Daniela Uberti
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View article: Biochemical, Biological, and Clinical Properties of γ-Oryzanol
Biochemical, Biological, and Clinical Properties of γ-Oryzanol Open
γ-Oryzanol is a complex mixture of ferulic acid esters of phytosterols and triterpene alcohols predominantly found in rice bran. It exhibits a wide range of biological activities, including antioxidant, anti-inflammatory, and lipid-lowerin…
View article: Sleep phenotypes and mental disorders: analysis of causality with two-sample Mendelian randomization
Sleep phenotypes and mental disorders: analysis of causality with two-sample Mendelian randomization Open
Introduction Sleep health is s an essential aspect of a healthy lifestyle, and sleep problems are prevalent among individuals with mental disorders. However, this relationship appears complex to explore with classic observational studies, …
View article: Effects of methylglyoxal on intestine and microbiome composition in aged mice
Effects of methylglyoxal on intestine and microbiome composition in aged mice Open
These findings highlight how dietary MGO can affect intestinal balance, providing valuable insights into the potential links between glycotoxins, gut microbiota, and overall gut functionality.
View article: The Bioactive Gamma-Oryzanol from Oryza sativa L. Promotes Neuronal Differentiation in Different In Vitro and In Vivo Models
The Bioactive Gamma-Oryzanol from Oryza sativa L. Promotes Neuronal Differentiation in Different In Vitro and In Vivo Models Open
Gamma-oryzanol (ORY), found in rice (Oryza sativa L.), is a mixture of ferulic acid esters with triterpene alcohols, well-known for its antioxidant and anti-inflammatory properties. Our past research demonstrated its positive impact on cog…
View article: Ecotoxicological evaluation of an aqueous phytoextract of Melia azedarach L.
Ecotoxicological evaluation of an aqueous phytoextract of Melia azedarach L. Open
Melia azedarach L. is a Meliaceae that has shown important insecticidal activities. However, few researchers have extensively studied the toxicology of aqueous extracts of M. azedarach (MAE). Therefore, the main objective of this study was…
View article: Exploring the Anti-Inflammatory and Antioxidant Potential, Metabolite Composition and Inorganic Profile of Cistus monspeliensis L. Aerial Parts and Roots
Exploring the Anti-Inflammatory and Antioxidant Potential, Metabolite Composition and Inorganic Profile of Cistus monspeliensis L. Aerial Parts and Roots Open
This work focuses on Cistus monspeliensis L. aerial parts (AP) and roots (R) extracts, investigating the anti-inflammatory and antioxidant potential of the two organs in comparison. At dosages between 1.56 and 6.25 µg/mL, both extracts sho…
View article: The performance of AlzoSure® Predict in stratifying the risk to experience a significant cognitive deterioration, due to Alzheimer’s Disease
The performance of AlzoSure® Predict in stratifying the risk to experience a significant cognitive deterioration, due to Alzheimer’s Disease Open
Background Treatments for patients with Alzheimer’s Disease (AD) are now available, and are associated with certain risks. There is an increased need from providers, to have tools that will aid in clinical decision‐making. Method The AlzoS…
View article: An Overview of Data Integration in Neuroscience With Focus on Alzheimer's Disease
An Overview of Data Integration in Neuroscience With Focus on Alzheimer's Disease Open
This work represents the first attempt to provide an overview of how to face data integration as the result of a dialogue between neuroscientists and computer scientists. Indeed, data integration is fundamental for studying complex multifa…
View article: The Bright Side of Psychedelics: Latest Advances and Challenges in Neuropharmacology
The Bright Side of Psychedelics: Latest Advances and Challenges in Neuropharmacology Open
The need to identify effective therapies for the treatment of psychiatric disorders is a particularly important issue in modern societies. In addition, difficulties in finding new drugs have led pharmacologists to review and re-evaluate so…
View article: AlzoSure® Predict, a simple minimally‐invasive blood test to predict the early onset of Alzheimer’s disease before the manifestation of clinical symptoms
AlzoSure® Predict, a simple minimally‐invasive blood test to predict the early onset of Alzheimer’s disease before the manifestation of clinical symptoms Open
Background Ongoing research seeks to identify blood‐based biomarkers able to predict the onset and progression of Alzheimer’s disease (AD). AlzoSure® Predict is a rapid, minimally‐invasive blood test that predicts the early onset of AD up …
View article: Comparative Effects of Four Plant Growth Regulators on Yield and Field Performance of Crocus sativus L.
Comparative Effects of Four Plant Growth Regulators on Yield and Field Performance of Crocus sativus L. Open
The effects of four plant growth regulators on Crocus sativus L. (saffron) yield and performance were studied in two consecutive years under field conditions. Saffron corms were immersed in solutions of gibberellic acid (GA3), salicylic ac…
View article: Different Seasonal Collections of Ficus carica L. Leaves Diversely Modulate Lipid Metabolism and Adipogenesis in 3T3-L1 Adipocytes
Different Seasonal Collections of Ficus carica L. Leaves Diversely Modulate Lipid Metabolism and Adipogenesis in 3T3-L1 Adipocytes Open
Due to the high prevalence of obesity and type 2 diabetes, adipogenesis dysfunction and metabolic disorders are common features in the elderly population. Thus, the identification of novel compounds with anti-adipogenic and lipolytic effec…
View article: Molecular Characterization of a New Ecotype of Holoparasitic Plant Orobanche L. on Host Weed Xanthium spinosum L.
