Danielle R. Reed
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View article: Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism
Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism Open
Type 2 cytokine release promotes wound healing and helminth clearance, but it remains unclear whether group 2 innate lymphocytes (ILC2s) and T-helper 2 cells (T H 2) cells have functionally distinct roles during anamnestic immunity. This s…
View article: Human olfactory organoids as an <i>in vitro</i> model of the olfactory epithelium
Human olfactory organoids as an <i>in vitro</i> model of the olfactory epithelium Open
/Key Points A novel human olfactory epithelial organoid model has been generated from primary cell culture. Human olfactory organoids exhibit immunostaining and gene expression for olfactory cells. Olfactory organoids mobilize Ca 2+ in res…
View article: 0941 Disulfiram induces immunogenic cell death in merkel cell carcinoma
0941 Disulfiram induces immunogenic cell death in merkel cell carcinoma Open
View article: Ambient Air Pollution and Smell Function: Evidence from the National Geographic Smell Survey
Ambient Air Pollution and Smell Function: Evidence from the National Geographic Smell Survey Open
Background Olfactory sensory neurons are located outside the brain, allowing them to detect environmental chemicals. However, this comes at the cost of exposure to potential toxins, which may decrease olfactory function. Methods We sought …
View article: Using nonsynonymous mutations in taste and olfactory receptor genes to investigate the influence of eating behaviour on health
Using nonsynonymous mutations in taste and olfactory receptor genes to investigate the influence of eating behaviour on health Open
Genome-wide association studies (GWAS) of food preferences (1) and intake (2) have identified hundreds of loci, most previously linked to health conditions. This suggests these loci may reflect participants’ health status, leaving unclear …
View article: Diagnosis of Primary Trimethylaminuria in an Affected Patient With a Rare Genotype in Sub‐Saharan Africa
Diagnosis of Primary Trimethylaminuria in an Affected Patient With a Rare Genotype in Sub‐Saharan Africa Open
Primary trimethylaminuria (TMAU) is characterized by systemic accumulation of trimethylamine (TMA) due to the deficient activity of flavin‐containing monooxygenase 3 (FMO3). The disorder does not have detrimental pathophysiological consequ…
View article: MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33
MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33 Open
View article: Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics
Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics Open
The Key research and development program of Shandong Province (2021LCZX07), Natural Science Foundation of Shandong Province (ZR2023MH046), Youth Science Foundation Cultivation Funding Plan of Shandong First Medical University (Shandong Aca…
View article: Understanding the determinants of sweet taste liking in the African and East Asian ancestry groups in the U.S.–A study protocol
Understanding the determinants of sweet taste liking in the African and East Asian ancestry groups in the U.S.–A study protocol Open
Background The liking for sweet taste is a powerful driver for consuming added sugars, and therefore, understanding how sweet liking is formed is a critical step in devising strategies to lower added sugars consumption. However, current re…
View article: Pan-cancer and single-cell analyses reveal LAMP3 as a biomarker associated with cancer prognosis and immune infiltration
Pan-cancer and single-cell analyses reveal LAMP3 as a biomarker associated with cancer prognosis and immune infiltration Open
Background: Lysosomal-associated membrane protein 3 (LAMP3) is a member of the LAMP family and is also known as a marker of mature dendritic cells (DCs). However, it is unclear how the expression of LAMP3 is linked to human cancers or immu…
View article: Worldwide study of the taste of bitter medicines and their modifiers
Worldwide study of the taste of bitter medicines and their modifiers Open
The bitter taste of medicines hinders patient compliance, but not everyone experiences these difficulties because people worldwide differ in their bitterness perception. To better understand how people from diverse ancestries perceive medi…
View article: Using SCENTinel® to predict SARS-CoV-2 infection: insights from a community sample during dominance of Delta and Omicron variants
Using SCENTinel® to predict SARS-CoV-2 infection: insights from a community sample during dominance of Delta and Omicron variants Open
Introduction Based on a large body of previous research suggesting that smell loss was a predictor of COVID-19, we investigated the ability of SCENTinel®, a newly validated rapid olfactory test that assesses odor detection, intensity, and …
View article: Hi-C, a chromatin 3D structure technique advancing the functional genomics of immune cells
Hi-C, a chromatin 3D structure technique advancing the functional genomics of immune cells Open
The functional performance of immune cells relies on a complex transcriptional regulatory network. The three-dimensional structure of chromatin can affect chromatin status and gene expression patterns, and plays an important regulatory rol…
View article: Single-cell RNA-seq reveals keratinocyte and fibroblast heterogeneity and their crosstalk via epithelial-mesenchymal transition in psoriasis
Single-cell RNA-seq reveals keratinocyte and fibroblast heterogeneity and their crosstalk via epithelial-mesenchymal transition in psoriasis Open
View article: A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection
A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection Open
View article: Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide
Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide Open
Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear. Here, we reveal a new mechanism used by glioma cells to modul…
View article: Single-Cell Multiomic Analysis Revealed the Transcriptional and Epigenetic Regulatory Characteristics of Esophageal Squamous Cell Carcinoma
Single-Cell Multiomic Analysis Revealed the Transcriptional and Epigenetic Regulatory Characteristics of Esophageal Squamous Cell Carcinoma Open
View article: MrgprA3 neurons selectively control myeloid-derived cytokines for IL-17 dependent cutaneous immunity.
