Danilo Negro
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View article: Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures Open
View article: Opposing roles of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Opposing roles of physiological and pathological amyloid-β on synapses in live human brain slice cultures Open
In Alzheimer’s disease, it is theorised that amyloid beta (Aβ) and tau pathology contribute to synapse loss. However, there is limited information on how endogenous levels of tau and Aβ protein relate to patient characteristics, or how man…
View article: Cognitive resilience in Alzheimer’s disease: from large-scale brain networks to synapses
Cognitive resilience in Alzheimer’s disease: from large-scale brain networks to synapses Open
This scientific commentary refers to ‘Alteration of functional connectivity network in population of objectively-defined subtle cognitive decline’ by Zhang et al. (https://doi.org/10.1093/braincomms/fcae033) and ‘Posterior cingulate cortex…
View article: Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids
Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids Open
The transcription factor PAX6 is a crucial regulator of multiple aspects of embryonic forebrain development. Its well-known roles in mice include regulating differentiation of excitatory and inhibitory neurons in the embryonic cortex. PAX6…