Daniele Borsetto
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View article: First-in-human pilot study of snapshot multispectral endoscopy for delineation of pituitary adenoma
First-in-human pilot study of snapshot multispectral endoscopy for delineation of pituitary adenoma Open
The MSI endoscope holds the potential to differentiate adenoma tissue and healthy pituitary. With further development, MSI endoscopy could enable real-time label-free delineation of tumors during surgery, based on quantitative thresholds, …
View article: 28 Clinical Features and Outcomes of Objective Pulsatile Tinnitus
28 Clinical Features and Outcomes of Objective Pulsatile Tinnitus Open
Introduction Pulsatile tinnitus can be subjective or objective (OPT), with significant delay to diagnosis OPT aetiology is poorly characterised, and very little is known about the risk of serious pathology for patients with OPT, with diagn…
View article: Current and emerging approaches to cochlear immunosuppression with translation to human inner ear stem cell therapy: A systematic review
Current and emerging approaches to cochlear immunosuppression with translation to human inner ear stem cell therapy: A systematic review Open
Hearing loss is a significant health burden across all stages of life. One in 5 people suffer hearing loss, with 5% of the world’s population experiencing disabling hearing loss. A large proportion of this loss is the consequence of damage…
View article: Prognostic value of changes in pre- and postoperative inflammatory blood markers in HPV-negative head and neck squamous cell carcinomas
Prognostic value of changes in pre- and postoperative inflammatory blood markers in HPV-negative head and neck squamous cell carcinomas Open
Our results support that pre- and postoperative NLR and LMR can be useful in identifying patients at risk of local, regional, or distant recurrence who may require closer follow-up or more aggressive treatment.
View article: 3D Scanning of Surgical Specimens to Improve Communication Between Surgeon and Pathologist: A Head and Neck Pilot Study
3D Scanning of Surgical Specimens to Improve Communication Between Surgeon and Pathologist: A Head and Neck Pilot Study Open
Background/Objectives Successful surgical outcomes in head and neck cancer depend on the accurate identification of resection margins. Effective communication between surgeons and pathologists is critical, but is often jeopardised by chall…
View article: Quality of Information Provided by Artificial Intelligence Chatbots Surrounding the Reconstructive Surgery for Head and Neck Cancer: A Comparative Analysis Between <scp>ChatGPT4</scp> and Claude2
Quality of Information Provided by Artificial Intelligence Chatbots Surrounding the Reconstructive Surgery for Head and Neck Cancer: A Comparative Analysis Between <span>ChatGPT4</span> and Claude2 Open
Introduction Artificial Intelligences (AIs) are changing the way information is accessed and consumed globally. This study aims to evaluate the information quality provided by AIs ChatGPT4 and Claude2 concerning reconstructive surgery for …
View article: Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal
Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal Open
Background: There is no consensus regarding the indication for postoperative radiotherapy (PORT) for T1- and T2-classified squamous cell carcinoma (SCC) of the external auditory canal (EAC) even with negative surgical margins. This study a…
View article: Effect of Cochlear Implantation on Air Conduction and Bone Conduction Elicited Vestibular Evoked Myogenic Potentials—A Scoping Review
Effect of Cochlear Implantation on Air Conduction and Bone Conduction Elicited Vestibular Evoked Myogenic Potentials—A Scoping Review Open
Background/Objectives: Cochlear implantation (CI) is an effective intervention for individuals with severe to profound hearing loss; however, it may impact vestibular function due to its proximity to related anatomical structures. Vestibul…
View article: Revised Classification of Inner Ear Schwannomas
Revised Classification of Inner Ear Schwannomas Open
Over the past two decades, there has been increasing interest in the diagnosis and management of schwannomas of the inner ear including hearing rehabilitation with cochlear implants. However, tumor nomenclature and classification within th…
View article: Intraoperative Detection of Extracochlear Electrodes Using Stimulation Current Induced Non‐Stimulating Electrode Voltage ( <scp>SCINSEV</scp> ) Measures (Transimpedance Measures)—A Case Series
Intraoperative Detection of Extracochlear Electrodes Using Stimulation Current Induced Non‐Stimulating Electrode Voltage ( <span>SCINSEV</span> ) Measures (Transimpedance Measures)—A Case Series Open
Cochlear implants (CIs) are prosthetic devices used to restore hearing sensation in people with severe to profound sensorineural hearing loss [1]. The success of the CI surgery relies on the surgical placement of the electrodes within the …
View article: Intraoperative surgical navigation as a precision medicine tool in sinonasal and craniofacial oncologic surgery
Intraoperative surgical navigation as a precision medicine tool in sinonasal and craniofacial oncologic surgery Open
The current standard method to evaluate disease extension and margin status is associated with a spatial error approaching 1 cm, which could affect treatment precision and outcomes. The study emphasizes the potential of SN in increasing sp…
View article: Immunosuppression in stem cell clinical trials of neural and retinal cell types: A systematic review
Immunosuppression in stem cell clinical trials of neural and retinal cell types: A systematic review Open
Background Pharmacologic immunosuppression regimes are commonly employed in stem cell clinical trials to mitigate host immune rejection and promote survival and viability of transplanted cells. Immunosuppression and cell survival has been …