Molecular Characterization of a New Ecotype of Holoparasitic Plant Orobanche L. on Host Weed Xanthium spinosum L. Open
A species of Orobanche was observed on spiny cocklebur (Xanthium spinosum) for the first time in Iran and tentatively was named IR-Iso.This study was conducted to make a phylogenetic analysis of the Orobanche using 5.8S rRNA region sequenc…
View article: Biochemical and Botanical Aspects of Allium sativum L. Sowing
Biochemical and Botanical Aspects of Allium sativum L. Sowing Open
The main aim of this study was to evaluate the yield and compliance of selected Iranian garlic (Allium sativum L.) cultivars, including Tuyserkan (TSN), Heydareh (HDH), Mouien (MUN), and Taroom (TRM), during two growing seasons. The TRM cu…
View article: A Conformational Variant of p53 (U-p53AZ) as Blood-Based Biomarker for the Prediction of the Onset of Symptomatic Alzheimer's Disease
A Conformational Variant of p53 (U-p53AZ) as Blood-Based Biomarker for the Prediction of the Onset of Symptomatic Alzheimer's Disease Open
These findings support use of U-p53AZ as blood-based biomarker predicting whether individuals would reach neuropsychologically-defined AD within six years prior to AD diagnosis. Integration of U-p53AZ in screening processes could support r…
View article: Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the Literature
Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the Literature Open
Our understanding of Alzheimer’s disease (AD) pathogenesis has developed with several hypotheses over the last 40 years, including the Amyloid and Tau hypotheses. More recently, the p53 protein, well-known as a genome guardian, has gained …
View article: Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the Literature<strong> </strong>
Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the Literature<strong> </strong> Open
Our understanding of Alzheimer’s disease (AD) pathogenesis has developed with several hypotheses over the last 40 years, including the Amyloid and Tau hypotheses, respectively. More recently, the p53 protein, well-known as ‘the…
View article: A conformational variant of p53 (U-p53<sup>AZ</sup>) as blood-based biomarker for the prediction of the onset of symptomatic Alzheimer’s disease
A conformational variant of p53 (U-p53<sup>AZ</sup>) as blood-based biomarker for the prediction of the onset of symptomatic Alzheimer’s disease Open
Background Ongoing research seeks to identify blood-based biomarkers able to predict the onset and progression of Alzheimer’s disease (AD). A potential biomarker is the unfolded conformational variant of p53, previously observed in individ…
View article: Phytochemical Analysis and Anti-Inflammatory Activity of Different Ethanolic Phyto-Extracts of Artemisia annua L.
Phytochemical Analysis and Anti-Inflammatory Activity of Different Ethanolic Phyto-Extracts of Artemisia annua L. Open
Artemisia annua L. (AA) has shown for many centuries important therapeutic virtues associated with the presence of artemisinin (ART). The aim of this study was to identify and quantify ART and other secondary metabolites in ethanolic extra…
View article: Potential and Limits of Cannabinoids in Alzheimer’s Disease Therapy
Potential and Limits of Cannabinoids in Alzheimer’s Disease Therapy Open
Alzheimer’s disease (AD) is a detrimental brain disorder characterized by a gradual cognitive decline and neuronal deterioration. To date, the treatments available are effective only in the early stage of the disease. The AD etiology has n…
View article: Performance of a Non-Invasive Blood Test for a Conformational Variant of p53 to Predict Alzheimer’s Disease Within 6 Years of Clinical Diagnosis
Performance of a Non-Invasive Blood Test for a Conformational Variant of p53 to Predict Alzheimer’s Disease Within 6 Years of Clinical Diagnosis Open
Background: Research continues to search for blood-based biomarkers sensitive to Alzheimer’s disease (AD) pathology during the initial stages when symptoms of cognitive decline are not yet apparent. A blood-based biomarker candidate …
View article: Discovery of Simple Blood-Based Test to Predict Early Onset of Alzheimer’s Using Standard Clinical Mass Spectrometry Platforms
Discovery of Simple Blood-Based Test to Predict Early Onset of Alzheimer’s Using Standard Clinical Mass Spectrometry Platforms Open
Despite the increasing number of individuals affected by Alzheimer’s disease (AD) every year, no effective therapy has been developed to treat this neurodegenerative disease yet. The current methods for AD diagnosis are effective for…
View article: A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages
A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages Open
Early diagnosis of Alzheimer’s disease (AD) is a crucial starting point in disease management. Blood-based biomarkers could represent a considerable advantage in providing AD-risk information in primary care settings. Here, we report new d…
View article: Unfolded P53 as a novel lead biomarker for Alzheimer’s disease diagnosis
Unfolded P53 as a novel lead biomarker for Alzheimer’s disease diagnosis Open
Background Blood‐based biomarkers represent a promising choice for early Alzheimer’s disease (AD) diagnosis and for evaluating the efficacy of novel disease‐modifying therapeutics. The complexity of the disease, where multiple pathogenetic…
View article: Rage-txnip Axis Drives Inflammation in Alzheimer`s by Targeting aβ to Mitochondria in Microglia
Rage-txnip Axis Drives Inflammation in Alzheimer`s by Targeting aβ to Mitochondria in Microglia Open
Alzheimer’s disease (AD) is the most common form of dementia characterized by progressive memory loss and cognitive decline. Although neuroinflammation and oxidative stress are well-recognized features of AD, their correlations with the ea…
View article: Impact of COVID-19 on Alzheimer’s Disease Risk: Viewpoint for Research Action
Impact of COVID-19 on Alzheimer’s Disease Risk: Viewpoint for Research Action Open
In the middle of the coronavirus disease 19 (COVID-19) outbreak, the main efforts of the scientific community are rightly all focused on identifying efficient pharmacological treatments to cure the acute severe symptoms and developing a re…