Kylie D. Rock
YOU?
Author Swipe
View article: Toxicological, Chemical, Social, and Economic Challenges Associated with PFAS and Replacement Aqueous Film-Forming Foams (AFFF)
Toxicological, Chemical, Social, and Economic Challenges Associated with PFAS and Replacement Aqueous Film-Forming Foams (AFFF) Open
Poly- and perfluorinated alkyl substances (PFAS) are a group of chemicals that are widely used, prevalent in the environment, associated with several toxic effects, and often have long half-lives. Their persistence and relevant toxicity ar…
View article: Exploratory Assessment of Preconception Phthalate Exposure on Fertility and Offspring Health in Mice
Exploratory Assessment of Preconception Phthalate Exposure on Fertility and Offspring Health in Mice Open
Infertility affects 10–15% of couples worldwide and is increasingly attributed to environmental exposures, particularly endocrine-disrupting chemicals (EDCs) such as phthalates. While gestational exposures are well studied, little is known…
View article: Variability of Mercury Concentrations Across Species, Brand, and Tissue Type in Processed Commercial Seafood Products
Variability of Mercury Concentrations Across Species, Brand, and Tissue Type in Processed Commercial Seafood Products Open
Mercury (Hg) is a global health concern due to its prevalence, persistence, and toxicity. Numerous studies have assessed Hg concentrations in seafood, but variability in reported concentrations highlights the need for continued monitoring …
View article: Novel PFAS in Alligator Blood Discovered with Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry
Novel PFAS in Alligator Blood Discovered with Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry Open
Per- and polyfluoroalkyl substances (PFAS) are a large and growing class of chemicals gaining global attention due to their persistence, mobility, and toxicity. Given the diverse chemical properties of PFAS and their varying distributions …
View article: Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes
Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes Open
Per- and polyfluoroalkyl substances (PFAS) are a class of over 8000 chemicals, many of which are persistent, bioaccumulative, and toxic to humans, livestock, and wildlife. Serum protein binding affinity is instrumental in understanding PFA…
View article: Quantitative Cross-Species Comparison of Serum Albumin Binding of Per- and Polyfluoroalkyl Substances from Five Structural Classes
Quantitative Cross-Species Comparison of Serum Albumin Binding of Per- and Polyfluoroalkyl Substances from Five Structural Classes Open
Per- and polyfluoroalkyl substances (PFAS) are a class of over 8,000 chemicals that are persistent, bioaccumulative, and toxic to humans, livestock, and wildlife. Serum protein binding affinity is instrumental in understanding PFAS toxicit…
View article: Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray’s Creek North Carolina
Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray’s Creek North Carolina Open
Central North Carolina (NC) is highly contaminated with per- and polyfluoroalkyl substances (PFAS), in part due to local fluorochemical production. Little is known about the exposure profiles and long-term health impacts for humans and ani…
View article: Developmental sex-specific transcriptomic patterns can be altered by transgenic expression of Uty
Developmental sex-specific transcriptomic patterns can be altered by transgenic expression of Uty Open
The genetic material encoded on X and Y chromosomes provides the foundation by which biological sex differences are established. Epigenetic regulators expressed on these sex chromosomes, including Kdm6a ( Utx ), Kdm5c , and Ddx3x have far-…
View article: Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy
Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy Open
Homeostatic regulation of the maternal milieu during pregnancy is critical for maternal and fetal health. The placenta facilitates critical communication between maternal and fetal compartments, in part, through the production of extracell…
View article: Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat
Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat Open
Organophosphate flame retardants (OPFRs) have become the predominant substitution for legacy brominated flame retardants but there is concern about their potential developmental neurotoxicity (DNT). OPFRs readily dissociate from the firepr…
View article: A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior
A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior Open
