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View article: Effect of Blood Purification on Early Response in Children With Hemophagocytic Lymphohistiocytosis
Effect of Blood Purification on Early Response in Children With Hemophagocytic Lymphohistiocytosis Open
To evaluate the impact of blood purification (BP) therapy on early treatment response and overall survival (OS) in paediatric haemophagocytic lymphohistiocytosis (HLH). We retrospectively reviewed HLH cases from 2012 to 2022, comparing out…
View article: Survival prediction for Philadelphia chromosome-like acute lymphoblastic leukemia by machine learning analysis: a multicenter cohort study
Survival prediction for Philadelphia chromosome-like acute lymphoblastic leukemia by machine learning analysis: a multicenter cohort study Open
Background This study aimed to develop an efficient survival model for predicting event-free survival (EFS) in patients with Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL). Methods Data related to Ph-like ALL were col…
View article: Association of Patient-Reported Outcome Patterns and Major Clinical Factors with Frailty in Stable COPD
Association of Patient-Reported Outcome Patterns and Major Clinical Factors with Frailty in Stable COPD Open
Patients with stable COPD can be categorized based on patient-reported outcomes, with differences in demographic and disease characteristics across subgroups. Patients with severe COPD symptoms revealed higher levels of frailty compared to…
View article: The involvement of mitochondria in erythrocyte pathology and diseases: from mechanisms to therapeutic strategies
The involvement of mitochondria in erythrocyte pathology and diseases: from mechanisms to therapeutic strategies Open
Erythrocytes, as the predominant cellular components within the bloodstream, are crucial for the maintenance of physiological health. Mitochondria, known as cellular powerhouses and metabolic regulators, play a critical role in the maturat…
View article: Evidence of honey‐processed <i>Astragalus</i> polysaccharides improving intestinal immune <scp>function</scp> in spleen Qi deficiency mice integrated with microbiomics and metabolomics analysis
Evidence of honey‐processed <i>Astragalus</i> polysaccharides improving intestinal immune <span>function</span> in spleen Qi deficiency mice integrated with microbiomics and metabolomics analysis Open
BACKGROUND Radix Astragali, commonly known as Astragalus , is a traditional medicinal and edible plant valued for its Qi‐tonifying properties. The dosage form of Radix Astragali processed with honey, known as honey‐processed Astragalus (HP…
View article: Risk factors for premature rupture of membranes in pregnant women: a systematic review and meta-analysis
Risk factors for premature rupture of membranes in pregnant women: a systematic review and meta-analysis Open
Objective To identify risk factors for premature rupture of membranes (PROM) in pregnant women. Design Systematic review and meta-analysis. Data sources Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastruct…
View article: Therapies and Treatment Responses for Hemophagocytic Lymphohistiocytosis in Children: A Single-center Retrospective Study
Therapies and Treatment Responses for Hemophagocytic Lymphohistiocytosis in Children: A Single-center Retrospective Study Open
Hemophagocytic lymphohistiocytosis (HLH) is a severe and life-threatening systemic inflammatory disorder. This retrospective study aims to evaluate the effectiveness of different therapies and identify early treatment responses maybe for i…
View article: A Single-center Retrospective Report Therapies and Treatment Responses for Hemophagocytic Lymphohistiocytosis in Children: Is Blood Purification Beneficial?
A Single-center Retrospective Report Therapies and Treatment Responses for Hemophagocytic Lymphohistiocytosis in Children: Is Blood Purification Beneficial? Open
Background Hemophagocytic lymphohistiocytosis (HLH) is a severe and life-threatening systemic inflammatory disorder. This study aims to evaluate the effectiveness of different therapies and identify early treatment responses as potential i…
View article: Vemurafenib combined with chemotherapy achieved sustained remission in pediatric LCH: a multi-center observational study
Vemurafenib combined with chemotherapy achieved sustained remission in pediatric LCH: a multi-center observational study Open
Background Langerhans cell histiocytosis (LCH) is a myeloid neoplasia with potentially fatal consequences, and about 2/3 of cases involve the BRAF V600E kinase-activated mutation. Vemurafenib, a BRAF inhibitor, has demonstrated significant…
View article: Poor outcome of pediatric B-cell acute lymphoblastic leukemia associated with high level of CRLF2 gene expression in distinct molecular subtypes
Poor outcome of pediatric B-cell acute lymphoblastic leukemia associated with high level of CRLF2 gene expression in distinct molecular subtypes Open
Background Overexpression of the cytokine receptor-like factor 2 (CRLF2) gene is the most common feature in the Philadelphia chromosome (Ph)-like subtype of B-cell acute lymphoblastic leukemia (B-ALL). However, the predictive value of CRLF…
View article: Disseminated Fusarium solani infection in a child with acute lymphocytic leukemia: A case report and literature review
Disseminated Fusarium solani infection in a child with acute lymphocytic leukemia: A case report and literature review Open
Background: Although invasive mycosis is a common complication of hematologic malignancies, invasive Fusarium infection, especially systemic disseminated Fusarium infection is rare, which has a high mortality due to remarkable intrinsic dr…
