Explanipedia

A fixed mutation in the respiratory complex I impairs mitochondrial bioenergetics in the endangered Apennine brown bear Open

Emiliano Trucchi, Silvia Fuselli, Nunzio Perta, Simone Patergnani, Alberto Danese , et al. · 2025

Effective conservation genomics of endangered species requires realistic understanding of the fitness consequences caused by the accumulation of deleterious mutations in declining populations. We experimentally investigated three mutations…

Molecular targeting of the deubiquitinase USP14 to circumvent cisplatin resistance in ovarian carcinoma and identification of novel inhibitors Open

Cristina Corno, Debora Russo, Francesco Pignotti, Francesca De Giorgi, Ilaria Penna , et al. · 2025

Aim: This study aims to investigate the biological role of the proteasome-associated deubiquitinase ubiquitin-specific protease 14 (USP14) in ovarian carcinoma drug resistance and to identify novel USP14 inhibitors (USP14i) for further pre…

Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism Open

Mattia D’Agostino, Angelita Simonetti, Stefano Motta, Philippe Wolff, Alice Romagnoli , et al. · 2024

Translational takedown: CYFIP1-based peptidomimetic against cancer and fragile X Syndrome Open

Alice Romagnoli, Stefano Raniolo, Alessandro Gori, Anastasia De Luca, Vittorio Limongelli , et al. · 2024

Hydroxytyrosol Counteracts Triple Negative Breast Cancer Cell Dissemination via Its Copper Complexing Properties Open

Nunzio Perta, Laura Torrieri Di Tullio, Elisa Cugini, P. Fattibene, Maria Cristina Rapanotti , et al. · 2023

Polyphenols have gained increasing attention for their therapeutic potential, particularly in conditions like cancer, due to their established antioxidant and anti-inflammatory properties. Recent research highlights their ability to bind t…

Structural basis of dimerization of chemokine receptors CCR5 and CXCR4 Open

Daniele Di Marino, Paolo Conflitti, Stefano Motta, Vittorio Limongelli · 2023

G protein-coupled receptors (GPCRs) are prominent drug targets responsible for extracellular-to-intracellular signal transduction. GPCRs can form functional dimers that have been poorly characterized so far. Here, we show the dimerization …

Evolutionary dynamics of genome size and content during the adaptive radiation of Heliconiini butterflies Open

Francesco Cicconardi, Edoardo Milanetti, Érika C. Pinheiro de Castro, Anyi Mazo‐Vargas, Steven M. Van Belleghem , et al. · 2023

Structural basis of dimerization of chemokine receptors CCR5 and CXCR4 Open

Daniele Di Marino, Paolo Conflitti, Stefano Motta, Vittorio Limongelli · 2023

This is the minimum dataset of the Nature Communication paper "Structural basis of dimerization of chemokine receptors CCR5 and CXCR4". This repository is composed of two zipped archives. The first archive, "Dataset Minimum", contains all …

Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization Open

Vittoria Mariano, Alexandros K. Kanellopoulos, Claudia Ricci, Daniele Di Marino, Sarah C. Borrie , et al. · 2023

Unlocking the Potential of Field Effect Transistor (FET) Biosensors: A Perspective on Methodological Advances in Computational and Molecular Biology Open

Jesmina Rexha, Nunzio Perta, Agnese Roscioni, Stefano Motta, Anna La Teana , et al. · 2023

Field‐effect transistor (FET)‐based sensors are increasingly gaining relevance in diagnostic, healthcare, and environmental monitoring applications. A FET operates by transducing chemical interactions between a surface‐immobilized biorecep…

Portable High-Accuracy Wireless Acquisition System for Graphene-Based Sensors Open

Giorgio Biagetti, Paolo Crippa, Michele Alessandrini, Daniele Di Marino · 2023

Graphene field-effect transistors (gFETs) are gaining popularity for the realization of biological sensors as their graphene active area provides a convenient basis for attaching organic substances, such as appropriately engineered recepto…

Evolutionary dynamics of genome size and content during the adaptive radiation of Heliconiini butterflies Open

Francesco Cicconardi, Edoardo Milanetti, Érika C. Pinheiro de Castro, Anyi Mazo‐Vargas, Steven M. Van Belleghem , et al. · 2023

Comparative genomics of Heliconiini butterflies. The data contains some information about data used in the paper

Impact of Weather Data Temporal Resolution on Machine Learning Based Solar Energy Generation Predictions with a Focus on Sunrise and Sunset Times Open

Firat Y. Testik, Daniele Di Marino, Laura Ortega, Tuan Q. Le, Murat Caner Testik · 2023

SARS-CoV-2 multi-variant rapid detector based on graphene transistor functionalized with an engineered dimeric ACE2 receptor Open

Alice Romagnoli, Mattia D’Agostino, Eleonora Pavoni, Chiara Ardiccioni, Stefano Motta , et al. · 2022

AKT-driven epithelial-mesenchymal transition is affected by copper bioavailability in HER2 negative breast cancer cells via a LOXL2-independent mechanism Open

Alessandra Vitaliti, Ilenia Roccatani, Egidio Iorio, Nunzio Perta, Angelo Gismondi , et al. · 2022

Evolutionary dynamics of genome size and content during the adaptive radiation of Heliconiini butterflies Open