View article: Multi-Magnet Cochlear Implant Technology and Magnetic Resonance Imaging: The Safety Issue
Multi-Magnet Cochlear Implant Technology and Magnetic Resonance Imaging: The Safety Issue Open
Despite the spread of novel-generation cochlear-implant (CI) magnetic systems, access to magnetic resonance imaging (MRI) for CI recipients is still limited due to safety concerns. The aim of this study is to assess and record the experien…
View article: Cochlear implant cost analysis in adults: a European narrative review
Cochlear implant cost analysis in adults: a European narrative review Open
Purpose The aim of this study was to provide an updated European narrative review spanning the last decade, focusing on the cost-effectiveness of cochlear implants (CIs) for adults with severe to profound post-lingual hearing loss. Methods…
View article: A scoping review on the clinical effectiveness of Trans-Impedance Matrix (TIM) measurements in detecting extracochlear electrodes and tip fold overs in Cochlear Ltd devices
A scoping review on the clinical effectiveness of Trans-Impedance Matrix (TIM) measurements in detecting extracochlear electrodes and tip fold overs in Cochlear Ltd devices Open
Background Extrusion of electrodes outside the cochlea and tip fold overs may lead to suboptimal outcomes in cochlear implant (CI) recipients. Intraoperative measures such as Trans-Impedance Matrix (TIM) measurements may enable clinicians …
View article: A Multicenter Validity Study of Four Smartphone Hearing Test Apps in Optimized and Home Environments
A Multicenter Validity Study of Four Smartphone Hearing Test Apps in Optimized and Home Environments Open
Objective Pure tone audiometry (PTA) is the gold standard for hearing assessment. However, it requires access to specialized equipment. Smartphone audiometry applications (apps) have been developed to perform automated threshold audiometry…
View article: Otological Planning Software—OTOPLAN: A Narrative Literature Review
Otological Planning Software—OTOPLAN: A Narrative Literature Review Open
The cochlear implant (CI) is a widely accepted option in patients with severe to profound hearing loss receiving limited benefit from traditional hearing aids. CI surgery uses a default setting for frequency allocation aiming to reproduce …
View article: Antibiotics versus non‐antibiotic treatments for acute otitis externa: A systematic review and meta‐analysis
Antibiotics versus non‐antibiotic treatments for acute otitis externa: A systematic review and meta‐analysis Open
Background Otitis externa is a condition causing inflammation of the outer ear canal, which presents with itching, discharge and pain. Most cases of acute otitis externa are caused by bacterial infection and are thus treated with antibioti…
View article: Meningitis Risk in Patients with Inner Ear Malformations after Cochlear Implants: A Systematic Review and Meta-Analysis
Meningitis Risk in Patients with Inner Ear Malformations after Cochlear Implants: A Systematic Review and Meta-Analysis Open
Objective The objective of this study is to determine the rate of postoperative meningitis after cochlear implantation in those with inner ear malformations (IEMs) via meta-analysis. Data sources Medline, EMBASE, and the Cochrane Library. …
View article: The prognostic-nutritional index in HPV-negative head and neck squamous cell carcinoma treated with upfront surgery: a multi-institutional series
The prognostic-nutritional index in HPV-negative head and neck squamous cell carcinoma treated with upfront surgery: a multi-institutional series Open
PNI represents a reliable prognostic tool providing an independent measure of pre-operative immuno-metabolic performance. Its validity is supported by the independent prognostic role of albuminaemia and lymphocyte count, from which it is d…
View article: TERT promoter mutations in head and neck squamous cell carcinoma: A systematic review and meta-analysis on prevalence and prognostic significance
TERT promoter mutations in head and neck squamous cell carcinoma: A systematic review and meta-analysis on prevalence and prognostic significance Open
TERT promoter mutations were mainly topographically restricted to oral cavity cancer. -124 C > T was the most common TERT promoter mutation and was significantly associated to worse outcome in HNSCC.
View article: Frequency of electrode migration after cochlear implantation in the early postoperative period. What are associated risk factors?
Frequency of electrode migration after cochlear implantation in the early postoperative period. What are associated risk factors? Open
Objectives To estimate the prevalence of, and risk factors associated with electrode migration (EM) in cochlear implant (CI) recipients. Design Historical cohort study of all CIs performed between 1 January 2018 and 1 August 2021 in a sing…
View article: Recurrence in cholesteatoma surgery: what have we learnt and where are we going? A narrative review
Recurrence in cholesteatoma surgery: what have we learnt and where are we going? A narrative review Open
Treatment of cholesteatoma is surgical and has historically encompassed two main techniques: canal wall up (CWU) and canal wall down (CWD) tympanoplasty. Follow-up for cholesteatoma is still debated and can be either radiological or with s…
View article: Psychophysical assessment of olfactory and gustatory function in post‐mild COVID‐19 patients: A matched case‐control study with 2‐year follow‐up
Psychophysical assessment of olfactory and gustatory function in post‐mild COVID‐19 patients: A matched case‐control study with 2‐year follow‐up Open
Background The aim of this study was to psychophysically evaluate the prevalence of smell and taste dysfunction 2 years after mildly symptomatic severe acute respiratory syndrome–coronavirus‐2 (SARS‐CoV‐2) infection compared to that observ…