Danielle Burner
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View article: MMOD-05 THE IMPACT OF EGFR VARIANTS ON INTRACRANIAL PROGRESSION FREE SURVIVAL AND OVERALL SURVIVAL IN NSCLC PATIENTS WITH BRAIN METASTASES UNDERGOING STEREOTACTIC RADIOSURGERY
MMOD-05 THE IMPACT OF EGFR VARIANTS ON INTRACRANIAL PROGRESSION FREE SURVIVAL AND OVERALL SURVIVAL IN NSCLC PATIENTS WITH BRAIN METASTASES UNDERGOING STEREOTACTIC RADIOSURGERY Open
Outcomes for patients with brain metastases (BM) from targetable epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC) have been improved with tyrosine kinase inhibitors (TKIs). However, outcomes following ster…
View article: Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate-resistant prostate cancer
Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate-resistant prostate cancer Open
To resist lineage-dependent therapies such as androgen receptor inhibition, prostate luminal epithelial adenocarcinoma cells often adopt a stem-like state resulting in lineage plasticity and phenotypic heterogeneity. Castrate-resistant pro…
View article: p53 promotes revival stem cells in the regenerating intestine after severe radiation injury
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury Open
Ionizing radiation induces cell death in the gastrointestinal (GI) epithelium by activating p53. However, p53 also prevents animal lethality caused by radiation-induced GI injury. Through single-cell RNA-sequencing of the irradiated mouse …
View article: Melanoma lymph node metastases – moving beyond quantity in clinical trial design and contemporary practice
Melanoma lymph node metastases – moving beyond quantity in clinical trial design and contemporary practice Open
The presence of lymph node metastases is a well-studied prognostic factor for cutaneous melanoma. Characterization of melanoma lymph node metastases and their association with survival in multiple, large observational studies has led to re…
View article: A novel approach to characterize phenotypic variation in GSD IV: Reconceptualizing the clinical continuum
A novel approach to characterize phenotypic variation in GSD IV: Reconceptualizing the clinical continuum Open
Purpose: Glycogen storage disease type IV (GSD IV) has historically been divided into discrete hepatic (classic hepatic, non-progressive hepatic) and neuromuscular (perinatal-congenital neuromuscular, juvenile neuromuscular) subtypes. Howe…
View article: The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer
The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer Open
Purpose To resist lineage-dependent therapies such as androgen receptor inhibition in prostate cancer, cancer cells often adopt a stem-like state resulting in lineage-plasticity and phenotypic heterogeneity. We assessed the dynamics of lin…
View article: Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids
Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids Open
Advanced prostate cancer (PCa) patients with bone metastases are treated with androgen pathway directed therapy (APDT). However, this treatment invariably fails and the cancer becomes castration resistant. To elucidate resistance mechanism…
View article: Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer
Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer Open
Background Immunotherapeutic regulation of the tumor microenvironment in prostate cancer patients is not understood. Most antibody immunotherapies have not succeeded in prostate cancer. We showed previously that high-risk PCa patients have…
View article: MP81-19 MECHANISMS OF ANTI-ANDROGEN RESISTANCE IN A 3D PATIENT-DERIVED ORGANOID MODEL OF BONE METASTATIC PROSTATE CANCER
MP81-19 MECHANISMS OF ANTI-ANDROGEN RESISTANCE IN A 3D PATIENT-DERIVED ORGANOID MODEL OF BONE METASTATIC PROSTATE CANCER Open
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology III (MP81)1 Apr 2019MP81-19 MECHANISMS OF ANTI-ANDROGEN RESISTANCE IN A 3D PATIENT-DERIVED ORGANOID MODEL OF BONE METASTATIC PROSTATE CANCER Danielle Burner…
View article: MP68-18 ENZALUTAMIDE TREATMENT RESULTS IN ANTI-ANDROGEN RESISTANCE IN PATIENT-DERIVED BONE METASTATIC PROSTATE CANCER MODELS
MP68-18 ENZALUTAMIDE TREATMENT RESULTS IN ANTI-ANDROGEN RESISTANCE IN PATIENT-DERIVED BONE METASTATIC PROSTATE CANCER MODELS Open
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II (MP68)1 Apr 2019MP68-18 ENZALUTAMIDE TREATMENT RESULTS IN ANTI-ANDROGEN RESISTANCE IN PATIENT-DERIVED BONE METASTATIC PROSTATE CANCER MODELS Christina Ja…
View article: Artificial human antigen‐presenting cells are superior to dendritic cells at inducing cytotoxic T‐cell responses
Artificial human antigen‐presenting cells are superior to dendritic cells at inducing cytotoxic T‐cell responses Open
Summary Peptide recognition through the MHC class I molecule by cytotoxic T lymphocytes ( CTL s) leads to the killing of cancer cells. A potential challenge for T‐cell immunotherapy is that dendritic cells ( DC s) are exposed to the MHC cl…
View article: MP90-06 FULL EXOME SEQUENCING, COPY NUMBER VARIATION AND TRANSCRIPTOME ANALYSES REVEALS DIVERSITY AND MUTATIONAL EVOLUTION IN A LONGITUDINAL SERIES OF SURGICAL PROSTATE CANCER BONE METASTASES FROM A PATIENT WITH PROGRESSIVELY THERAPY-RESISTANT CANCER.
MP90-06 FULL EXOME SEQUENCING, COPY NUMBER VARIATION AND TRANSCRIPTOME ANALYSES REVEALS DIVERSITY AND MUTATIONAL EVOLUTION IN A LONGITUDINAL SERIES OF SURGICAL PROSTATE CANCER BONE METASTASES FROM A PATIENT WITH PROGRESSIVELY THERAPY-RESISTANT CANCER. Open
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology IV1 Apr 2016MP90-06 FULL EXOME SEQUENCING, COPY NUMBER VARIATION AND TRANSCRIPTOME ANALYSES REVEALS DIVERSITY AND MUTATIONAL EVOLUTION IN A LONGITUDINAL SER…