Per- and polyfluoroalkyl substances (PFAS) are a class of structurally diverse synthetic organic chemicals that are chemically stable, resistant to degradation, and persistent in terrestrial and aquatic environments. Widespread use of PFAS…
View article: Comparative Assessment of Blood Mercury in American Alligators (Alligator mississippiensis) from Coastal North Carolina and Florida
Comparative Assessment of Blood Mercury in American Alligators (Alligator mississippiensis) from Coastal North Carolina and Florida Open
Mercury (Hg) is a widespread and potential harmful persistent contaminate of aquatic ecosystems. Except for the northern most populations of American alligators ( Alligator Mississippiensis) found in North Carolina, the potential adverse h…
View article: Colonization at birth with human CST IV cervicovaginal microbiota alters development and increases neonatal mortality in mice
Colonization at birth with human CST IV cervicovaginal microbiota alters development and increases neonatal mortality in mice Open
Summary Profound racial health disparities contribute to maternal-infant morbidity and mortality. An emergent risk factor is the maternal microbiota, whereby compositional alterations impact maternal health and offspring development during…
View article: Developmental Exposure to the Flame Retardant Mixture Firemaster 550 Compromises Adult Bone Integrity in Male but not Female Rats
Developmental Exposure to the Flame Retardant Mixture Firemaster 550 Compromises Adult Bone Integrity in Male but not Female Rats Open
Flame retardants (FRs) are used in a variety of common items from furniture to carpet to electronics to reduce flammability and combustion, but the potential toxicity of these compounds is raising health concerns globally. Organophosphate …
View article: Effects of Prenatal Exposure to a Mixture of Organophosphate Flame Retardants on Placental Gene Expression and Serotonergic Innervation in the Fetal Rat Brain
Effects of Prenatal Exposure to a Mixture of Organophosphate Flame Retardants on Placental Gene Expression and Serotonergic Innervation in the Fetal Rat Brain Open
There is a growing need to understand the potential neurotoxicity of organophosphate flame retardants (OPFRs) and plasticizers because use and, consequently, human exposure, is rapidly expanding. We have previously shown in rats that devel…
View article: Heterozygous mutation of Sonic Hedgehog receptor (Ptch) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice
Heterozygous mutation of Sonic Hedgehog receptor (Ptch) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice Open
Sonic hedgehog (SHH) signaling is essential for the differentiation and migration of early stem cell populations during cerebellar development. Dysregulation of SHH-signaling can result in cerebellar overgrowth and the formation of the bra…
View article: PBDEs Concentrate in the Fetal Portion of the Placenta: Implications for Thyroid Hormone Dysregulation
PBDEs Concentrate in the Fetal Portion of the Placenta: Implications for Thyroid Hormone Dysregulation Open
During pregnancy, the supply of thyroid hormone (TH) to the fetus is critically important for fetal growth, neural development, metabolism, and maintenance of pregnancy. Additionally, in cases where maternal and placental TH regulation is …
View article: OR23-6 The Impact of PBDE Exposure, Fetal Sex, and Gestational Day on Thyroid Hormone Regulation in the Placenta
OR23-6 The Impact of PBDE Exposure, Fetal Sex, and Gestational Day on Thyroid Hormone Regulation in the Placenta Open
During pregnancy, supply of thyroid hormone (TH) is critically important for fetal growth, neural development, metabolism and maintenance of pregnancy. However, when circulating levels of THs in maternal serum are disrupted, there is an in…
View article: EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain
EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain Open
Firemaster 550 (FM 550) is a flame retardant (FR) mixture that has become one of the most commonly used FRs in foam-based furniture and baby products. Human exposure to this commercial mixture, composed of brominated and organophosphate co…
View article: Editor’s Highlight: Transplacental and Lactational Transfer of Firemaster® 550 Components in Dosed Wistar Rats
Editor’s Highlight: Transplacental and Lactational Transfer of Firemaster® 550 Components in Dosed Wistar Rats Open
Firemaster® 550 (FM 550) is a commercial mixture of organophosphate and brominated flame retardants currently in use as a replacement for pentaBDE. Its organophosphate components include triphenyl phosphate (TPHP) and a suite of isopropyla…