Explanipedia

Role of Rubicon in Platelets: A Promoter of Thrombosis but Not an Autophagy Repressor Open

Hammodah R. Alfar, Elizabeth R. Driehaus, Daniëlle M. Coenen · 2025

Rubicon (RUN domain Beclin-1-interacting and cysteine-rich-containing protein) is a negative regulator of autophagy in nucleated cells; however, its role in platelets is unstudied. Here, we identify an autophagy-independent role for Rubico…

Immuno‐haemostatic dysregulation in heart failure with preserved ejection fraction Open

Giorgia D’Italia, Daniëlle M. Coenen, T.P. Lemmens, Lloyd Brandts, Simone Wielders , et al. · 2025

Aims Heart failure with preserved ejection fraction (HFpEF) is a complex condition with partially unclear pathophysiology, in which systemic inflammation is a central contributor to changes in cardiac structure and function. The contributi…

Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets Open

A.D. Smith, Hammodah R. Alfar, Smita Joshi, Daniëlle M. Coenen, Joshua Lykins , et al. · 2025

Platelets modulate vascular microenvironments via the release of cargo molecules. Granule secretion is modulated by proteins called soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs). Secretion is complex and r…

Platelet endocytosis and α-granule cargo packaging are essential for normal skin wound healing Open

Daniëlle M. Coenen, Hammodah R. Alfar, Sidney W. Whiteheart · 2025

The high prevalence of chronic wounds, i.e., 2.5-3% of the US population, causes a large social and financial burden. Physiological wound healing is a multi-step process that involves different cell types and growth factors. Platelet-rich …

Unfolded von Willebrand factor binds protein S and reduces anticoagulant activity Open

Martha M.S. Sim, Molly Y. Mollica, Hammodah R. Alfar, Melissa Hollifield, Dominic W. Chung , et al. · 2024

Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity Open

Martha M.S. Sim, Molly Y. Mollica, Hammodah R. Alfar, Melissa Hollifield, Dominic W. Chung , et al. · 2024

Protein S (PS), the critical plasma cofactor for the anticoagulants tissue factor (TF) pathway inhibitor (TFPI) and activated protein C (APC), circulates in two functionally distinct pools: free (anticoagulant) or bound to complement compo…

PB0864 Platelet Secretion in Wound Healing: The Essence of α-granule Endocytosis, Biogenesis, and Release Kinetics Open

Daniëlle M. Coenen, Sidney W. Whiteheart · 2023

Background: Wound healing is a multi-step process involving different cell types and growth factors.Though platelet-rich plasma has been used to accelerate wound repair, functional understanding of how platelet functions affect wound heali…

OC 18.3 Platelet Mitochondrial Bioenergetics is Critical for Clot Contraction, Hemostasis and Thrombosis Open

Kanakanagavalli Shravani Prakhya, Hemendra J. Vekaria, Joseph Lykins, Daniëlle M. Coenen, Smita Joshi , et al. · 2023

PB0870 The Role of Cysteine String Protein-α in Platelet Exocytosis Open

Alexis Nicole Smith, Linda Omali, Daniëlle M. Coenen, Smita Joshi, Sidney W. Whiteheart · 2023

PB1402 NBEAL2 and the Intragranular Proteoglycan, Serglycin, Both Contribute to the Initiation and Progression of Aortic Aneurysms Open

Daniëlle M. Coenen, Sidney W. Whiteheart · 2023

Protocol for optimizing production and quality control of infective EcoHIV virions Open

Hammodah R. Alfar, Daphne N. Pariser, Harry Chanzu, Smita Joshi, Daniëlle M. Coenen , et al. · 2023

EcoHIV is a model of HIV infection that recapitulates aspects of HIV-1 pathology in mice. However, there are limited published protocols to guide EcoHIV virion production. Here, we present a protocol for producing infective EcoHIV virions …

Finding the “switch” in platelet activation: prediction of key mediators involved in reversal of platelet activation using a novel network biology approach Open

T.P. Lemmens, Daniëlle M. Coenen, Frauke Swieringa, I.C.L. Niessen, Susan L. Coort , et al. · 2022

Combined Antiplatelet Therapy Reduces the Proinflammatory Properties of Activated Platelets Open

