Explanipedia

Evaluating machine learning accuracy in detecting significant coronary stenosis using CCTA-derived fractional flow reserve: Meta-analysis and systematic review Open

Danny van Noort, Liang Guo, Shuang Leng, Luming Shi, Ru‐San Tan , et al. · 2024

3D printed fluidic swab for COVID-19 testing with improved diagnostic yield and user comfort Open

Joochan Kim, Jae‐Hyung Jeon, Hyowon Jang, Youngkwang Moon, Abdurhaman Teyib Abafogi , et al. · 2023

3D Printed Fluidic Swab for COVID-19 Testing with Improved Diagnostic Yield and User Comfort Open

Joochan Kim, Jae‐Hyung Jeon, Hyowon Jang, Youngkwang Moon, Abdurhaman Teyib Abafogi , et al. · 2023

The current standard method of diagnosing coronavirus disease 2019 (COVID-19) involves uncomfortable and invasive nasopharyngeal (NP) sampling using cotton swabs (CS), which can be unsuitable for self-testing. Although mid-turbinate sampli…

Isosceles Trapezoidal Spiral Microchannel for Separation of Large particles and Giant Cancer cells Open

Chan-Yong Park, Wanyoung Lim, Ryungeun Song, Jeonghun Han, Daeun You , et al. · 2023

Background: Polyploid giant cancer cells (PGCCs) contribute to the genetic heterogeneity and evolution of tumor cells. To study these cells, they need to be separated from tumor cell populations. However, due to their large size it is chal…

3D hanging spheroid plate for high-throughput CAR T cell cytotoxicity assay Open

Zhenzhong Chen, Seokgyu Han, Arleen Sanny, Dorothy Chan, Danny van Noort , et al. · 2022

Organ-on-a-Chip for Studying Gut-Brain Interaction Mediated by Extracellular Vesicles in the Gut Microenvironment Open

Minhyeok Kim, Danny van Noort, Jong Hwan Sung, Sungsu Park · 2021

Extracellular vesicles (EVs) are a group of membrane vesicles that play important roles in cell-to-cell and interspecies/interkingdom communications by modulating the pathophysiological conditions of recipient cells. Recent evidence has im…

3D Hanging Spheroid Plate for High-Throughput CAR T Cell Cytotoxicity Assay Open

Zhenzhong Chen, Seokgyu Han, Arleen Sanny, Dorothy Chan, Danny van Noort , et al. · 2021

Background Most high-throughput screening (HTS) systems for the cytotoxic effect of chimeric antigen receptor (CAR) T cells on tumor cells rely on two-dimensional cell culture that does not suitably recapitulate the tumor microenvironment …

Systematic Review: Microfluidics and Plasmodium Open

Nicolas Thorne, Luis Flores-Olazo, Rocío Egoávil-Espejo, Emir A. Vela, Julien Noel , et al. · 2021

Malaria affects 228 million people worldwide each year, causing severe disease and worsening the conditions of already vulnerable populations. In this review, we explore how malaria has been detected in the past and how it can be detected …

3D-Printed Modular Microfluidic Device Enabling Preconcentrating Bacteria and Purifying Bacterial DNA in Blood for Improving the Sensitivity of Molecular Diagnostics Open

Abdurhaman Teyib Abafogi, Jaewon Kim, Jinyeop Lee, Merem Omer Mohammed, Danny van Noort , et al. · 2020

Molecular diagnostics for sepsis is still a challenge due to the presence of compounds that interfere with gene amplification and bacteria at concentrations lower than the limit of detection (LOD). Here, we report on the development of a 3…

Integrated Microfluidic Preconcentration and Nucleic Amplification System for Detection of Influenza A Virus H1N1 in Saliva Open

Yong-Hee Kim, Abdurhaman Teyib Abafogi, Buu Minh Tran, Jaewon Kim, Jinyeop Lee , et al. · 2020

Influenza A viruses are often present in environmental and clinical samples at concentrations below the limit of detection (LOD) of molecular diagnostics. Here we report an integrated microfluidic preconcentration and nucleic amplification…

Microslit on a chip: A simplified filter to capture circulating tumor cells enlarged with microbeads Open

Seung Joon Lee, Tae Seok Sim, Hyun Young Shin, Jungmin Lee, Min Young Kim , et al. · 2019

Microchips are widely used to separate circulating tumor cells (CTCs) from whole blood by virtues of sophisticated manipulation for microparticles. Here, we present a chip with an 8 μm high and 27.9 mm wide slit to capture cancer cells bou…

Microfluidics for Cells and Other Organisms Open

Danny van Noort, Iordania Constantinou, Michael Jendrusch, Théo Aspert, Frederik Görlitz , et al. · 2019

Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, per…

Editorial for the Special Issue on Microfluidics for Cells and Other Organisms Open

Danny van Noort · 2019

It is my great pleasure to present to you this first volume of 13 papers on the subject of Microfluidics for Cells and other Organisms [...]

A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion Open

Yi‐Chin Toh, Anju M. Raja, Hanry Yu, Danny van Noort · 2018

We have developed a microfluidic-based culture chip to simulate cancer cell migration and invasion across the basement membrane. In this microfluidic chip, a 3D microenvironment is engineered to culture metastatic breast cancer cells (MX1)…

Solenoid Driven Pressure Valve System: Toward Versatile Fluidic Control in Paper Microfluidics Open

Taehoon H. Kim, Young Ki Hahn, Jungmin Lee, Danny van Noort, Minseok S. Kim · 2018

As paper-based diagnostics has become predominantly driven by more advanced microfluidic technology, many of the research efforts are still focused on developing reliable and versatile fluidic control devices, apart from improving sensitiv…

Developing organ-on-a-chip concepts using bio-mechatronic design methodology Open

Jonas Christoffersson, Danny van Noort, Carl‐Fredrik Mandenius · 2017

Mechatronic design is an engineering methodology for conceiving, configuring and optimising the design of a technical device or product to the needs and requirements of the final user. In this article, we show how the basic principles of t…

Endocrine system on chip for a diabetes treatment model Open

Thuy Nguyen Thi Dao, Danny van Noort, In‐Kyung Jeong, Sungsu Park · 2017

The endocrine system is a collection of glands producing hormones which, among others, regulates metabolism, growth and development. One important group of endocrine diseases is diabetes, which is caused by a deficiency or diminished effec…

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