Danielle M. Clancy
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View article: Themis and Grb2 form a constitutive structural hub in T cell receptor signalling
Themis and Grb2 form a constitutive structural hub in T cell receptor signalling Open
Positive selection of thymocytes is essential for laying the foundations of the mammalian immune system that include the T cell repertoire, self-tolerance, and prevention of autoimmunity. Themis, the archetypal member of a metazoan protein…
View article: Structural basis of pro-inflammatory signaling via the Interleukin-36 receptor (IL-36R) mediated by IL-36γ and IL-37
Structural basis of pro-inflammatory signaling via the Interleukin-36 receptor (IL-36R) mediated by IL-36γ and IL-37 Open
Interleukin-36 receptor (IL-36R) is activated by IL-36α, IL-36β, and IL-36γ to elicit pro-inflammatory signaling and is targeted in acute skin inflammation by the approved antibody spesolimab. IL-37 was recently proposed as a new IL-36R ag…
View article: Themis and Grb2 form a constitutive structural hub in T cell receptor signalling
Themis and Grb2 form a constitutive structural hub in T cell receptor signalling Open
Positive selection of thymocytes is essential for laying the foundations of the mammalian immune system that include the T cell repertoire, self-tolerance, and prevention of autoimmunity. Themis, the archetypal member of a metazoan protein…
View article: Myeloid cell–derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
Myeloid cell–derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement Open
Interleukin-1 (IL-1) family cytokines are key barrier cytokines that are typically expressed as inactive, or partially active, precursors that require proteolysis within their amino termini for activation. IL-37 is an enigmatic member of t…
View article: IL-1 family cytokines serve as 'activity recognition receptors' for aberrant protease activity indicative of danger
IL-1 family cytokines serve as 'activity recognition receptors' for aberrant protease activity indicative of danger Open
Members of the extended IL-1 cytokine family play key roles as instigators of inflammation in numerous infectious and sterile injury contexts and are highly enriched at barrier surfaces such as the skin, lungs and intestinal mucosa. Becaus…
View article: Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity
Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity Open
Human Interleukin-18 (IL-18) is an omnipresent proinflammatory cytokine of the IL-1 family with central roles in autoimmune and inflammatory diseases and serves as a staple biomarker in the evaluation of inflammation in physiology and dise…
View article: Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein (IL-18BP) in inflammation and tumor immunity
Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein (IL-18BP) in inflammation and tumor immunity Open
Human Interleukin-18 (IL-18) is an omnipresent pro-inflammatory cytokine of the IL-1 family with central roles in autoimmune and inflammatory diseases, and serving as a staple biomarker in the evaluation of inflammation in physiology and d…
View article: iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE Open
The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves TNF from its tr…
View article: Author response: iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
Author response: iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The apical inflammatory cytok…
View article: Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing
Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing Open
Neutrophil granule proteases are thought to function as anti-microbial effectors, cooperatively hydrolyzing microorganisms within phagosomes, or upon deployment into the extracellular space. However, evidence also suggests that neutrophil …
View article: Identification of small‐molecule elastase inhibitors as antagonists of IL‐36 cytokine activation
Identification of small‐molecule elastase inhibitors as antagonists of IL‐36 cytokine activation Open
IL‐1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL‐36α, IL‐36β and IL…
View article: iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE Open
The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires ADAM17/TACE, which cleaves TNF from its transmembrane te…
View article: Neutrophil extracellular traps can serve as platforms for processing and activation of <scp>IL</scp>‐1 family cytokines
Neutrophil extracellular traps can serve as platforms for processing and activation of <span>IL</span>‐1 family cytokines Open
Activated neutrophils can undergo a mode of regulated cell death, called NET osis, that results in the extrusion of chromatin into the extracellular space, thereby acting as extracellular traps for microorganisms. Neutrophil‐derived extrac…
View article: Production of biologically active IL‐36 family cytokines through insertion of N‐terminal caspase cleavage motifs
Production of biologically active IL‐36 family cytokines through insertion of N‐terminal caspase cleavage motifs Open
Recent evidence has strongly implicated IL‐36 cytokines as key initiators of inflammation in the skin barrier. IL‐36 cytokines belong to the extended IL‐1 family and, similar to most members of this family, are expressed as inactive precur…
View article: Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines Open
Recent evidence has strongly implicated the IL-1 family cytokines IL-36α, IL-36β, and IL-36γ as key initiators of skin inflammation. Similar to the other members of the IL-1 family, IL-36 cytokines are expressed as inactive precursors and …