Danielle Labbato
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View article: Evaluation of Interventions for Cognitive Symptoms in Long COVID
Evaluation of Interventions for Cognitive Symptoms in Long COVID Open
Importance Treatment for cognitive dysfunction due to postacute sequelae of long COVID (ie, symptoms of fatigue, malaise, weakness, confusion that persist beyond 12 weeks after an initial COVID infection) remains a significant unmet need. …
View article: Semaglutide Slows Epigenetic Aging in People with HIV-associated lipohypertrophy: Evidence from a Randomized Controlled Trial
Semaglutide Slows Epigenetic Aging in People with HIV-associated lipohypertrophy: Evidence from a Randomized Controlled Trial Open
Semaglutide is a once-weekly GLP-1 receptor agonist that has been proposed as a gerotherapeutic, yet no data exist on its effects on epigenetic aging. We therefore conducted a post-hoc epigenetic analysis of a 32-week, double-blind, placeb…
View article: Zinc Supplementation, Inflammation, and Gut Integrity Markers in HIV Infection: A Randomized Placebo-Controlled Trial
Zinc Supplementation, Inflammation, and Gut Integrity Markers in HIV Infection: A Randomized Placebo-Controlled Trial Open
Background: Low levels of zinc are prevalent in patients living with HIV and are associated with higher morbidity. Zinc has major immunomodulatory effects. This study aimed to assess the effect of zinc supplementation on inflammatory and g…
View article: The Effects of Semaglutide on Inflammation and Immune Activation in HIV-associated Lipohypertrophy
The Effects of Semaglutide on Inflammation and Immune Activation in HIV-associated Lipohypertrophy Open
Background Cardiovascular and metabolic comorbidities are common in people with HIV (PWH) and are linked to chronic inflammation and immune activation. We assessed the effects of semaglutide on plasma markers of immune activation/inflammat…
View article: The Effect of COVID-19 on Arterial Stiffness and Inflammation: A Longitudinal Prospective Study
The Effect of COVID-19 on Arterial Stiffness and Inflammation: A Longitudinal Prospective Study Open
Data are limited for assessing the effect of COVID infection on endothelial function, pre- and post-pandemic. The objective of this study was to assess changes in pre-pandemic cardiovascular parameters after COVID-19 infection. This prospe…
View article: Vitamins K2 and D3 Improve Long COVID, Fungal Translocation, and Inflammation: Randomized Controlled Trial
Vitamins K2 and D3 Improve Long COVID, Fungal Translocation, and Inflammation: Randomized Controlled Trial Open
Background: Long COVID (LC) is characterized by persistent symptoms at least 3 months after a SARS-COV-2 infection. LC has been associated with fungal translocation, gut dysfunction, and enhanced systemic inflammation. Currently, there is …
View article: Associations of Plasma Erythritol with Dietary Factors, Cardiometabolic, Inflammatory, and Gut Health Markers in People with and without HIV: A Cross-Sectional Study
Associations of Plasma Erythritol with Dietary Factors, Cardiometabolic, Inflammatory, and Gut Health Markers in People with and without HIV: A Cross-Sectional Study Open
Background: Recently, elevated levels of plasma erythritol have been associated with major adverse cardiovascular events (MACE). It is known that people with HIV (PWH) have a higher cardiovascular disease burden. Whether PWH have higher le…
View article: Sex Modifies the Effect of COVID-19 on Arterial Elasticity
Sex Modifies the Effect of COVID-19 on Arterial Elasticity Open
There is limited long-term evidence on the effects of COVID-19 on vascular injury between male and female sex. An adult cohort of COVID-19 survivors (COVID+) and confirmed SARS-CoV-2 antibody-negative participants (COVID-) were prospective…
View article: The Long-Term Effect of COVID-19 Infection on Body Composition
The Long-Term Effect of COVID-19 Infection on Body Composition Open
Background: The effect of COVID-19 infection versus the indirect effect of the pandemic on body composition remains unclear. This study investigates the long-term changes in body composition in COVID-19 survivors compared to a contemporary…
View article: The Long-Term Effect of COVID-19 Infection on Body Composition
The Long-Term Effect of COVID-19 Infection on Body Composition Open
Background: The effect of COVID-19 infection, versus the indirect effect of the pandemic on body composition remains unclear. This study investigates long-term changes in body composition in COVID–19 survivors compared to a contemporary co…
View article: Arterial Stiffness and Oxidized LDL Independently Associated With Post-Acute Sequalae of SARS-CoV-2
Arterial Stiffness and Oxidized LDL Independently Associated With Post-Acute Sequalae of SARS-CoV-2 Open
OBJECTIVE: COVID-19 survivors can experience lingering symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) that appear in different phenotypes, and its etiology remains elusive. We assessed the relationship of endothelial dysfunctio…
View article: 1984. Effects of Semaglutide on Adipose Tissue in HIV-Associated Lipohypertrophy
1984. Effects of Semaglutide on Adipose Tissue in HIV-Associated Lipohypertrophy Open
Background Lipohypertrophy (central adipose tissue (AT) accumulation) is a common and significant problem in people with HIV (PWH). Pathogenesis remains elusive; yet, AT abnormalities are key drivers of cardiometabolic co-morbidities in HI…
View article: Increase in gut permeability and oxidized ldl is associated with post-acute sequelae of SARS-CoV-2
Increase in gut permeability and oxidized ldl is associated with post-acute sequelae of SARS-CoV-2 Open
