Danlu Jiang
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View article: AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation
AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation Open
The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase‐1 activation and interleukin‐1β maturation and drives cell fate toward pyroptosis. However, the mechanism of NLRP3 inflammasome activation still rema…
View article: An ionic control of metabolic-epigenetic reprogramming links inflammation to membrane potential-mediated nutrient acquisition
An ionic control of metabolic-epigenetic reprogramming links inflammation to membrane potential-mediated nutrient acquisition Open
Metabolic and epigenetic reprogramming play pivotal roles in driving inflammation, but the precise regulatory mechanisms remain minimally understood. Here we show an ionic control mediated by macrophage Kir2.1, an inwardly-rectifying K+ ch…