Danusa Mar Arcego
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View article: Sex-specific interaction effects of Syntaxin 1A coexpression network and childhood trauma on adult depressive symptoms
Sex-specific interaction effects of Syntaxin 1A coexpression network and childhood trauma on adult depressive symptoms Open
View article: Extra virgin olive oil supplementation attenuates hippocampal inflammation in high-fat diet-induced obesity animals with a depressive phenotype
Extra virgin olive oil supplementation attenuates hippocampal inflammation in high-fat diet-induced obesity animals with a depressive phenotype Open
View article: Insulin modulates mPFC gene expression and emotional behavior in a sex-specific manner following fetal growth restriction
Insulin modulates mPFC gene expression and emotional behavior in a sex-specific manner following fetal growth restriction Open
Exposure to prenatal adversity (e.g., stress, malnutrition) is a major risk factor for lifelong vulnerability to neuropsychiatric and metabolic disorders, and alterations in the function of peripheral hormones in the brain are suggested as…
View article: Striatal dopamine gene network moderates the effect of early adversity on the risk for adult psychiatric and cardiometabolic comorbidity
Striatal dopamine gene network moderates the effect of early adversity on the risk for adult psychiatric and cardiometabolic comorbidity Open
View article: Relationship between maternal biological features, environmental factors, and newborn neuromotor development associated with visual fixation abilities
Relationship between maternal biological features, environmental factors, and newborn neuromotor development associated with visual fixation abilities Open
Newborn visual fixation abilities predict future cognitive, perceptive, and motor skills. However, little is known about the factors associated with the newborn visual fixation, which is an indicator of neurocognitive abilities. We analyze…
View article: Expression based polygenic scores - A gene network perspective to capture individual differences in biological processes
Expression based polygenic scores - A gene network perspective to capture individual differences in biological processes Open
Incorporating functional aspects into polygenic scores may accelerate early diagnosis and the discovery of therapeutic targets. Yet, existing polygenic scores summarize information from genome wide statistical associations between SNPs and…
View article: Effects of prenatal maternal immune activation and exposure to circadian disruption during adolescence: exploring the two-hit model of neurodevelopmental disorders
Effects of prenatal maternal immune activation and exposure to circadian disruption during adolescence: exploring the two-hit model of neurodevelopmental disorders Open
Background Around 80% of individuals with neurodevelopmental disorders (NDDs) such as schizophrenia and autism spectrum disorders experience disruptions in sleep/circadian rhythms. We explored whether prenatal infection, an established ris…
View article: SEX-DIFFERENCES IN THE LONG-TERM EFFECTS OF EARLY LIFE ADVERSITY IN THE NUCLEUS ACCUMBENS TRANSCRIPTOME
SEX-DIFFERENCES IN THE LONG-TERM EFFECTS OF EARLY LIFE ADVERSITY IN THE NUCLEUS ACCUMBENS TRANSCRIPTOME Open
View article: Sex and cell-specific gene expression in corticolimbic brain regions associated with psychiatric disorders revealed by bulk and single-nuclei RNA sequencing
Sex and cell-specific gene expression in corticolimbic brain regions associated with psychiatric disorders revealed by bulk and single-nuclei RNA sequencing Open
This work was supported by funding from the Hope for Depression Research Foundation (MJM).
