Explanipedia

DISP-02. Financial toxicity: frequency, impact, and unmet needs in primary brain malignancy Open

Melissa Myers, Ashley Sumrall, Kris Blackley, Joshua D. Hartzell, Thomas G. Knight , et al. · 2025

Financial toxicity, representing the burden and distress of healthcare costs to patients and families, is high within medical oncology. Oncology nurse navigation (ONN) plays an important role in guiding cancer patients toward resources to …

Proton pump inhibitors and all-cause mortality in colorectal cancer Open

Arunkumar Krishnan, Carolin V. Schneider, Kunal C. Kadakia, Declan Walsh, Saleh A. Alqahtani · 2025

Explainable AI Systems Must Be Contestable: Here's How to Make It Happen Open

Catarina Moreira, Anna Palatkina, Dacia Braca, Declan Walsh, Peter J. Leihn , et al. · 2025

As AI regulations around the world intensify their focus on system safety, contestability has become a mandatory, yet ill-defined, safeguard. In XAI, "contestability" remains an empty promise: no formal definition exists, no algorithm guar…

Nutritional Interventions in Advanced Cancer: Scoping Review Open

Aynur Aktaş, Shirley Thomas, Michelle Barrett, Jessica Sui, J. Deane Waldman , et al. · 2025

Background: It is unclear what evidence supports nutritional advice received by those with advanced cancer. In advanced cancer, the benefits of nutritional interventions are less clear, with no consensus about effectiveness. This uncertain…

Weight Loss in Cancer and the 2017 Common Terminology Criteria for Adverse Events—Dangerous and Misleading Open

Aynur Aktaş, Kunal C. Kadakia, J. Deane Waldman, Declan Walsh · 2025

Accurate toxicity reporting in cancer clinical trials is necessary to promote regulatory decision making. Up to 85% of those with some cancers (e.g., oesophagus, head and neck, and pancreas) experience significant progressive weight loss (…

Improving predictive accuracy of early recurrence in pancreatic ductal adenocarcinoma: Role of postoperative serum tumor markers Open

Arunkumar Krishnan, Declan Walsh · 2024

In a recent study by He et al , the nomogram integrates postoperative serum tumor markers such as carbohydrate antigen 19-9 and carcinoembryonic antigen, thereby improving the accuracy of identifying high-risk patients compared to relying …

Sputum culture contamination and associated characteristics in a diagnostic clinical trial, Papua New Guinea Open

ND. Tenakanai, Jennifer Banamu, Yongtao Lin, Declan Walsh, R. Simbil , et al. · 2024

SETTINGPapua New Guinea is a high-burden multidrug-resistant TB (MDR/RR-TB) country that reports low rates of bacteriological confirmation. Sputum drug susceptibility testing for second-line drugs is important. Access to culture is limited…

Proton pump inhibitors and all-cause mortality risk among cancer patients Open

Arunkumar Krishnan, Carolin V. Schneider, Declan Walsh · 2024

BACKGROUND Proton pump inhibitors (PPIs) are widely used, including among cancer patients, to manage gastroesophageal reflux and other gastric acid-related disorders. Recent evidence suggests associations between long-term PPI use and high…

Association between incretin-based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: A large population-based matched cohort study Open

Arunkumar Krishnan, Carolin V. Schneider, Hendrik‐Tobias Arkenau, Ezequiel Mauro, Alejandro Forner , et al. · 2024

GLP-1RAs and DPP-4Is were not associated with a significantly increased risk of CCA. GLP-1RAs even showed a reduced risk of CCA development. They can be considered as safe and effective treatment options for patients with T2DM at risk of C…

Correction to: Opioid analgesic dose and route conversion ratio studies: a scoping review to inform an eDelphi guideline Open

Mellar P. Davis, Andrew Davies, Mary Lynn McPherson, Akhila Reddy, Judith A. Paice , et al. · 2024

Interlaboratory Comparison of SpermX™ and Conventional Differential Extractions Indicated High Male DNA Recovery by the SpermX Method Open

Joanne B. Sgueglia, Hailey Holt, Erin Hanson, Justina Nichols, Tim Kalafut , et al. · 2023

The National Institute of Justice reported that current methods for processing sexual assault samples have a high failure rate, with 60 to 80 percent of tested kits unable to produce usable DNA profiles. Even when samples test positive for…

Interlaboratory Comparison of SpermX™ and Conventional Differential Extractions Indicated High Male DNA Recovery by the SpermX Method Open

Joanne B Sgueglia, Hailey Holt, Erin Hanson, Justina Nichols, Tim Kalafut , et al. · 2023

The National Institute of Justice reported that current methods for processing sexual assault samples have a high failure rate, with 60 to 80 percent of tested kits unable to produce usable DNA profiles. Even when samples test positive for…

PO-3 Cancer inpatient malnutrition risk, documentation, and underdiagnosis in an academic medical center Open

Aynur Aktaş, Lenna Finch, Danielle Boselli, Declan Walsh, Kunal C. Kadakia , et al. · 2023

We evaluated prevalence of MN risk, dietitian documented MN (DDMN), physician coded malnutrition (PCMN) in consecutive inpatients with solid tumors. EMR reviewed for admissions (2016–2019). High MN risk (≥2 on Malnutrition Screening Tool;…

L3 Supportive oncology: a novel department in a major US cancer institute Open

Declan Walsh · 2023

The first palliative medicine program in the US was established in 1987 at the Cleveland Clinic. A broader concept of Supportive Oncology based on the Cleveland experience is in development at the Levine Cancer Institute in Charlotte, Nor…