Alexandra C.A. Heinzmann, Daniëlle M. Coenen, Tanja Vajen, Judith M.E.M. Cosemans, Rory R. Koenen · 2021

The cause of atherothrombosis is rupture or erosion of atherosclerotic lesions, leading to an increased risk of myocardial infarction or stroke. Here, platelet activation plays a major role, leading to the release of bioactive molecules, f…

Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions Open

Daniëlle M. Coenen, Alexandra C.A. Heinzmann, Silvia Oggero, Hugo J. Albers, Magdolna Nagy , et al. · 2021

Objective: platelets possess not only haemostatic but also inflammatory properties, which combined are thought to play a detrimental role in thromboinflammatory diseases such as acute coronary syndromes and stroke. Phosphodiesterase (PDE) …

The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events Open

Daniëlle M. Coenen, Alexandra C.A. Heinzmann, Mieke F.A. Karel, Judith M.E.M. Cosemans, Rory R. Koenen · 2021

Unraveling platelet function in inflammation and thrombosis Open

Daniëlle M. Coenen · 2021

Traditionally, in vitro flow chamber experiments and in vivo arterial thrombosis studies have been proved to be of vital importance to elucidate the mechanisms of platelet thrombus formation after vessel wall injury.In recent years, it has…

Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery Open

Tom G. Mastenbroek, Mieke F.A. Karel, Magdolna Nagy, Walid Chayouâ, Evelien Korsten , et al. · 2020

Complementary roles of platelet αIIbβ3 integrin, phosphatidylserine exposure and cytoskeletal rearrangement in the release of extracellular vesicles Open

Alexandra C.A. Heinzmann, Mieke F.A. Karel, Daniëlle M. Coenen, Tanja Vajen, Nicole Meulendijks , et al. · 2020

SLC44A2 deficient mice have a reduced response in stenosis but not in hypercoagulability driven venous thrombosis Open

Julia Tilburg, Daniëlle M. Coenen, Gaïa Zirka, Sophie Dólleman, Annemarie M. van Oeveren‐Rietdijk , et al. · 2020

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis Open

Elisa D’Alessandro, Christian Becker, Wolfgang Bergmeier, Christoph Bode, Joshua H. Bourne , et al. · 2020

Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, …

Correction to: Manifesting heterozygotes in McArdle disease: a myth or a reality‐role of statins Open

Judit Núñez‐Manchón, Alfonsina Ballester‐Lopez, Emma Koehorst, Ian Linares‐Pardo, Daniëlle M. Coenen , et al. · 2018

Unfortunately the name of one of the authors was spelled incorrectly in the published original article. The correct name is Alejandro Santos‐Lozano. The original article got updated.

Manifesting heterozygotes in McArdle disease: a myth or a reality—role of statins Open

Judit Núñez‐Manchón, Alfonsina Ballester‐Lopez, Emma Koehorst, Ian Linares‐Pardo, Daniëlle M. Coenen , et al. · 2018

McArdle disease is an autosomal recessive condition caused by deficiency of the PYGM gene‐encoded muscle isoform of glycogen phosphorylase. Some cases of “manifesting” heterozygotes or carriers (i.e., patients who show some McArdle‐like sy…

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis Open

Henri M.H. Spronk, Teresa Padró, Joylene E. Siland, Jürgen H. Prochaska, Joris Winters , et al. · 2018

Atherothrombosis is a leading cause of cardiovascular mortality and long-term morbidity. Platelets and coagulation proteases, interacting with circulating cells and in different vascular beds, modify several complex pathologies including a…

Platelet interaction with activated endothelium: mechanistic insights from microfluidics Open

Daniëlle M. Coenen, Tom G. Mastenbroek, Judith M.E.M. Cosemans · 2017

Traditionally, in vitro flow chamber experiments and in vivo arterial thrombosis studies have been proved to be of vital importance to elucidate the mechanisms of platelet thrombus formation after vessel wall injury. In recent years, it ha…

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells Open

Gisela Nogales‐Gadea, Abhishek Saxena, Carolin Hoffmann, Judith Hounjet, Daniëlle M. Coenen , et al. · 2015

Finding new methods for generating human monoclonal antibodies is an active research field that is important for both basic and applied sciences, including the development of immunotherapeutics. However, the techniques to identify and prod…

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