Danuta M. Sampson
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View article: Automated Cone Photoreceptor Detection in Adaptive Optics Flood Illumination Ophthalmoscopy
Automated Cone Photoreceptor Detection in Adaptive Optics Flood Illumination Ophthalmoscopy Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration:<i>HTRA1</i>/lncRNA<i>BX842242.1</i>dominates, with no evidence for Complement Cascade involvement
Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration:<i>HTRA1</i>/lncRNA<i>BX842242.1</i>dominates, with no evidence for Complement Cascade involvement Open
Age-related macular degeneration (AMD) is a multifactorial retinal disease with a large genetic risk contribution. Reticular pseudodrusen (RPD) is a sub-phenotype of AMD with a high risk of progression to late vision threatening AMD. In a …
View article: Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA
Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA Open
Quantitative assessment of retinal microvasculature in optical coherence tomography angiography (OCTA) images is important for studying, diagnosing, monitoring, and guiding the treatment of ocular and systemic diseases. However, the OCTA u…
View article: Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people
Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people Open
Optical coherence tomography angiography (OCTA) is a non-invasive, high-resolution imaging modality with growing application in dermatology and microvascular assessment. Accepted reference values for OCTA-derived microvascular parameters i…
View article: Age-Dependent Decline in Common Femoral Artery Flow-Mediated Dilation and Wall Shear Stress in Healthy Subjects
Age-Dependent Decline in Common Femoral Artery Flow-Mediated Dilation and Wall Shear Stress in Healthy Subjects Open
Femoral artery (FA) endothelial function is a promising biomarker of lower extremity vascular health for peripheral artery disease (PAD) prevention and treatment; however, the impact of age on FA endothelial function has not been reported …
View article: Correcting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length
Correcting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length Open
Background To generate and validate a method to estimate axial length estimated (AL est ) from spherical equivalent (SE) and corneal curvature [keratometry (K)], and to determine if this AL est can replace actual axial length (AL act ) for…
View article: Impact of Reference Center Choice on Adaptive Optics Imaging Cone Mosaic Analysis
Impact of Reference Center Choice on Adaptive Optics Imaging Cone Mosaic Analysis Open
There is a marked mismatch between the AMC and FPC in healthy eyes that may be modified by disease process such as rod-cone dystrophy. We recommend users of AO imaging systems carefully align the AO montage with a foveal anatomical landmar…
View article: Towards standardizing retinal optical coherence tomography angiography: a review
Towards standardizing retinal optical coherence tomography angiography: a review Open
View article: Cocoa flavanol consumption improves lower extremity endothelial function in healthy individuals and people with type 2 diabetes
Cocoa flavanol consumption improves lower extremity endothelial function in healthy individuals and people with type 2 diabetes Open
T2DM individuals exhibit macro- and microvascular dysfunction that is pronounced in the legs. Cocoa acutely increases endothelial function of the brachial and the femoral arteries and dilation of microvasculature in the feet of T2DM and he…
View article: Short-Term Parafoveal Cone Loss Despite Preserved Ellipsoid Zone in Rod Cone Dystrophy
Short-Term Parafoveal Cone Loss Despite Preserved Ellipsoid Zone in Rod Cone Dystrophy Open
CD and ICD may change prior to EZ span shortening in RCD.
View article: OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images
OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images Open
Optical coherence tomography angiography (OCTA) performs non-invasive visualization and characterization of microvasculature in research and clinical applications mainly in ophthalmology and dermatology. A wide variety of instruments, imag…
View article: OCTAVA: an open-source toolbox for quantitative analysis of optical coherence tomography angiography images
OCTAVA: an open-source toolbox for quantitative analysis of optical coherence tomography angiography images Open
This is a dataset of OCTA images used in the development of the manuscript OCTAVA: an open-source toolbox for quantitative analysis of optical coherence tomography angiography images
View article: OCTAVA: an open-source toolbox for quantitative analysis of optical coherence tomography angiography images
OCTAVA: an open-source toolbox for quantitative analysis of optical coherence tomography angiography images Open
This is a dataset of OCTA images used in the development of the manuscript OCTAVA: an open-source toolbox for quantitative analysis of optical coherence tomography angiography images
View article: Evaluation of focus and deep learning methods for automated image grading and factors influencing image quality in adaptive optics ophthalmoscopy
Evaluation of focus and deep learning methods for automated image grading and factors influencing image quality in adaptive optics ophthalmoscopy Open
View article: Retinal Differential Light Sensitivity Variation Across the Macula in Healthy Subjects: Importance of Cone Separation and Loci Eccentricity
Retinal Differential Light Sensitivity Variation Across the Macula in Healthy Subjects: Importance of Cone Separation and Loci Eccentricity Open
Cone density is an independent determinant of DLS in the foveal-parafoveal junction in healthy eyes.
View article: Multimodal Retinal Imaging and Microperimetry Reveal a Novel Phenotype and Potential Trial End Points in <i>CRB1</i>-Associated Retinopathies
Multimodal Retinal Imaging and Microperimetry Reveal a Novel Phenotype and Potential Trial End Points in <i>CRB1</i>-Associated Retinopathies Open
Macular volume and sensitivity can be used as structural and functional end points for trials on CRB1-associated RP and MD.
