Danlu Jiang
2020
An ionic control of metabolic-epigenetic reprogramming links inflammation to membrane potential-mediated nutrient acquisition
2020 • Di Wang, Weiwei Yu, Zhen Wang, Xiafei Yu, Zhexu Chi, Kailian Zhang, Sheng Chen, Ting Xu, Danlu Jiang, Xingchen Guo, Mobai Li, Jian Zhang, Hui Fang,...
2021
AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation
2021 • Xingchen Guo, Sheng Chen, Weiwei Yu, Zhexu Chi, Zhen Wang, Ting Xu, Jian Zhang, Danlu Jiang, Yuxian Guo, Hui Fang, Kailian Zhang, Mobai Li, Dehang...
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Exploring foci of
2021-08-13
AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation
2021-08-13 • Xingchen Guo, Sheng Chen, Weiwei Yu, Zhexu Chi, Zhen Wang, Ting Xu, Jian Zhang, Danlu Jiang, Yuxian Guo, Hui Fang, Kailian Zhang, Mobai Li, Dehang...
The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase‐1 activation and interleukin‐1β maturation and drives cell fate toward pyroptosis. However, the mechanism of NLRP3 inflammasome activation still remains elusive. Here we provide evidence that AKT regulates NLRP3 inflammasome activation. Upon NLRP3 activation, AKT activity is inhibited by second stimulus‐induced reactive oxygen species. In contrast, AKT activation leads to NLRP3 inhibition and improved mitochondrial fitness. M…
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Price Controls
Car Controls
Johnson Controls
Coordinating Committee For Multilateral Export Controls
Information Technology Controls
Youtube Rewind 2018: Everyone Controls Rewind
Security Controls
Hierarchy Of Hazard Controls
Inflammasome
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Exploring foci of
2020-10-09
An ionic control of metabolic-epigenetic reprogramming links inflammation to membrane potential-mediated nutrient acquisition
2020-10-09 • Di Wang, Weiwei Yu, Zhen Wang, Xiafei Yu, Zhexu Chi, Kailian Zhang, Sheng Chen, Ting Xu, Danlu Jiang, Xingchen Guo, Mobai Li, Jian Zhang, Hui Fang,...
Abstract Metabolic and epigenetic reprogramming play pivotal roles in driving inflammation, but the precise regulatory mechanisms remain minimally understood. Here we show an ionic control mediated by macrophage Kir2.1, an inwardly-rectifying K+ channel, promting lipopolysaccharide (LPS)-induced inflammation. Kir2.1 blockade by the selective inhibitor ML133 or its specific deletion in macrophages suppressed the production of LPS-induced inflammatory factors, such as interleukin-1β, and protected mice from LPS-indu…
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Control (2007 Film)
Lighting Control System
Control (Janet Jackson Album)
Star Control Ii
User Account Control
Command And Control
No Control (Eddie Money Album)
Lose Control (Teddy Swims Song)
Setpoint (Control System)
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