MrgprA3 neurons selectively control myeloid-derived cytokines for IL-17 dependent cutaneous immunity. Open
View article: Understanding the Determinants of Sweet Liking in the African and East Asian Ancestry Groups in the U.S. – A Study Protocol
Understanding the Determinants of Sweet Liking in the African and East Asian Ancestry Groups in the U.S. – A Study Protocol Open
Background The liking for sweet taste is a powerful driver for consuming added sugars, and therefore, understanding how sweet liking is formed is a critical step in devising strategies to lower added sugars consumption. However, current re…
View article: Direct measures of liking and intensity of taste, smell, and chemesthetic stimuli are similar between young people reporting they did or did not have COVID-19
Direct measures of liking and intensity of taste, smell, and chemesthetic stimuli are similar between young people reporting they did or did not have COVID-19 Open
The recovery period from post-COVID-19 smell and taste dysfunctions varies substantially, lasting from a few days to over a year. We aimed to assess the impact of COVID-19 on post-COVID-19 chemosensory sensitivity in a group of young conva…
View article: Thiazolidinediones are partially effective bitter blockers
Thiazolidinediones are partially effective bitter blockers Open
Purpose The bad bitter taste of some medicines is a barrier to overcoming non-compliance with medication use, especially life-saving drugs given to children and the elderly. Here we evaluated a new class of bitter blockers (thiazolidinedio…
View article: Acute Taste Dysfunction in Oropharyngeal Cancer Patients after Transoral Robotic Surgery
Acute Taste Dysfunction in Oropharyngeal Cancer Patients after Transoral Robotic Surgery Open
Objectives To compare taste changes after transoral robotic surgery (TORS) to taste changes in healthy controls. Methods Oropharyngeal cancer patients receiving TORS and healthy controls were recruited. Participants underwent posterolatera…
View article: Single-cell RNA-seq reveals keratinocytes and fibroblasts heterogeneity and their crosstalk via epithelial-mesenchymal transition in psoriasis
Single-cell RNA-seq reveals keratinocytes and fibroblasts heterogeneity and their crosstalk via epithelial-mesenchymal transition in psoriasis Open
As a chronic inflammatory autoimmune skin disease with high global prevalence, the pathogenesis of psoriasis remains inconclusive. We performed a high-resolution single-cell RNA sequencing analysis of 94 759 cells from 13 samples including…
View article: Low to moderate genetic influences on the rapid smell test SCENTinel™
Low to moderate genetic influences on the rapid smell test SCENTinel™ Open
SCENTinel ™ - a rapid, inexpensive smell test that measures odor detection, intensity, identification, and pleasantness - was developed for population-wide screening of smell function. SCENTinel ™ was previously found to screen for multipl…
View article: Lipopolysaccharide increases bitter taste sensitivity via epigenetic changes in Tas2r gene clusters
Lipopolysaccharide increases bitter taste sensitivity via epigenetic changes in Tas2r gene clusters Open
T2R bitter receptors, encoded by Tas2r genes, are not only critical for bitter taste signal transduction but also important for defense against bacteria and parasites. However, little is known about whether and how Tas2r gene…
View article: Inflammation induces bitter taste oversensitization via epigenetic changes in<i>Tas2r</i>gene clusters
Inflammation induces bitter taste oversensitization via epigenetic changes in<i>Tas2r</i>gene clusters Open
Summary T2R bitter receptors, encoded by Tas2r genes, are not only critical for bitter taste signal transduction but also important for defense against bacteria and parasites. However, little is known about whether and how Tas2r gene expre…
View article: Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders
Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders Open
It is estimated that 20%–67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for olfactory disorders. The purpose of …
View article: Abstract 2323: Mutagenizing the bacterial small protein AcrZ and observing its effects on antibiotic resistance in E. coli
Abstract 2323: Mutagenizing the bacterial small protein AcrZ and observing its effects on antibiotic resistance in E. coli Open
View article: Reply: taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis
Reply: taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis Open
Journal Article Reply: taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis Get access Mackenzie E Hannum, Mackenzie E Hannum Monell Chemical Senses Center, 3500 Market St, Philadelphia PA 19104, United State…
View article: Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis
Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis Open
Chemosensory scientists have been skeptical that reports of COVID-19 taste loss are genuine, in part because before COVID-19 taste loss was rare and often confused with smell loss. Therefore, to establish the predicted prevalence rate of t…