Dansha He
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View article: Mouse model systems of autism spectrum disorder: Replicability and informatics signature
Mouse model systems of autism spectrum disorder: Replicability and informatics signature Open
Phenotyping mouse model systems of human disease has proven to be a difficult task, with frequent poor inter‐ and intra‐laboratory replicability, particularly in behavioral domains such as social and cognitive function. However, establishi…
View article: Mouse Model Systems of Autism Spectrum Disorder: Replicability and Informatics Signature
Mouse Model Systems of Autism Spectrum Disorder: Replicability and Informatics Signature Open
3. Abstract Background Phenotyping mouse model systems of human disease has proven to be a difficult task, with frequent poor inter- and intra-laboratory replicability and translatability, particularly in behavioral domains such as social …
View article: Comprehensive Analysis of Two <i>Shank3</i> and the Cacna1c Mouse Models of Autism Spectrum Disorder
Comprehensive Analysis of Two <i>Shank3</i> and the Cacna1c Mouse Models of Autism Spectrum Disorder Open
To expand, analyze and extend published behavioral phenotypes relevant to autism spectrum disorder (ASD), we present a study of three ASD genetic mouse models: Feng’s Shank3 tm2Gfng model, hereafter Shank3/F , Jiang’s Shank3 tm1Yhj model, …
View article: Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD
Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD Open
Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive deficits in the zQ17…
View article: Acquisition and reversal in the procedural T-maze.
Acquisition and reversal in the procedural T-maze. Open
In the procedural T-maze mice are trained to reach a platform on one side of the maze. After they perform correctly 6 out of 8 trials in two consecutive days, the platform position is reversed and mice are trained under the new rule. A: Th…
View article: Overall visit frequency detected in the PhenoCube system as a function of genotype, age and light cycle phase in animals from the zQ175×TG2 KO line.
Overall visit frequency detected in the PhenoCube system as a function of genotype, age and light cycle phase in animals from the zQ175×TG2 KO line. Open
*Significant HD genotype differences regardless of the light phase (in the mean path length the differences were detected between HET and WT animals); ##significant differences due to light phase in the cycle independently of genotype; ∧si…
View article: Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder
Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder Open
Autism spectrum disorder comprises several neurodevelopmental conditions presenting symptoms in social communication and restricted, repetitive behaviors. A major roadblock for drug development for autism is the lack of robust behavioral s…