Daniëlle Straub
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View article: Inhibition of the BMP pathway prevents development of Barrett’s-associated adenocarcinoma in a surgical rat model
Inhibition of the BMP pathway prevents development of Barrett’s-associated adenocarcinoma in a surgical rat model Open
Summary Introduction Esophageal adenocarcinoma (EAC) is an aggressive cancer, associated with reflux esophagitis and intestinal metaplasia (IM). One underlying biological mechanism, which possibly drives the development of EAC, is the dysr…
View article: Novel In Vivo Mouse Cryoablation Model to Explore Unique Therapeutic Approaches for Premalignant Columnar Lesions
Novel In Vivo Mouse Cryoablation Model to Explore Unique Therapeutic Approaches for Premalignant Columnar Lesions Open
Patients with epithelial metaplasias have an increased risk of developing malignancies. In Barrett’s esophagus, neo-columnar epithelium develops proximal to the squamous-columnar junction (SCJ) in the esophagus as the result of prolonged e…
View article: Using the mouse to study Barrett’s Esophagus : We ain’t that different after all
Using the mouse to study Barrett’s Esophagus : We ain’t that different after all Open
The main risk factor for developing Barrett's esophagus (BE), a precursor of adenocarcinoma, is reflux. BE is defined as the replacement of normal esophageal epithelium with cylindrical (gastric or intestinal type) epithelium in the lower …
View article: Glyco-conjugated bile acids drive the initial metaplastic gland formation from multi-layered glands through crypt-fission in a murine model
Glyco-conjugated bile acids drive the initial metaplastic gland formation from multi-layered glands through crypt-fission in a murine model Open
Bile acid reflux is known to be associated with the development of Barrett's esophagus and esophageal adenocarcinoma (EAC), yet the role of specific bile acids and the mechanism behind the metaplastic changes is unclear. Here, we demonstra…
View article: Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus
Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus Open
Surveillance of Barrett’s oesophagus allows us to study the evolutionary dynamics of a human neoplasm over time. Here we use multicolour fluorescence in situ hybridization on brush cytology specimens, from two time points with a median int…