Daniëlle Copmans
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View article: Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study
Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study Open
Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which…
View article: Clioquinol improves catalytic activity of PHGDH and shows antiseizure efficacy in patients
Clioquinol improves catalytic activity of PHGDH and shows antiseizure efficacy in patients Open
Drug-resistant epilepsy (DRE) affects over 25 million people worldwide and is associated with neuroinflammation. We identified haloquinolines from a drug repurposing library as potent activators of phosphoglycerate dehydrogenase (PHGDH) en…
View article: Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor
Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor Open
New pharmacological approaches that target orexin receptors (OXRs) are being developed to treat sleep disorders such as insomnia and narcolepsy, with fewer side effects than existing treatments. Orexins are neuropeptides that exert excitat…
View article: Oral Presentations
Oral Presentations Open
Purpose: Hypothalamic Hamartoma (HH) is a pharmacoresistant epileptogenic lesion. Stereotactic radiofrequency thermocoagulation (SRT) is a disconnecting intervention to treat HHs. MRI is the gold standard in unilateral HHs to determine the…
View article: From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin
From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin Open
PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the potential to treat epilepsy. In this study, we report the discovery of two new a…
View article: Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish
Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish Open
Coumarins are a well-known group of plant secondary metabolites with various pharmacological activities, including antiseizure activity. In the search for new antiseizure drugs (ASDs) to treat epilepsy, it is yet unclear which types of cou…
View article: Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish
Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish Open
Epilepsy is a common disorder of the brain characterized by spontaneous recurrent seizures, which develop gradually during a process called epileptogenesis. The mechanistic processes underlying the changes of brain tissue and networks towa…
View article: Using Zebrafish as a Disease Model to Study Fibrotic Disease
Using Zebrafish as a Disease Model to Study Fibrotic Disease Open
In drug discovery, often animal models are used that mimic human diseases as closely as possible. These animal models can be used to address various scientific questions, such as testing and evaluation of new drugs, as well as understandin…
View article: Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome
Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome Open
Flaviviruses such as the dengue (DENV) and the Zika virus (ZIKV) are important human pathogens causing around 100 million symptomatic infections each year. During infection, small subgenomic flavivirus RNAs (sfRNAs) are formed inside the i…
View article: Identification of host-factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome
Identification of host-factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome Open
Flaviviruses such as the dengue (DENV) and the Zika virus (ZIKV) are important human pathogens causing around 100 million symptomatic infections each year. During infection, small subgenomic flavivirus RNAs (sfRNAs) are formed inside the i…
View article: Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome
Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome Open
Flaviviruses such as the dengue (DENV) and the Zika virus (ZIKV) are important human pathogens causing around 100 million symptomatic infections each year. During infection, small subgenomic flavivirus RNAs (sfRNAs) are formed inside the i…
View article: Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B
Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B Open
There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the only effort to d…
View article: Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A<sub>2</sub> and Azaspirofuran A
Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A<sub>2</sub> and Azaspirofuran A Open
In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to screen marine natural products to identify promising antiseizure hits in vivo for fur…
View article: Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica Nanoparticles
Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica Nanoparticles Open
Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is being given to nanotoxicity. While silica nanoparticles (NP) are one of the top…
View article: Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine
Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine Open
Dravet syndrome (DS) is one of the most pharmacoresistant and devastating forms of childhood epilepsy syndromes. Distinct de novo mutations in the SCN1A gene are responsible for over 80% of DS cases. While DS is largely resistant to treatm…