View article: A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes Open
We provide an approach for the use of transcriptomic data from animal models together with human data to study the impact of environmental influences on mental health. The results are consistent with the hypothesis that hippocampal glucoco…
View article: Editorial: Early life events: shedding light on neurobiological mechanisms
Editorial: Early life events: shedding light on neurobiological mechanisms Open
EDITORIAL article Front. Behav. Neurosci., 17 May 2023Sec. Learning and Memory Volume 17 - 2023 | https://doi.org/10.3389/fnbeh.2023.1209494
View article: Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children
Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children Open
View article: Examining attachment, cortisol secretion, and cognitive neurodevelopment in preschoolers and its predictive value for telomere length at age seven
Examining attachment, cortisol secretion, and cognitive neurodevelopment in preschoolers and its predictive value for telomere length at age seven Open
Background Secure attachment reflects caregiver-child relationship in which the caregiver is responsive when support and comforting are needed by the child. This pattern of bond has an important buffering role in the response to stress by …
View article: Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling
Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling Open
View article: Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children
Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children Open
Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children We created an expression-based polygenic risk score (ePRS) reflecting variations in the function of LepR gene network in…
View article: Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine
Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine Open
View article: Striatal dopamine gene network moderates the effect of early adversity on the risk for adult psychiatric and cardiometabolic comorbidity
Striatal dopamine gene network moderates the effect of early adversity on the risk for adult psychiatric and cardiometabolic comorbidity Open
Cardiometabolic and psychiatric disorders often co-exist and share common early life risk factors, such as low birth weight. However, the biological pathways linking early adversity to adult cardiometabolic/psychiatric comorbidity remain u…
View article: Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network
Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network Open
Background: Previous studies focused on the relationship between prenatal conditions and neurodevelopmental outcomes later in life, but few have explored the interplay between gene co-expression networks and prenatal adversity conditions o…
View article: Life-course effects of early life adversity exposure on eating behavior and metabolism
Life-course effects of early life adversity exposure on eating behavior and metabolism Open
View article: Expression-based polygenic score from the amygdala 5HTT gene network
Expression-based polygenic score from the amygdala 5HTT gene network Open
This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step descrip…
View article: Expression-based polygenic score from the amygdala 5HTT gene network
Expression-based polygenic score from the amygdala 5HTT gene network Open
This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step descrip…
View article: Expression-based polygenic score from the amygdala 5HTT gene network
Expression-based polygenic score from the amygdala 5HTT gene network Open
This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step descrip…
View article: Expression-based polygenic score from the amygdala 5HTT gene network
Expression-based polygenic score from the amygdala 5HTT gene network Open
This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step descrip…
View article: SUN-722 Liver Leptin Receptor Gene Network Moderates the Effects of Early Life Adversity on Anxiety and Depression Problems in Children and Adolescents
SUN-722 Liver Leptin Receptor Gene Network Moderates the Effects of Early Life Adversity on Anxiety and Depression Problems in Children and Adolescents Open
Leptin is a hormone involved in the regulation of food intake, with receptors largely expressed centrally and peripherally, in structures like the hypothalamus and the liver. Beyond its well-known actions as an energy-balance regulator, le…
View article: MON-722 Cross-Species Glucocorticoid-Sensitive Posterior Dentate Gyrus Gene Network: Developing a Polygenic Score Associated to Susceptibility to Depression After Early Life Adversity Exposure in Humans
MON-722 Cross-Species Glucocorticoid-Sensitive Posterior Dentate Gyrus Gene Network: Developing a Polygenic Score Associated to Susceptibility to Depression After Early Life Adversity Exposure in Humans Open
Exposure to stress during the life-course has consistently been associated with neuropsychological disorders, but the precise role of stress released glucocorticoids remains unclear in this context. We aimed at using hippocampal gene expre…
View article: Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes
Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes Open
Variations in serotoninergic signaling have been related to behavioral outcomes. Alterations in the genome, such as DNA methylation and histone modifications, are affected by serotonin neurotransmission. The amygdala is an important brain …
View article: Isolamento social precoce e consumo de uma dieta hiperlipídica : implicações no comportamento do tipo depressivo e em aspectos cognitivos em ratos adultos
Isolamento social precoce e consumo de uma dieta hiperlipídica : implicações no comportamento do tipo depressivo e em aspectos cognitivos em ratos adultos Open
Intervenções ambientais, como a exposição precoce a estressores ou a dietas ricas em calorias, podem alterar a trajetória da maturação neural e influenciar na susceptibilidade a certas patologias a longo-prazo. Neste contexto, o objetivo d…
View article: Neonatal interventions differently affect maternal care quality and have sexually dimorphic developmental effects on corticosterone secretion
Neonatal interventions differently affect maternal care quality and have sexually dimorphic developmental effects on corticosterone secretion Open
Neonatal handling (H) and maternal separation (MS) both induce changes in maternal care, but the contribution of these changes to the behavioral and neurochemical outcomes of the offspring remains unclear, as studies often find opposite re…