Danny Brouard
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View article: Monitoring of Staphylococcus epidermidis biofilm formation on platelet storage bag surfaces
Monitoring of Staphylococcus epidermidis biofilm formation on platelet storage bag surfaces Open
Platelet concentrates (PCs) are stored at 20–24˚C in a biologically favorable environment that may support bacterial growth. Staphylococcus epidermidis , a typical contaminant, can form biofilms in PCs, complicating detection and increasin…
View article: Dynamic monitoring of Staphylococcus epidermidis biofilm formation using a microfluidic approach
Dynamic monitoring of Staphylococcus epidermidis biofilm formation using a microfluidic approach Open
The crystal violet (CV) assay was the standard for quantifying biofilm biomass but is limited by its inability to replicate dynamic environmental conditions. In contrast, microfluidic flow cells provided a promising alternative, enabling r…
View article: Estimating retinal blood oxygenation from diffuse reflectance spectra of semi-infinite tissue using principal component analysis
Estimating retinal blood oxygenation from diffuse reflectance spectra of semi-infinite tissue using principal component analysis Open
Diffuse reflectance spectroscopy (DRS) is a promising technique for non-invasive monitoring of tissue oxygen saturation (StO 2 ). However, the interpretation of DRS data can be complicated by the presence of confounding factors such as the…
View article: A portable surface plasmon resonance (<scp>SPR</scp>) sensor for the detection of immunoglobulin <scp>A</scp> in plasma
A portable surface plasmon resonance (<span>SPR</span>) sensor for the detection of immunoglobulin <span>A</span> in plasma Open
Background A life‐threatening anaphylactic shock can occur if a patient with undiagnosed immunoglobulin A (IgA) deficiency (i.e., IgA levels <500 ng/mL) receives IgA‐containing blood, hence the need for a rapid, point‐of‐care (POC) method …
View article: Synthesis and antibacterial properties of unmodified polydopamine coatings to prevent infections
Synthesis and antibacterial properties of unmodified polydopamine coatings to prevent infections Open
Health-care-associated infections (HAIs) can occur if a contaminated product bypasses current tests and prophylactic measures. These contaminations may be missed due to low bacterial loads or the presence of adhered biofilms. Antibacterial…
View article: Assessment of the longitudinal humoral response in non-hospitalized SARS-CoV-2-positive individuals at decentralized sites: Outcomes and concordance
Assessment of the longitudinal humoral response in non-hospitalized SARS-CoV-2-positive individuals at decentralized sites: Outcomes and concordance Open
Introduction Early in the COVID-19 pandemic, reagent availability was not uniform, and infrastructure had to be urgently adapted to undertake COVID-19 surveillance. Methods Before the validation of centralized testing, two enzyme-linked im…
View article: Monte-Carlo simulation and tissue-phantom model for validation of ocular oximetry
Monte-Carlo simulation and tissue-phantom model for validation of ocular oximetry Open
Ocular oximetry, in which blood oxygen saturation is evaluated in retinal tissues, is a promising technique for the prevention, diagnosis and management of many diseases and conditions. However, the development of new tools for evaluating …
View article: Characterization of the Antibacterial Activity of an SiO2 Nanoparticular Coating to Prevent Bacterial Contamination in Blood Products
Characterization of the Antibacterial Activity of an SiO2 Nanoparticular Coating to Prevent Bacterial Contamination in Blood Products Open
Technological innovations and quality control processes within blood supply organizations have significantly improved blood safety for both donors and recipients. Nevertheless, the risk of transfusion-transmitted infection remains non-negl…
View article: Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native and B.1.351 SARS-CoV-2 spike proteins
Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native and B.1.351 SARS-CoV-2 spike proteins Open
SARS-CoV-2 variants of concern (VOCs) have emerged worldwide, with implications on the spread of the pandemic. Characterizing the cross-reactivity of antibodies against these VOCs is necessary to understand the humoral response of non-hosp…
View article: Cross-Validation of ELISA and a Portable Surface Plasmon Resonance Instrument for IgG Antibodies Serology with SARS-CoV-2 Positive Individuals
Cross-Validation of ELISA and a Portable Surface Plasmon Resonance Instrument for IgG Antibodies Serology with SARS-CoV-2 Positive Individuals Open
We report on the development of surface plasmon resonance (SPR) sensors and matching ELISAs for the detection of nucleocapsid and spike antibodies specific against the novel coronavirus 2019 (SARS-CoV-2) in human serum, plasma and dried bl…
View article: Cross-Validation of ELISA and a Portable Surface Plasmon Resonance Instrument for IgG Antibodies Serology with SARS-CoV-2 Positive Individuals
Cross-Validation of ELISA and a Portable Surface Plasmon Resonance Instrument for IgG Antibodies Serology with SARS-CoV-2 Positive Individuals Open
We report on the development of surface plasmon resonance (SPR) sensors and matching ELISAs for the detection of nucleocapsid and spike antibodies specific against the novel coronavirus 2019 (SARS-CoV-2) in human serum, plasma and dried bl…
View article: Cross-validation of ELISA and a portable surface plasmon resonance instrument for IgG antibody serology with SARS-CoV-2 positive individuals
Cross-validation of ELISA and a portable surface plasmon resonance instrument for IgG antibody serology with SARS-CoV-2 positive individuals Open
We report on the development of surface plasmon resonance (SPR) sensors and matching ELISAs for the detection of nucleocapsid and spike antibodies specific to the novel coronavirus 2019 (SARS-CoV-2) in human serum, plasma and dried blood s…
View article: Drone versus ground delivery of simulated blood products to an urban trauma center: The Montreal Medi-Drone pilot study
Drone versus ground delivery of simulated blood products to an urban trauma center: The Montreal Medi-Drone pilot study Open
BACKGROUND Timely and safe distribution of quality blood products is a major challenge faced by blood banks around the world. Our primary objective was to determine if simulated blood product delivery to an urban trauma center would be mor…
View article: Evaluation of the Tempo® System: Improving the Microbiological Quality Monitoring of Human Milk
Evaluation of the Tempo® System: Improving the Microbiological Quality Monitoring of Human Milk Open
Background: Bacteriological testing of donor human milk is mostly done both before and after pasteurization to control contamination in the end-product and meet the microbiological standards. Although the plate count method represents a re…
View article: Development of a flow standard to enable highly reproducible measurements of deformability of stored red blood cells in a microfluidic device
Development of a flow standard to enable highly reproducible measurements of deformability of stored red blood cells in a microfluidic device Open
BACKGROUND Great deformability allows red blood cells (RBCs) to flow through narrow capillaries in tissues. A number of microfluidic devices with capillary‐like microchannels have been developed to monitor storage‐related impairment of RBC…
View article: Fluorescent core-shell alloy nanoparticles for cell targeting applications
Fluorescent core-shell alloy nanoparticles for cell targeting applications Open
Event Abstract Back to Event Fluorescent core-shell alloy nanoparticles for cell targeting applications Siyu Tu1, Danny Brouard2, Josée Perreault2, Eric Bergeron1, David Rioux1 and Michel Meunier1 1 Polytechnique Montréal, Department of En…
View article: Internalization of targeted quantum dots by brain capillary endothelial cells in vivo
Internalization of targeted quantum dots by brain capillary endothelial cells in vivo Open
Receptors located on brain capillary endothelial cells forming the blood–brain barrier are the target of most brain drug delivery approaches. Yet, direct subcellular evidence of vectorized transport of nanoformulations into the brain is la…