Daniela Spano
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View article: Development and characterization of a membrane-permeant GRASP65-mimetic peptide that inhibits Golgi unlinking and cell cycle progression
Development and characterization of a membrane-permeant GRASP65-mimetic peptide that inhibits Golgi unlinking and cell cycle progression Open
The Golgi complex is central to cellular homeostasis and serves as a key processing and sorting hub for protein trafficking. In many cell types, the Golgi complex is organized as interconnected stacks of cisternae, forming a structure know…
View article: The role of Golgi complex proteins in cell division and consequences of their dysregulation
The role of Golgi complex proteins in cell division and consequences of their dysregulation Open
The GC (Golgi complex) plays a pivotal role in the trafficking and sorting of proteins and lipids until they reach their final destination. Additionally, the GC acts as a signalling hub to regulate a multitude of cellular processes, includ…
View article: Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer Therapy
Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer Therapy Open
Ubiquitination is a reversible post-translational modification based on the chemical addition of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination can alter the molecular functions of tagged substr…
View article: Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells
Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells Open
Background. The C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor and as a fission inducing protein required for membrane trafficking and Golgi complex p…
View article: Golgi Complex: A Signaling Hub in Cancer
Golgi Complex: A Signaling Hub in Cancer Open
The Golgi Complex is the central hub in the endomembrane system and serves not only as a biosynthetic and processing center but also as a trafficking and sorting station for glycoproteins and lipids. In addition, it is an active signaling …
View article: Editorial: Combinatorial Approaches for Cancer Treatment: From Basic to Translational Research
Editorial: Combinatorial Approaches for Cancer Treatment: From Basic to Translational Research Open
EDITORIAL article Front. Oncol., 02 February 2022Sec. Pharmacology of Anti-Cancer Drugs Volume 12 - 2022 | https://doi.org/10.3389/fonc.2022.842114
View article: PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane
PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane Open
Significance Proteins are modified by many posttranslational modifications (PTMs) with crucial regulatory functions. A PTM attracting increasing interest is ADP-ribosylation, capable of altering crucial cellular targets. We show that mono-…
View article: Corrigendum: Combinatorial Strategies to Target Molecularand Signaling Pathways to Disarm Cancer Stem Cells
Corrigendum: Combinatorial Strategies to Target Molecularand Signaling Pathways to Disarm Cancer Stem Cells Open
[This corrects the article DOI: 10.3389/fonc.2021.689131.].
View article: Combinatorial Strategies to Target Molecular and Signaling Pathways to Disarm Cancer Stem Cells
Combinatorial Strategies to Target Molecular and Signaling Pathways to Disarm Cancer Stem Cells Open
Cancer is an urgent public health issue with a very huge number of cases all over the world expected to increase by 2040. Despite improved diagnosis and therapeutic protocols, it remains the main leading cause of death in the world. Cancer…
View article: Shp1 in Solid Cancers and Their Therapy
Shp1 in Solid Cancers and Their Therapy Open
Shp1 is a cytosolic tyrosine phosphatase that regulates a broad range of cellular functions and targets, modulating the flow of information from the cell membrane to the nucleus. While initially studied in the hematopoietic system, researc…
View article: PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 controls the transport of E-cadherin
PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 controls the transport of E-cadherin Open
ADP-ribosylation is a post-translational modification involved in physiological and pathological events catalyzed by Poly-ADP-Ribosyl-Polymerase (PARP) enzymes. Substrates of this reaction have been identified by mass-spectrometry, but the…
View article: Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2
Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2 Open
The Golgi apparatus is composed of stacks of cisternae laterally connected by tubules to form a ribbon-like structure. At the onset of mitosis, the Golgi ribbon is broken down into discrete stacks, which then undergo further fragmentation.…