View article: Population pharmacokinetics of posaconazole in Chinese pediatric patients with acute leukaemia: Effect of food on bioavailability and dose optimization
Population pharmacokinetics of posaconazole in Chinese pediatric patients with acute leukaemia: Effect of food on bioavailability and dose optimization Open
This study aimed to investigate the effect of food on the pharmacokinetics of posaconazole suspension in pediatric patients with acute leukaemia and to recommend optimal dosing strategies. This single-site, prospective, open-label, observa…
View article: Case report: Compound heterozygous mutations in the KDSR gene cause progressive keratodermia and thrombocytopenia
Case report: Compound heterozygous mutations in the KDSR gene cause progressive keratodermia and thrombocytopenia Open
KDSR (3-ketodihydrosphingosine reductase) is a short-chain dehydrogenase located in the endoplasmic reticulum. Mutations in KDSR cause defects in ceramides, which play a key role in the biological processes of the skin and other tissues. H…
View article: Case Report: Reversible Hyperglycemia Following Rapamycin Treatment for Atypical Choroid Plexus Papilloma in an Infant
Case Report: Reversible Hyperglycemia Following Rapamycin Treatment for Atypical Choroid Plexus Papilloma in an Infant Open
In this study, atypical choroid plexus papilloma was treated with high-dose rapamycin for 17 days preoperatively in an infant. Rapamycin significantly reduced the blood supply to the tumor while reducing the tumor volume, and most of the t…
View article: Diagnosis and outcomes of pediatric central nervous system tumors in China: a single-center retrospective analysis from 2015 to 2020
Diagnosis and outcomes of pediatric central nervous system tumors in China: a single-center retrospective analysis from 2015 to 2020 Open
Background: A primary central nervous system (CNS) tumor is the most common solid tumor among children, but few systematic and comprehensive studies on childhood CNS tumors in China. We aim to review the characteristics, treatments, and pr…
View article: [Prognostic significance of IKZF1 gene deletions in patients with B-cell acute lymphoblastic leukemia].
[Prognostic significance of IKZF1 gene deletions in patients with B-cell acute lymphoblastic leukemia]. Open
Objective: This study aimed to investigate the prognostic significance of IKZF1 gene deletion in patients with acute B lymphoblastic leukemia (B-ALL) . Methods: The clinical data of 142 patients with B-ALL diagnosed in Nanfang Hospital bet…
View article: Prognostic Value and Outcome for ETV6/RUNX1-Positive Pediatric Acute Lymphoblastic Leukemia: A Report From the South China Children’s Leukemia Group
Prognostic Value and Outcome for ETV6/RUNX1-Positive Pediatric Acute Lymphoblastic Leukemia: A Report From the South China Children’s Leukemia Group Open
Purpose To analyzed the outcome of ETV6/RUNX1-positive pediatric acute B lymphoblastic leukemia (B-ALL) with the aim of identifying prognostic value. Method A total of 2,530 pediatric patients who were diagnosed with B-ALL were classified …
View article: GD2-specific Chimeric Antigen Receptor-modified T Cells for the treatment of Refractory and/or Recurrent Neuroblastoma in Pediatric Patients
GD2-specific Chimeric Antigen Receptor-modified T Cells for the treatment of Refractory and/or Recurrent Neuroblastoma in Pediatric Patients Open
PurposeThis study aimed to evaluate the safety and efficacy of the fourth-generation chimeric antigen receptor (CAR) disialoganglioside 2 (GD2)-specific (4SCAR-GD2) T cells for treatment of refractory and/or recurrent neuroblastoma (NB) in…
View article: [Diagnosis of adult Philadelphia chromosome-like acute lymphoblastic leukemia by fluorescence in situ hybridization].
[Diagnosis of adult Philadelphia chromosome-like acute lymphoblastic leukemia by fluorescence in situ hybridization]. Open
Objective: To establish a screening system of adult Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) by fluorescence in situ hybridization (FISH) . Method: Based on the genetic characteristics of Ph-like ALL, FISH pr…
View article: Development and Validation of a Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry Method for the Determination of Asparagine in Human Serum
Development and Validation of a Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry Method for the Determination of Asparagine in Human Serum Open
L-Asparagine (ASN) is the catalyze substrate of L-asparaginase (ASNase), which is an important drug for acute lymphoblastic leukemia (ALL) patients. The ASN level is found to be closely associated with the effectiveness of ASNase treatment…
View article: [Characteristics and prognosis in adult patients with early T-cell precursor acute lymphoblastic leukemia].
[Characteristics and prognosis in adult patients with early T-cell precursor acute lymphoblastic leukemia]. Open
Objective: To analyze the clinical, laboratory characteristics and prognosis of adult early T-cell precursor acute lymphoblastic leukemia (ETP-ALL). Methods: The clinical data of 13 adult ETP-ALL patients from January 2009 to March 2017 we…
View article: Endoplasmic reticulum stress plays an important role in methotrexate-related cognitive impairment in adult rats.
Endoplasmic reticulum stress plays an important role in methotrexate-related cognitive impairment in adult rats. Open
The patients receiving methotrexate (MTX) treatment are inclined to suffer from cognition impairment, since MTX can induce apoptosis of neurons, while the underlying molecular mechanisms remain unknown. Thus we hypothesized that MTX-induce…