Daniele Musiani
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View article: Nuclear NAD<sup>+</sup> homeostasis is essential for naive and chemoresistant <i>BRCA1/2</i>-deficient tumor survival
Nuclear NAD<sup>+</sup> homeostasis is essential for naive and chemoresistant <i>BRCA1/2</i>-deficient tumor survival Open
Resistance to PARP inhibitors (PARPi) is emerging as the major obstacle to their effectiveness for the treatment of BRCA1/2 -mutated, also referred as homologous recombination (HR)-deficient, tumors (HRD). Over the years, mechanistic studi…
View article: PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin Open
View article: Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation Open
View article: hmSEEKER: Identification of hmSILAC Doublets in MaxQuant Output Data
hmSEEKER: Identification of hmSILAC Doublets in MaxQuant Output Data Open
Heavy methyl Stable Isotope Labeling with Amino acids in Cell culture (hmSILAC) is a metabolic labeling strategy employed in proteomics to increase the confidence of global identification of methylated peptides by MS. However, to this day,…
View article: Chromatin proteomics reveals novel combinatorial histone modification signatures that mark distinct subpopulations of macrophage enhancers
Chromatin proteomics reveals novel combinatorial histone modification signatures that mark distinct subpopulations of macrophage enhancers Open
The integrated activity of cis-regulatory elements fine-tunes transcriptional programs of mammalian cells by recruiting cell type-specific as well as ubiquitous transcription factors (TFs). Despite their key role in modulating transcriptio…
View article: Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF
Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF Open
The small heat-shock protein of 27 kDa (HSP27) is highly expressed in many cancers and is associated with aggressive tumour behaviour, metastasis, poor prognosis and resistance to chemotherapy. We aimed at assessing the role of HSP27 in mo…
View article: miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth
miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth Open