Danke Wang
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View article: Synergistic and heterogeneous aging using composite phenotypes and multiple organ systems aging clocks
Synergistic and heterogeneous aging using composite phenotypes and multiple organ systems aging clocks Open
The overlap between composite phenotypes and biological age provides valuable insights into multi-phenotypic aging. The unearthing of the heterogeneity in aging processes could further inform the development of personalized interventions t…
View article: Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia
Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia Open
Lipid metabolism disorders in both neurons and glial cells have been found in neurodegenerative (ND) patients and animal models. However, the pathological connection between lipid droplets and NDs remains poorly understood. The recent work…
View article: Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities
Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities Open
Background DNA methylation (DNAm) influences both sex differences and cancer development, yet the mechanisms connecting these factors remain unclear. Methods Utilizing data from The Cancer Genome Atlas, we conducted a comprehensive analysi…
View article: Extend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project
Extend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project Open
View article: Transcriptomic Profiling Identified Hub Genes Linking Barrett’s Esophagus and Esophageal Adenocarcinoma
Transcriptomic Profiling Identified Hub Genes Linking Barrett’s Esophagus and Esophageal Adenocarcinoma Open
Background Barrett’s esophagus (BE) is a common type of metaplasia and is recognized as a precursor of esophageal adenocarcinoma (EAC). However, the gene expression pattern underlying the progression of BE and EAC remains to be comprehensi…
View article: Molecular subtyping of esophageal squamous cell carcinoma by large-scale transcriptional profiling: Characterization, therapeutic targets, and prognostic value
Molecular subtyping of esophageal squamous cell carcinoma by large-scale transcriptional profiling: Characterization, therapeutic targets, and prognostic value Open
The tumor heterogeneity of the transcriptional profiles is independent of genetic variation. Several studies have successfully identified esophageal squamous cell carcinoma (ESCC) subtypes based on the somatic mutation profile and copy num…