Taste and smell abnormalities in advanced cancer: Negative impact on subjective food intake Open

Aidan O’Donoghue, Michelle Barrett, Pauline Uí Dhuibhir, Aileen Kennedy, Norma O’Leary , et al. · 2023

Background Taste and smell abnormalities (TSAs) are present in all cancer stages and may contribute to malnutrition. Despite this, they are rarely screened for. This study examined the prevalence and characteristics of TSAs and their influ…

Myocardial strain: a clinical review Open

Bernadette Brady, Gerard King, Ross T. Murphy, Declan Walsh · 2022

Cardiovascular Vital Signs at Solid Tumor Diagnosis: Hypotension and Tachycardia Predict Shorter Overall Survival Open

Aynur Aktaş, Declan Walsh, Wael Lasheen, Bernadette Brady, Michelle Barrett , et al. · 2022

Objective: We examined whether cardiovascular vital signs (VS) were prognostic for overall survival (OS) in newly diagnosed adult cancer outpatients. Methods: Electronic medical records data for patients with a solid tumor diagnosis and ≥2…

Dysphagia in Solid Tumors Outside the Head, Neck or Upper GI Tract: Clinical Characteristics Open

Ciarán Kenny, Julie Regan, Lucy Balding, Stephen P. Higgins, Norma O’Leary , et al. · 2022

Dysphagia management in those with cancer requires robust assessment to uncover clinically important needs like food texture modification and safe swallowing advice. Better assessment tools should be developed for this purpose. Oral health…

Platform Incorporating Patient Navigation, Preparative Guidelines, and Hospital at Home May Improve COVID-19 Outcomes for Patients with Myeloid Malignancies Open

Brittany Knick Ragon, Tamara K. Moyo, Ashley Sumrall, Ifeyinwa Osunkwo, Kris Blackley , et al. · 2021

Background: Patients (pts) with malignancies are at increased risk of morbidity and mortality from COVID-19. Among these pts, some of the higher case fatality ratios (CFR) reported are among pts with myeloid malignancies, ranging from 37 t…

Malnutrition risk at solid tumor diagnosis: the malnutrition screening tool in a large US cancer institute Open

Kunal C. Kadakia, James T. Symanowski, Aynur Aktaş, Michele Szafranski, Jonathan C. Salo , et al. · 2021

Malnutrition Risk at Solid Tumor Diagnosis: the Malnutrition Screening Tool in a Large US Cancer Institute Open

Kunal C. Kadakia, James T. Symanowski, Aynur Aktaş, Michele Szafranski, Jonathan C. Salo , et al. · 2021

BackgroundIn cancer, malnutrition (MN) is common and negatively impacts tolerance and outcomes of anti-tumor therapies. The aim of this study was to evaluate the prevalence of MN risk and compare the clinicodemographic features between tho…

Management of Dyspnea in Advanced Cancer: ASCO Guideline Open

David Hui, Kari Bohlke, Ting Bao, Toby C. Campbell, Patrick J. Coyne , et al. · 2021

PURPOSE To provide guidance on the clinical management of dyspnea in adult patients with advanced cancer. METHODS ASCO convened an Expert Panel to review the evidence and formulate recommendations. An Agency for Healthcare Research and Qua…

EEG Correlates of Central Origin of Cancer-Related Fatigue Open

Didier Allexandre, Dilara Seyidova-Khoshknabi, Mellar P. Davis, Vinoth K. Ranganathan, Vlodek Siemionow , et al. · 2020

The neurophysiological mechanism of cancer-related fatigue (CRF) remains poorly understood. EEG was examined during a sustained submaximal contraction (SC) task to further understand our prior research findings of greater central contribut…

Levine Cancer Institute Approach to Pandemic Care of Patients With Cancer Open

Derek Raghavan, Edward S. Kim, Seungjean Chai, Kevin Plate, Edward A. Copelan , et al. · 2020

Patient sources of diet and nutrition information after a cancer diagnosis Open

Amy Mullee, Deirdre Burke, Veronica McSharry, Pauline Uí Dhuibhir, Michelle Barrett , et al. · 2020

Cancer patients experience many diet and nutrition-related problems, which are often under-recognised and under-treated. Research suggests few healthcare professionals discuss dietary information with cancer patients. Consequently, patient…

Correction to: Enteral and parenteral nutrition in cancer patients, a comparison of complication rates: an updated systematic review and (cumulative) meta-analysis Open

Ronald Chow, Éduardo Bruera, Jann Arends, Declan Walsh, Florian Strasser , et al. · 2019

Dysphagia Prevalence and Predictors in Cancers Outside the Head, Neck, and Upper Gastrointestinal Tract Open

Ciarán Kenny, Julie Regan, Lucy Balding, Stephen P. Higgins, Norma O’Leary , et al. · 2019

Malnutrition in Cancer Care: Time to Address the Elephant in the Room Open

Declan Walsh, Michele Szafranski, Aynur Aktaş, Kunal C. Kadakia · 2019

Complex Terrain: Megacities and the Changing Character of Urban Operations Open

Benjamin Jensen, Colleen Borley, Colin Relihan, Michael Howard, Muhammad Akrama , et al. · 2019

This edited volume, composed by military professionals in the Gray Scholars Program at Marine Corps University, describes the changing character of urban operations. The pattern of human settlement and interaction is changing and the futur…

Declan Walsh YOU? Author Swipe