View article: Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography
Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography Open
This study demonstrates the potential of speckle decorrelation OCTA for measuring localized peripheral cutaneous pulsatility and defines scanning protocols necessary to undertake such measurements. Noncontact imaging should be used for the…
View article: RTVue XR AngioVue Optical Coherence Tomography Angiography Software Upgrade Impacts on Retinal Thickness and Vessel Density Measurements
RTVue XR AngioVue Optical Coherence Tomography Angiography Software Upgrade Impacts on Retinal Thickness and Vessel Density Measurements Open
RT and VD measures derived from the newer AngioVue software version are not directly comparable to the reported normative data derived from the older software.
View article: In vivo brain imaging with multimodal optical coherence microscopy in a mouse model of thromboembolic photochemical stroke
In vivo brain imaging with multimodal optical coherence microscopy in a mouse model of thromboembolic photochemical stroke Open
We used a new multimodal imaging system that combines optical coherence microscopy and brightfield microscopy. Using this in vivo brain monitoring approach and cranial window implantation, we three-dimensionally visualized the vascu…
View article: Automatic Detection of Cone Photoreceptors With Fully Convolutional Networks
Automatic Detection of Cone Photoreceptors With Fully Convolutional Networks Open
Manual cone photoreceptor identification is a time-consuming task due to the large number of cones present within a single image; using the proposed FCN-based method could support the image analysis task, drastically reducing the need for …
View article: Clinical validation of the RTVue optical coherence tomography angiography image quality indicators
Clinical validation of the RTVue optical coherence tomography angiography image quality indicators Open
Importance All automated image quality indicators for en face optical coherence tomography angiography (OCTA) images require gold standard validation for determining optimum thresholds. Background A manual grading system (gold standard) fo…
View article: Posterior Choroidal Stroma Reduces Accuracy of Automated Segmentation of Outer Choroidal Boundary in Swept Source Optical Coherence Tomography
Posterior Choroidal Stroma Reduces Accuracy of Automated Segmentation of Outer Choroidal Boundary in Swept Source Optical Coherence Tomography Open
Automated outer choroidal boundary segmentation tends to identify the posterior limit of the choroidal vessel. Agreement between A-SFCT and M-SFCT is reduced by the presence of posterior stromal layer and lamina fusca. A-SFCT should be int…
View article: Intrasession Repeatability and Interocular Symmetry of Foveal Avascular Zone and Retinal Vessel Density in OCT Angiography
Intrasession Repeatability and Interocular Symmetry of Foveal Avascular Zone and Retinal Vessel Density in OCT Angiography Open
CRs and LAs can be used to set a threshold for true changes in FAZA and SRVD in longitudinal studies of healthy individuals.
View article: Use of focus measure operators for characterization of flood illumination adaptive optics ophthalmoscopy image quality
Use of focus measure operators for characterization of flood illumination adaptive optics ophthalmoscopy image quality Open
Adaptive optics flood illumination ophthalmoscopy (AO-FIO) allows imaging of the cone photoreceptor in the living human retina. However, clinical interpretation of the AO-FIO image remains challenging due to suboptimal quality arising from…
View article: Agreement in Cone Density Derived from Gaze-Directed Single Images Versus Wide-Field Montage Using Adaptive Optics Flood Illumination Ophthalmoscopy
Agreement in Cone Density Derived from Gaze-Directed Single Images Versus Wide-Field Montage Using Adaptive Optics Flood Illumination Ophthalmoscopy Open
Cone densities from single AO images are not interchangeable with wide-field montage derived-measurements.
View article: Perifoveal interdigitation zone loss in hydroxychloroquine toxicity leads to subclinical bull’s eye lesion appearance on near-infrared reflectance imaging
Perifoveal interdigitation zone loss in hydroxychloroquine toxicity leads to subclinical bull’s eye lesion appearance on near-infrared reflectance imaging Open
View article: Axial Length Variation Impacts on Superficial Retinal Vessel Density and Foveal Avascular Zone Area Measurements Using Optical Coherence Tomography Angiography
Axial Length Variation Impacts on Superficial Retinal Vessel Density and Foveal Avascular Zone Area Measurements Using Optical Coherence Tomography Angiography Open
Ocular biometry should be performed with OCTA to correct image magnification error induced by axial length variation. We advise caution when interpreting interocular and interindividual comparisons of SRVD and FAZA derived from OCTA withou…
View article: Enhanced Visualization of Subtle Outer Retinal Pathology by En Face Optical Coherence Tomography and Correlation with Multi-Modal Imaging
Enhanced Visualization of Subtle Outer Retinal Pathology by En Face Optical Coherence Tomography and Correlation with Multi-Modal Imaging Open
Graph-search theory algorithm helps to overcome the limitations of outer retinal segmentation inaccuracies in commercial software. En face OCT images can provide detailed topography of the reflectivity within a specific layer of the retina…