S. Danielle Brown
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View article: Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease
Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease Open
Animal models that accurately reflect COVID-19 are vital for understanding mechanisms of disease and advancing development of improved vaccines and therapeutics. Pigs are increasingly recognized as valuable models for human disease due to …
View article: SARS-CoV-2 infected human ACE2 transgenic pigs develop severe COVID-19-like pathology.
SARS-CoV-2 infected human ACE2 transgenic pigs develop severe COVID-19-like pathology. Open
COVID-19 continues to cause significant morbidity and mortality, with emerging strains rapidly spreading despite substantial immunity through vaccination and previous exposure. Animal models that accurately reflect COVID-19 are vital for t…
View article: Traumatic Brain Injury Characteristics Predictive of Subsequent Sleep-Wake Disturbances in Pediatric Patients
Traumatic Brain Injury Characteristics Predictive of Subsequent Sleep-Wake Disturbances in Pediatric Patients Open
The objective of this study was to determine the prevalence of sleep-wake disturbances (SWD) following pediatric traumatic brain injury (TBI), and to examine characteristics of TBI and patient demographics that might be predictive of subse…
View article: Comparison of autograft versus allograft in the surgical repair of pediatric obstetrical brachial plexus injuries
Comparison of autograft versus allograft in the surgical repair of pediatric obstetrical brachial plexus injuries Open
OBJECTIVE The goal of this study was to determine the functional efficacy of acellular processed nerve allograft (ALG) as compared to sural nerve autograft (AUG) harvested at time of surgery for children with obstetrical brachial plexus in…
View article: Effect of Administration of Neuromuscular Blocking Agents in Children With Severe Traumatic Brain Injury on Acute Complication Rates and Outcomes
Effect of Administration of Neuromuscular Blocking Agents in Children With Severe Traumatic Brain Injury on Acute Complication Rates and Outcomes Open
Administration of neuromuscular blocking agents was ubiquitous and daily administration of neuromuscular blocking agents was associated with intracranial hypertension but not outcomes-likely indicating that increased injury severity prompt…