella flexneri</i> virulence factor apyrase is released inside eukaryotic cells to hijack host cell fate Open
Intestinal epithelial cells represent the first line of defense from invading enteric pathogens. During the course of infection, pro-inflammatory programmed cell death is an effective way to eliminate invading microbes and to create a loca…
View article: Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists
Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists Open
Selective antiadhesion antagonists of Uropathogenic Escherichia coli (UPEC) type-1 Fimbrial adhesin (FimH) are attractive alternatives for antibiotic therapies and prophylaxes against acute or recurrent urinary tract infections (UTIs) caus…
View article: The Acinetobacter baumannii model can explain the role of small non-coding RNAs as potential mediators of host-pathogen interactions
The Acinetobacter baumannii model can explain the role of small non-coding RNAs as potential mediators of host-pathogen interactions Open
Bacterial small RNAs (sRNAs) research has accelerated over the past decade, boosted by advances in RNA-seq technologies and methodologies for capturing both protein–RNA and RNA–RNA interactions. The emerging picture is that these regulator…
View article: Inflammatory Response in Caco-2 Cells Stimulated with Anisakis Messengers of Pathogenicity
Inflammatory Response in Caco-2 Cells Stimulated with Anisakis Messengers of Pathogenicity Open
Background: Anisakis spp. third-stage larvae (L3) are the causative agents of human zoonosis called anisakiasis. The accidental ingestion of L3 can cause acute and chronic inflammation at the gastric, intestinal, or ectopic levels. Despite…
View article: Outer membrane vesicles are the powerful cell-to-cell communication vehicles that allow bacteria to monitor extracellular milieu
Outer membrane vesicles are the powerful cell-to-cell communication vehicles that allow bacteria to monitor extracellular milieu Open
Existence of cell-to-cell communication strategies among bacteria (i.e., defined as inter-species, intra-species, and inter-kingdom crosstalk) reveals how genius they are (1,2).The common and well-studied language for bacterial communicati…
View article: Editorial: Current perspectives on Pseudomonas aeruginosa: epidemiology, virulence and contemporary strategies to combat multidrug-resistant (MDR) pathogens
Editorial: Current perspectives on Pseudomonas aeruginosa: epidemiology, virulence and contemporary strategies to combat multidrug-resistant (MDR) pathogens Open
EDITORIAL article Front. Microbiol., 26 July 2022Sec. Antimicrobials, Resistance and Chemotherapy https://doi.org/10.3389/fmicb.2022.975616
View article: Genetic Diversity of Antimicrobial Resistance and Key Virulence Features in Two Extensively Drug-Resistant Acinetobacter baumannii Isolates
Genetic Diversity of Antimicrobial Resistance and Key Virulence Features in Two Extensively Drug-Resistant Acinetobacter baumannii Isolates Open
In recent decades, Acinetobacter baumannii emerged as a major infective menace in healthcare settings due to scarce therapeutic options to treat infections. Therefore, undertaking genome comparison analyses of multi-resistant A. baumannii …
View article: Adaptive strategies of uropathogenic Escherichia coli CFT073: from growth in lab media to virulence during host cell adhesion
Adaptive strategies of uropathogenic Escherichia coli CFT073: from growth in lab media to virulence during host cell adhesion Open
View article: A World of Wonders: Interleukin-1 (IL-1) and IL-2 Families
A World of Wonders: Interleukin-1 (IL-1) and IL-2 Families Open
Human interleukins (ILs) are a collection of different biological molecules belonging to the group of cytokines, associated with various immune and non-immune systems and different signaling pathways. ILs contribute to the function of diff…
View article: Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way
Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way Open
Bacterial biofilms are a serious public-health problem worldwide. In recent years, the rates of antibiotic-resistant Gram-negative bacteria associated with biofilm-forming activity have increased worrisomely, particularly among healthcare-…
View article: Acinetobacter baumannii: An Ancient Commensal with Weapons of a Pathogen
Acinetobacter baumannii: An Ancient Commensal with Weapons of a Pathogen Open
Acinetobacter baumannii is regarded as a life-threatening pathogen associated with community-acquired and nosocomial infections, mainly pneumonia. The rise in the number of A. baumannii antibiotic-resistant strains reduces effective therap…
View article: Acinetobacter baumannii Targets Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAMs) for Invasion of Pneumocytes
Acinetobacter baumannii Targets Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAMs) for Invasion of Pneumocytes Open
This work shows for the first time that Acinetobacter baumannii binds to carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM5, and CEACAM6. This binding significantly enhances A. baumannii internalization within alv…
View article: SARS-CoV-2: Comparative analysis of different RNA extraction methods
SARS-CoV-2: Comparative analysis of different RNA extraction methods Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the COVID-19 pandemic. Although other diagnostic methods have been introduced, detection of viral genes on oro- and nasopharyngeal swabs by reverse-tran…
View article: Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions
Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions Open
Over the past decade, short non-coding microRNAs (miRNAs), including circulating and fecal miRNAs have emerged as important modulators of various cellular processes by regulating the expression of target genes. Recent studies revealed the …
View article: The Global Emergency of Novel Coronavirus (SARS-CoV-2): An Update of the Current Status and Forecasting
The Global Emergency of Novel Coronavirus (SARS-CoV-2): An Update of the Current Status and Forecasting Open
Over the past two decades, there have been two major outbreaks where the crossover of animal Betacoronaviruses to humans has resulted in severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavi…
View article: FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against Uropathogens
FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against Uropathogens Open
Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic strategy has become less effective in the treatment of uropathog…
View article: d-Mannose Treatment neither Affects Uropathogenic Escherichia coli Properties nor Induces Stable FimH Modifications
d-Mannose Treatment neither Affects Uropathogenic Escherichia coli Properties nor Induces Stable FimH Modifications Open
Urinary tract infections (UTIs) are mainly caused by uropathogenic Escherichia coli (UPEC). Acute and recurrent UTIs are commonly treated with antibiotics, the efficacy of which is limited by the emergence of antibiotic resistant strains. …
View article: A simple, fast and reliable scan-based technique as a novel approach to quantify intracellular bacteria
A simple, fast and reliable scan-based technique as a novel approach to quantify intracellular bacteria Open
View article: Insights into the Periplasmic Proteins of Acinetobacter baumannii AB5075 and the Impact of Imipenem Exposure: A Proteomic Approach
Insights into the Periplasmic Proteins of Acinetobacter baumannii AB5075 and the Impact of Imipenem Exposure: A Proteomic Approach Open
Carbapenem-resistant Acinetobacter baumannii strains cause life-threatening infections due to the lack of therapeutic options. Although the main mechanisms underlying antibiotic-resistance have been extensively studied, the general respons…