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View article: CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors
CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors Open
The mitotic inhibitor docetaxel (DTX) is often used to treat endocrine-refractory metastatic breast cancer, but initial responses are mitigated as patients develop disease progression. Using a cohort of ex vivo cultured circulating tumor c…
View article: <i>CDKN1B</i>(p27<sup>kip1</sup>) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors
<i>CDKN1B</i>(p27<sup>kip1</sup>) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors Open
The mitotic inhibitor docetaxel (DTX) is often used to treat endocrine-refractory metastatic breast cancer, but initial responses are mitigated as patients eventually have disease progression. Using a cohort of ex vivo cultures of circulat…
View article: A Gene Panel Associated With Abemaciclib Utility in <i>ESR1</i>-Mutated Breast Cancer After Prior Cyclin-Dependent Kinase 4/6-Inhibitor Progression
A Gene Panel Associated With Abemaciclib Utility in <i>ESR1</i>-Mutated Breast Cancer After Prior Cyclin-Dependent Kinase 4/6-Inhibitor Progression Open
PURPOSE For patients with hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) metastatic breast cancer (MBC), first-line treatment is endocrine therapy (ET) plus cyclin-dependent kinase 4/6 inhibition…
View article: TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state Open
TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influen…
View article: Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody
Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody Open
The successful application of antibody-based therapeutics in either primary or metastatic cancer depends upon the selection of rare cell surface epitopes that distinguish cancer cells from surrounding normal epithelial cells. By contrast, …
View article: Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition
Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition Open
Cancer therapy often results in heterogeneous responses in different metastatic lesions in the same patient. Inter- and intratumor heterogeneity in signaling within various tumor compartments and its impact on therapy are not well characte…