Danielle E. Levitt
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View article: Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes
Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes Open
Background: Patients with type 2 diabetes (T2D) develop vascular complications due to arginine deficiency-induced microvascular endothelial dysfunction, which is related to the loss of muscle strength (MS) associated with aging. Thus, incr…
View article: Using Computer Vision Libraries to Streamline Nuclei Quantification
Using Computer Vision Libraries to Streamline Nuclei Quantification Open
Live cell assays and image-based cell analyses require data normalization for accurate interpretation. A commonly used method is to stain and quantify nuclei, followed by data normalization to nuclei count. This nuclei count is often expre…
View article: Passive dehydration increases oxidative stress and mTOR signalling pathway activation in young men following resistance exercise
Passive dehydration increases oxidative stress and mTOR signalling pathway activation in young men following resistance exercise Open
Dehydration is prevalent and adversely affects exercise performance; however, its influence on cellular responses to exercise remains unclear. Thus, this study examined the intramuscular responses to resistance‐exercise (RE) in RE‐trained …
View article: Resistance exercise‐induced circulating factors influence the damaged skeletal muscle proteome in a sex‐dependent manner
Resistance exercise‐induced circulating factors influence the damaged skeletal muscle proteome in a sex‐dependent manner Open
Muscle recovery after damage is mediated by circulating factors and intracellular signaling pathways. Our previous studies have demonstrated that resistance exercise (RE)‐induced circulating factors elicited sex‐differential responses in d…
View article: Red Meat Amino Acids for Beginners: A Narrative Review
Red Meat Amino Acids for Beginners: A Narrative Review Open
Meat is a major source of dietary protein and fat across the globe. Red and white meat are the major terms consumers use to refer to types of meat; however, these terms do not fully encompass the range of nutrients provided by meat sources…
View article: Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review
Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review Open
Bioenergetic pathways uniquely support sarcomere function which, in turn, helps to maintain functional skeletal muscle (SKM) mass. Emerging evidence supports alcohol (EtOH)-induced bioenergetic impairments in SKM and muscle precursor cells…
View article: High fat, high sucrose diet promotes increased expression of ACE2 receptor in the SIV-infected host: implications for SARS-CoV-2 infection
High fat, high sucrose diet promotes increased expression of ACE2 receptor in the SIV-infected host: implications for SARS-CoV-2 infection Open
Introduction People with pre-existing conditions, including metabolic comorbidities, are at greater risk for complications of SARS-CoV-2 infection and expression of machinery required for viral entry into host cells may be a contributing f…
View article: Extracellular vesicle miR-206 improves chronic binge alcohol-mediated decreased myoblast differentiation in SIV-infected female macaques
Extracellular vesicle miR-206 improves chronic binge alcohol-mediated decreased myoblast differentiation in SIV-infected female macaques Open
Alcohol decreases skeletal muscle myoblast differentiation into myotubes, which is associated with decreased expression of microRNA-206. We show that delivering exogenous miR-206 in plasma-derived extracellular vesicles (EVs) to myoblasts …
View article: Adverse Skeletal Muscle Adaptations in Individuals Born Preterm—A Comprehensive Review
Adverse Skeletal Muscle Adaptations in Individuals Born Preterm—A Comprehensive Review Open
Infants born preterm face an increased risk of deleterious effects on lung and brain health that can significantly alter long-term function and quality of life and even lead to death. Moreover, preterm birth is also associated with a heigh…
View article: Alcohol Impairs Bioenergetics and Differentiation Capacity of Myoblasts from Simian Immunodeficiency Virus-Infected Female Macaques
Alcohol Impairs Bioenergetics and Differentiation Capacity of Myoblasts from Simian Immunodeficiency Virus-Infected Female Macaques Open
Alcohol misuse and HIV independently induce myopathy. We previously showed that chronic binge alcohol (CBA) administration, with or without simian immunodeficiency virus (SIV), decreases differentiation capacity of male rhesus macaque myob…
View article: Monitoring mood state to improve performance in soccer players: A brief review
Monitoring mood state to improve performance in soccer players: A brief review Open
Introduction Psychological aspects of sport are key in maintaining athlete motivation and make a difference in competitive outcomes. Adjustments to training may be necessary according to athletes’ emotional state. Therefore, it is importan…
View article: Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review
Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review Open
Skeletal muscle mass is determined by the balance between muscle protein synthesis (MPS) and degradation. Several intracellular signaling pathways control this balance, including mammalian/mechanistic target of rapamycin (mTOR) complex 1 (…
View article: Effect of Intensified Training Camp on Psychometric Status, Mood State, and Hematological Markers in Youth Soccer Players
Effect of Intensified Training Camp on Psychometric Status, Mood State, and Hematological Markers in Youth Soccer Players Open
During training camps, training load is purposefully intensified. Intensified training loads (TL) are associated with psychological variations, increased fatigue, insufficient recovery, decreased muscular performance, and biological change…
View article: Alcohol use, physical activity, and muscle strength moderate the relationship between body composition and frailty risk among people living with <scp>HIV</scp>
Alcohol use, physical activity, and muscle strength moderate the relationship between body composition and frailty risk among people living with <span>HIV</span> Open
Background Antiretroviral therapy has improved life expectancy among people living with HIV (PLWH). Despite increased longevity, PLWH are at increased risk of age‐related comorbidities, including frailty. We examined the relationship betwe…
View article: Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells
Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells Open
CD4 + T cell differentiation to pro-inflammatory and immunosuppressive subsets depends on immunometabolism. Pro-inflammatory CD4 + subsets rely on glycolysis, while immunosuppressive Treg cells require functional mitochondria for their dif…
View article: A Practical Approach to Assessing Physical Freshness: Utility of a Simple Perceived Physical Freshness Status Scale
A Practical Approach to Assessing Physical Freshness: Utility of a Simple Perceived Physical Freshness Status Scale Open
Background: Monitoring physical freshness is essential in assessing athletes’ conditions during training periods, training sessions, or competitions. To date, no single physical freshness scale has been successfully validated against train…
View article: Sex‐specific mitochondrial dynamics and mitophagy response to muscle damage
Sex‐specific mitochondrial dynamics and mitophagy response to muscle damage Open
Muscle damage imposes stress on mitochondria resulting in mitochondrial fusion, fission, and mitophagy. Testosterone is a regulator of these processes. However, no study has examined the effect of sex‐specific resistance exercise (RE)‐indu…
View article: A review of alcohol–pathogen interactions: New insights into combined disease pathomechanisms
A review of alcohol–pathogen interactions: New insights into combined disease pathomechanisms Open
Progression of chronic infections to end‐stage diseases and poor treatment results are frequently associated with alcohol abuse. Alcohol metabolism suppresses innate and adaptive immunity leading to increased viral load and its spread. In …
View article: Unique circulating microRNA associations with dysglycemia in people living with HIV and alcohol use
Unique circulating microRNA associations with dysglycemia in people living with HIV and alcohol use Open
People living with HIV (PLWH) have increased prevalence of comorbid conditions including insulin resistance and at-risk alcohol use. Circulating microRNAs (miRs) may serve as minimally invasive indicators of pathophysiological states. We a…
View article: Differential Autophagy Response in Men and Women After Muscle Damage
Differential Autophagy Response in Men and Women After Muscle Damage Open
Following muscle damage, autophagy is crucial for muscle regeneration. Hormones (e.g., testosterone, cortisol) regulate this process and sex differences in autophagic flux exist in the basal state. However, to date, no study has examined t…
View article: Skeletal muscle bioenergetic health and function in people living with HIV: association with glucose tolerance and alcohol use
Skeletal muscle bioenergetic health and function in people living with HIV: association with glucose tolerance and alcohol use Open
At-risk alcohol use is prevalent and increases dysglycemia among people living with human immunodeficiency virus (PLWH). Skeletal muscle (SKM) bioenergetic dysregulation is implicated in dysglycemia and type 2 diabetes. The objective of th…
View article: Chronic binge alcohol and ovariectomy-mediated impaired insulin responsiveness in SIV-infected female rhesus macaques
Chronic binge alcohol and ovariectomy-mediated impaired insulin responsiveness in SIV-infected female rhesus macaques Open
Aging people living with HIV (PLWH), especially postmenopausal women may be at higher risk of comorbidities associated with HIV, antiretroviral therapy (ART), hypogonadism, and at-risk alcohol use. Our studies in simian immunodeficiency vi…
View article: Alcohol use and dysglycemia among people living with human immunodeficiency virus (HIV) in the Alcohol & Metabolic Comorbidities in PLWH: Evidence Driven Interventions (ALIVE‐Ex) study
Alcohol use and dysglycemia among people living with human immunodeficiency virus (HIV) in the Alcohol & Metabolic Comorbidities in PLWH: Evidence Driven Interventions (ALIVE‐Ex) study Open
Background At‐risk alcohol use is a common and costly form of substance misuse that is highly prevalent among people living with HIV (PLWH). The goal of the current analysis was to test the hypothesis that PLWH with at‐risk alcohol use are…
View article: Pathophysiological mechanisms of alcoholic myopathy - Lessons from rodent models
Pathophysiological mechanisms of alcoholic myopathy - Lessons from rodent models Open
Skeletal muscle dysfunction is highly prevalent and is one of the earliest pathological tissue changes among people with at-risk alcohol use. Clinical studies to elucidate pathophysiological mechanisms of alcohol-mediated muscle disease ar…
View article: Training, psychometric status, biological markers and neuromuscular fatigue in soccer
Training, psychometric status, biological markers and neuromuscular fatigue in soccer Open
The study examined the relationship between psychometric status, neuromuscular, and biochemical markers of fatigue in response to an intensified training (IT) period in soccer. Fifteen professional soccer players volunteered to participate…
View article: High‐Fat High‐Sucrose Diet Increases ACE2 Receptor Expression in Lung and Pancreatic Islets in SIV‐Infected Rhesus Macaques: Implications for Increased Risk for SARS‐CoV‐2 Infection
High‐Fat High‐Sucrose Diet Increases ACE2 Receptor Expression in Lung and Pancreatic Islets in SIV‐Infected Rhesus Macaques: Implications for Increased Risk for SARS‐CoV‐2 Infection Open
People with pre‐existing conditions including obesity, diabetes, and kidney disease are at greater risk for complications of COVID‐19, the disease caused by SARS‐CoV‐2 infection. Predisposing risk factors could include poor dietary quality…
View article: Relationship between Perceived Training Load, Well-Being Indices, Recovery State and Physical Enjoyment during Judo-Specific Training
Relationship between Perceived Training Load, Well-Being Indices, Recovery State and Physical Enjoyment during Judo-Specific Training Open
This study investigated the relationship between well-being indices and the session rating of perceived exertion (session-RPE), recovery (TQR), and physical enjoyment (PE) during intensified, tapering phases of judo training. Sixty-one jud…
View article: Ethanol‐Impaired Myogenic Differentiation is Associated With Decreased Myoblast Glycolytic Function
Ethanol‐Impaired Myogenic Differentiation is Associated With Decreased Myoblast Glycolytic Function Open
Background Myopathy affects nearly half of individuals with alcohol use disorder (AUD), and impaired skeletal muscle regenerative potential is a probable contributing factor. Previous findings from our laboratory indicate that chronic in v…