Danielle C. Leander
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View article: α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion
α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion Open
α cells secrete proglucagon peptides to regulate nutrient metabolism. Recent findings support an α cell–to–β cell axis that is mediated by paracrine signaling through the glucagon receptor and glucagon-like peptide 1 (GLP-1) receptor in β …
View article: Coagulofibrinolytic effects of recombinant soluble thrombomodulin in prolonged porcine cardiac arrest
Coagulofibrinolytic effects of recombinant soluble thrombomodulin in prolonged porcine cardiac arrest Open
View article: Early or Late-Life Treatment With Acarbose or Rapamycin Improves Physical Performance and Affects Cardiac Structure in Aging Mice
Early or Late-Life Treatment With Acarbose or Rapamycin Improves Physical Performance and Affects Cardiac Structure in Aging Mice Open
Pharmacological treatments can extend the life span of mice. For optimal translation in humans, treatments should improve health during aging, and demonstrate efficacy when started later in life. Acarbose (ACA) and rapamycin (RAP) extend l…
View article: A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures
A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures Open
To date, existing animal models of the acute respiratory distress syndrome (ARDS) have failed to translate preclinical discoveries into effective pharmacotherapy or diagnostic biomarkers. To address this translational gap, we developed a h…
View article: A Novel Swine Model of the Acute Respiratory Distress Syndrome Using Clinically-Relevant Injury Exposures
A Novel Swine Model of the Acute Respiratory Distress Syndrome Using Clinically-Relevant Injury Exposures Open
To date, existing animal models of the acute respiratory distress syndrome (ARDS) have failed to translate preclinical discoveries into effective pharmacotherapy or diagnostic biomarkers. To address this translational gap, we developed a h…
View article: Aerosol generation during chest compression and defibrillation in a swine cardiac arrest model
Aerosol generation during chest compression and defibrillation in a swine cardiac arrest model Open
View article: A comprehensive assessment of multi-system responses to a renal inoculation of uropathogenic E. coli in swine
A comprehensive assessment of multi-system responses to a renal inoculation of uropathogenic E. coli in swine Open
Background The systemic responses to infection and its progression to sepsis remains poorly understood. Progress in the field has been stifled by the shortcomings of experimental models which include poor replication of the human condition…
View article: Acarbose has sex-dependent and -independent effects on age-related physical function, cardiac health, and lipid biology
Acarbose has sex-dependent and -independent effects on age-related physical function, cardiac health, and lipid biology Open
With an expanding aging population burdened with comorbidities, there is considerable interest in treatments that optimize health in later life. Acarbose (ACA), a drug used clinically to treat type 2 diabetes mellitus (T2DM), can extend mo…
View article: Dose optimization of early high-dose valproic acid for neuroprotection in a swine cardiac arrest model
Dose optimization of early high-dose valproic acid for neuroprotection in a swine cardiac arrest model Open
View article: 17‐α estradiol ameliorates age‐associated sarcopenia and improves late‐life physical function in male mice but not in females or castrated males
17‐α estradiol ameliorates age‐associated sarcopenia and improves late‐life physical function in male mice but not in females or castrated males Open
Pharmacological treatments can extend mouse lifespan, but lifespan effects often differ between sexes. 17‐α estradiol (17aE2), a less feminizing structural isomer of 17‐β estradiol, produces lifespan extension only in male mice, suggesting…
View article: Factors Affecting the Visibility of Chimpanzees (Pan troglodytes) at the Detroit Zoo
Factors Affecting the Visibility of Chimpanzees (Pan troglodytes) at the Detroit Zoo Open
Honors (Bachelor's)