Francesco Cicconardi, Edoardo Milanetti, Érika De Castro, Anyi Mazo‐Vargas, Steven M. Van Belleghem , et al. · 2022

Heliconius butterflies, a speciose genus of Müllerian mimics, represent a classic example of an adaptive radiation involving a range of derived dietary, life history, physiological and neural traits. However, key lineages within the genus,…

Selection-driven adaptation to the extreme Antarctic environment in the Emperor penguin Open

Federica Pirri, Lino Ometto, Silvia Fuselli, Flávia A. N. Fernandes, Lorena Ancona , et al. · 2022

Structural–Functional Relationship of the Ribonucleolytic Activity of aIF5A from Sulfolobus solfataricus Open

Alice Romagnoli, Paolo Moretti, Mattia D’Agostino, Jesmina Rexha, Nunzio Perta , et al. · 2022

The translation factor IF5A is a highly conserved protein playing a well-recognized and well-characterized role in protein synthesis; nevertheless, some of its features as well as its abundance in the cell suggest that it may perform addit…

Evolutionary dynamics of genome size and content during the adaptive radiation of Heliconiini butterflies Open

Francesco Cicconardi, Edoardo Milanetti, Érika C. Pinheiro de Castro, Anyi Mazo‐Vargas, Steven M. Van Belleghem , et al. · 2022

Heliconius butterflies, a speciose genus of Müllerian mimics, represent a classic example of an adaptive radiation that includes a range of derived dietary, life history, physiological and neural traits. However, key lineages within the ge…

Transcriptional Contribution of Transposable Elements in Relation to Salinity Conditions in Teleosts and Silencing Mechanisms Involved Open

Elisa Carotti, Federica Carducci, Samuele Greco, Marco Gerdol, Daniele Di Marino , et al. · 2022

Fish are an interesting taxon comprising species adapted to a wide range of environments. In this work, we analyzed the transcriptional contribution of transposable elements (TEs) in the gill transcriptomes of three fish species exposed to…

The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer’s disease Open

Stefano Musardo, Sebastien Therin, Silvia Pelucchi, Laura D’Andrea, Ramona Stringhi , et al. · 2022

Molecular regulations of circadian rhythm and implications for physiology and diseases Open

Francesca Fagiani, Daniele Di Marino, Alice Romagnoli, Cristina Travelli, Davide Voltan , et al. · 2022

Pin1 as Molecular Switch in Vascular Endothelium: Notes on Its Putative Role in Age-Associated Vascular Diseases Open

Francesca Fagiani, Marieva Vlachou, Daniele Di Marino, Ilaria Canobbio, Alice Romagnoli , et al. · 2021

By controlling the change of the backbones of several cellular substrates, the peptidyl-prolyl cis-trans isomerase Pin1 acts as key fine-tuner and amplifier of multiple signaling pathways, thereby inducing several biological consequences, …

The Use of Peptides in the Treatment of Fragile X Syndrome: Challenges and Opportunities Open

Alice Romagnoli, Daniele Di Marino · 2021

Fragile X Syndrome (FXS) is the most frequent cause of inherited intellectual disabilities and autism spectrum disorders, characterized by cognitive deficits and autistic behaviors. The silencing of the Fmr1 gene and consequent lack of FMR…

SARS-CoV-2 multi-variant graphene biosensor based on engineered dimeric ACE2 receptor Open

Mattia D’Agostino, Eleonora Pavoni, Alice Romagnoli, Chiara Ardiccioni, Stefano Motta , et al. · 2021

Fast, reliable and point-of-care systems to detect the SARS-CoV-2 infection are crucial to contain viral spreading and to adopt timely clinical treatments. Many of the rapid detection tests currently in use are based on antibodies that bin…

Control of the eIF4E activity: structural insights and pharmacological implications Open

Alice Romagnoli, Mattia D’Agostino, Chiara Ardiccioni, Cristina Maracci, Stefano Motta , et al. · 2021

The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA translation has been clearly assessed in the last decades. eIF4E function is essential for numerous physiological processes, such as protein synthe…

Author Correction: Brain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin association Open

Gilda Stefanelli, Anna Gandaglia, Mario Costa, Manjinder S. Cheema, Daniele Di Marino , et al. · 2021

Table of Contents Open

Ursula Loizides‐Mangold, Marcello Dominici, Tony Manderson, Menico Rizzi, James A. Robertson , et al. · 2021

Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy Open

Alice Romagnoli, Cristina Maracci, Mattia D’Agostino, Anna La Teana, Daniele Di Marino · 2021

Ovarian carcinoma is one of the most common causes for cancer death in women; lack of early diagnosis and acquired resistance to platinum-based chemotherapy account for its poor prognosis and high mortality rate. As with other cancer types…

Insights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase in Sulfolobus solfataricus: A Thermophilic Model for the Design of New Hypusination Inhibitors Open

Mattia D’Agostino, Stefano Motta, Alice Romagnoli, Patrick Orlando, Luca Tiano , et al. · 2020

Translation factor 5A (eIF5A) is one of the most conserved proteins involved in protein synthesis. It plays a key role during the elongation of polypeptide chains, and its activity is critically dependent on hypusination, a post-translatio…

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