Danlu Yang
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View article: Association of choroid plexus volume with white matter microstructure, glymphatic function, and peripheral systemic inflammation in Alzheimer’s disease
Association of choroid plexus volume with white matter microstructure, glymphatic function, and peripheral systemic inflammation in Alzheimer’s disease Open
There has been growing attention to the role of choroid plexus (CP) in neurodegenerative diseases. However, its relationship with various pathophysiological changes in Alzheimer’s Disease (AD) remains unclear. The purpose of this study is …
View article: Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling: Erratum
Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling: Erratum Open
[This corrects the article DOI: 10.7150/thno.60031.].
View article: Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's‐related phenotypes
Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's‐related phenotypes Open
INTRODUCTION Interferon‐induced transmembrane protein 3 (IFITM3) modulates γ‐secretase in Alzheimer's Disease (AD). Although IFITM3 knockout reduces amyloid β protein (Aβ) production, its cell‐specific effect on AD remains unclear. METHODS…
View article: Erratum: β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling.
Erratum: β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling. Open
[This corrects the article on p. 370 in vol. 11, PMID: 33575077.].
View article: β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling: Am J Cancer Res. 2021; 11(2): 370-388
β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling: Am J Cancer Res. 2021; 11(2): 370-388 Open
In this article, we found that a mistake happened during figure organization: the same typical images of C6 cells treated with 10 μg/ml β-elemene for 2 days were inadvertently shown in both Figure 1A and 1G.So, we would like to publish thi…
View article: YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury Open
The horizontal basal cells (HBCs) of olfactory epithelium (OE) serve as reservoirs for stem cells during OE regeneration, through proliferation and differentiation, which is important in recovery of olfactory function. However, the molecul…
View article: High-Efficiency Genome Editing Based on Endogenous CRISPR-Cas System Enhances Cell Growth and Lactic Acid Production in Pediococcus acidilactici
High-Efficiency Genome Editing Based on Endogenous CRISPR-Cas System Enhances Cell Growth and Lactic Acid Production in Pediococcus acidilactici Open
A rapid and precise genome editing tool will promote the practical application of Pediococcus acidilactici , one type of lactic acid bacteria with excellent stress tolerance and probiotic characteristics. This study established a high-effi…
View article: Bioactive substances and potentiality of marine microalgae
Bioactive substances and potentiality of marine microalgae Open
Microalgae is one of the most important components in the aquatic ecosystem, and they are increasingly used in food and medicine production for human consumption due to their rapid growth cycle and survival ability in the harsh environment…
View article: Astrocytic YAP Protects the Optic Nerve and Retina in an Experimental Autoimmune Encephalomyelitis Model Through TGF-β Signaling
Astrocytic YAP Protects the Optic Nerve and Retina in an Experimental Autoimmune Encephalomyelitis Model Through TGF-β Signaling Open
BackgroundOptic neuritis, inflammation of the optic nerve (ON), is one of the main symptoms in multiple sclerosis (MS) and leads to visual disability. Astrocytes are pivotal regulators of neuroinflammation in MS. However, it remains unclea…
View article: Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling
Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling Open
Rationale: Optic neuritis is one of main symptoms in multiple sclerosis (MS) that causes visual disability. Astrocytes are pivotal regulators of neuroinflammation in MS, and astrocytic yes-associated protein (YAP) plays a critical role in …
View article: SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling
SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling Open
Axonal degeneration is a common pathological feature in many acute and chronic neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif-containing 1), the fifth TLR (Toll-like receptor) adaptor, has divers…
View article: Regulation and optimization of water activity and quality of intermediate-moisture potato frozen cake
Regulation and optimization of water activity and quality of intermediate-moisture potato frozen cake Open
The deterioration of cakes during frozen storage is a notorious phenomenon. This study aimed to evaluate the effects of cryoprotectants (collagen peptide, sericin peptide, and curdlan) on the intermediate-moisture cake during frozen storag…
View article: β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling.
β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling. Open
Glioma is currently the most widespread and malignant primary intracranial tumor, which is characterized by high heterogeneity and high fatality rates. β-elemene, which is a bioactive compound extracted from a Chinese herb, Curcuma wenyuji…
View article: D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway
D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway Open
Treatment of glioblastoma using radiotherapy and chemotherapy has various outcomes, key among them being cellular senescence. However, the molecular mechanisms of this process remain unclear. In the present study, we tested the ability of …
View article: SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury
SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury Open
Background Axonal degeneration is a common pathological feature in many acute and chronic neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif containing 1), the fifth TLR (Toll-like receptor) adaptor,…
View article: Astrocytic YAP Promotes the Formation of Glia Scars and Neural Regeneration after Spinal Cord Injury
Astrocytic YAP Promotes the Formation of Glia Scars and Neural Regeneration after Spinal Cord Injury Open
Yes-associated protein (YAP) transcriptional coactivator is negatively regulated by the Hippo pathway and functions in controlling the size of multiple organs, such as liver during development. However, it is not clear whether YAP signalin…
View article: YAP promotes the proliferation of neuroblastoma cells through decreasing the nuclear location of p27<sup>Kip1</sup> mediated by Akt
YAP promotes the proliferation of neuroblastoma cells through decreasing the nuclear location of p27<sup>Kip1</sup> mediated by Akt Open
Objective We aimed to investigate the roles and underlying mechanisms of YAP in the proliferation of neuroblastoma cells. Methods The expression level of YAP was evaluated by Western blotting and immunocytochemistry. Cell viability, cell p…
View article: Effect of Amorphization Methods on the Properties and Structures of Potato Starch‐Monoglyceride Complex
Effect of Amorphization Methods on the Properties and Structures of Potato Starch‐Monoglyceride Complex Open
Recently, starch‐based fat replacers (FRs) have emerged as unique ingredients, possessing few calories and high vascular scavenger function without adverse organoleptic changes. Here, a two‐step modification method for the development of a…
View article: Sympathetic and parasympathetic innervation in hepatocellular carcinoma
Sympathetic and parasympathetic innervation in hepatocellular carcinoma Open
Autonomic nervous system plays an important role in the development of multiple cancers via regulating cancer cell proliferation, differentiation, apoptosis, migration and invasion. However, no detailed studies have been performed to study…