Background Post-acute sequelae of SARS-CoV-2 (PASC) is marked by persistent or newly developing symptoms beyond 4 weeks of infection. Investigating gut integrity, oxidized lipids and inflammatory markers is important for understanding PASC…
View article: Longitudinal Changes in Subclinical Vascular Disease in Ugandan Youth With Human Immunodeficiency Virus
Longitudinal Changes in Subclinical Vascular Disease in Ugandan Youth With Human Immunodeficiency Virus Open
Background Prospective investigations on the risk of cardiovascular disease among youth with perinatally acquired human immunodeficiency virus (PHIV) in sub-Saharan Africa are lacking. Methods A prospective observational cohort study was p…
View article: Effects of vitamin D supplementation on carotid intima-media thickness in HIV-infected youth
Effects of vitamin D supplementation on carotid intima-media thickness in HIV-infected youth Open
Effects of vitamin D supplementation on carotid intima-media thickness in HIV-infected youth
View article: Vitamin K & D Deficiencies Are Independently Associated With COVID-19 Disease Severity
Vitamin K & D Deficiencies Are Independently Associated With COVID-19 Disease Severity Open
Background We investigated the association of vitamin K and vitamin D with coronavirus disease 2019 (COVID-19) outcomes. Methods Levels of inactive vitamin K–dependent dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP; marker of…
View article: Fecal Calprotectin Is Elevated in HIV and Related to Systemic Inflammation
Fecal Calprotectin Is Elevated in HIV and Related to Systemic Inflammation Open
Background: Fecal calprotectin (FC), a biomarker of gastrointestinal (GI) inflammation, is used in the diagnosis and management of inflammatory bowel disease. HIV infection severely damages gut-associated lymphoid and epithelial tissues le…
View article: Increased monocyte and T-cell activation in treated HIV+ Ugandan children: associations with gut alteration and HIV factors
Increased monocyte and T-cell activation in treated HIV+ Ugandan children: associations with gut alteration and HIV factors Open
Introduction: The pathophysiology of immune activation and its mechanisms in children living with perinatally acquired HIV (PHIV) in sub-Saharan Africa has been understudied. Methods: We enrolled 101 children living with PHIV and 96 HIV-ne…
View article: Fibroblast Growth Factor 21 Is Elevated in HIV and Associated With Interleukin-6
Fibroblast Growth Factor 21 Is Elevated in HIV and Associated With Interleukin-6 Open
To the Editors: Fibroblast growth factor 21 (FGF21) is a circulating peptide hormone primarily synthesized by the liver, and to a lesser extent, by skeletal muscle, adipose tissue, and pancreas.1,2 Its physiology is complex, given its dive…
View article: Subclinical Vascular Disease in Children With Human Immunodeficiency Virus in Uganda Is Associated With Intestinal Barrier Dysfunction
Subclinical Vascular Disease in Children With Human Immunodeficiency Virus in Uganda Is Associated With Intestinal Barrier Dysfunction Open
Background The risk of cardiovascular disease (CVD) and its mechanisms in children living with perinatally acquired HIV (PHIV) in sub-Saharan Africa has been understudied. Methods Mean common carotid artery intima-media thickness (IMT) and…
View article: Effects of Vitamin D Supplementation on Bone Mineral Density and Bone Markers in HIV-Infected Youth
Effects of Vitamin D Supplementation on Bone Mineral Density and Bone Markers in HIV-Infected Youth Open
Background: Low bone mineral density (BMD) is a significant comorbidity in HIV. However, studies evaluating vitamin D supplementation on bone health in this population are limited. This study investigates changes in bone health parameters …
View article: Effects of vitamin D supplementation on carotid intima-media thickness in HIV-infected youth
Effects of vitamin D supplementation on carotid intima-media thickness in HIV-infected youth Open
KEYWORDS: cardiovascular diseasecarotid intima-media thicknessHIVpediatrics and adolescentsrandomized-controlled trialvitamin D
View article: Vitamin D Supplementation Decreases Immune Activation and Exhaustion in HIV-1-Infected Youth
Vitamin D Supplementation Decreases Immune Activation and Exhaustion in HIV-1-Infected Youth Open
Background Heightened immune activation and exhaustion drive HIV disease progression and comorbidities. Vitamin D has pleiotropic immunomodulatory effects, but little is known about the effects of supplementation in HIV. Our study investig…
View article: Arterial stiffness in HIV-infected youth and associations with HIV-related variables
Arterial stiffness in HIV-infected youth and associations with HIV-related variables Open
Children and young adults infected with HIV are at elevated risk for cardiovascular disease (CVD). However, scarce data exist on the utility of non-invasive methods to diagnose subclinical CVD, such as pulse wave velocity (PWV), a non-inva…
View article: Alcohol and dietary factors associate with gut integrity and inflammation in <scp>HIV</scp>‐infected adults
Alcohol and dietary factors associate with gut integrity and inflammation in <span>HIV</span>‐infected adults Open
Objectives HIV ‐infected adults have heightened monocyte activation and inflammation, at least partially as a consequence of altered gut integrity. The role of dietary factors in microbial translocation and inflammation and their downstrea…
View article: Increased Immune Activation and Exhaustion in HIV-infected Youth
Increased Immune Activation and Exhaustion in HIV-infected Youth Open
CD4+ and CD8+ T-cell immune activation and exhaustion are higher in HIV-infected youth compared with matched controls, while monocyte subpopulations are not altered despite a high soluble CD14 level. The clinical significance of the increa…