Danxia Zhou
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View article: Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism Open
Skeletal muscle is a major organ for maintaining whole-body energy balance, yet how it adapts its transcriptional and metabolic programs to environmental cues remains unclear. Here, we report that histone mono-methyltransferase mixed linea…
View article: HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis
HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis Open
Iron is critical to optimal athletic performance because of its role in energy metabolism, oxygen transport, and acid‐base balance. However, the precise mechanism how skeletal muscle maintains iron homeostasis during exercise remains enigm…
View article: Glucose‐Responsive PAGR1‐Regulated Skeletal Muscle Gene Program Controls Systemic Glucose Homeostasis and Hepatic Metabolism
Glucose‐Responsive PAGR1‐Regulated Skeletal Muscle Gene Program Controls Systemic Glucose Homeostasis and Hepatic Metabolism Open
Chronic hyperglycemia, a defining feature of type 2 diabetes (T2D) and related metabolic disorders, exacerbates insulin resistance and impairs muscle glucose utilization, contributing to systemic metabolic dysfunction. While skeletal muscl…
View article: Metabolic Profiling of Cochlear Organoids Identifies α‐Ketoglutarate and NAD<sup>+</sup> as Limiting Factors for Hair Cell Reprogramming
Metabolic Profiling of Cochlear Organoids Identifies α‐Ketoglutarate and NAD<sup>+</sup> as Limiting Factors for Hair Cell Reprogramming Open
Cochlear hair cells are the sensory cells responsible for transduction of acoustic signals. In mammals, damaged hair cells do not regenerate, resulting in permanent hearing loss. Reprogramming of the surrounding supporting cells to functio…
View article: Imbalanced Skeletal Muscle Mitochondrial Proteostasis Causes Bone Loss
Imbalanced Skeletal Muscle Mitochondrial Proteostasis Causes Bone Loss Open
Although microgravity has been implicated in osteoporosis, the precise molecular mechanism remains elusive. Here, we found that microgravity might induce mitochondrial protein buildup in skeletal muscle, alongside reduced levels of LONP1 p…
View article: FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment
FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment Open
Ischaemia of the heart and limbs attributable to compromised blood supply is a major cause of mortality and morbidity. The mechanisms of functional angiogenesis remain poorly understood, however. Here we show that FNIP1 plays a critical ro…
View article: Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4
Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4 Open
Mitochondrial quality in skeletal muscle is crucial for maintaining energy homeostasis during metabolic stresses. However, how muscle mitochondrial quality is controlled and its physiological impacts remain unclear. Here, we demonstrate th…
View article: FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics
FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics Open
Metabolically beneficial beige adipocytes offer tremendous potential to combat metabolic diseases. The folliculin interacting protein 1 (FNIP1) is implicated in controlling cellular metabolism via AMPK and mTORC1. However, whether and how …
View article: Increased glycolysis in skeletal muscle coordinates with adipose tissue in systemic metabolic homeostasis
Increased glycolysis in skeletal muscle coordinates with adipose tissue in systemic metabolic homeostasis Open
Insulin‐independent glucose metabolism, including anaerobic glycolysis that is promoted in resistance training, plays critical roles in glucose disposal and systemic metabolic regulation. However, the underlying mechanisms are not complete…
View article: AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1
AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1 Open
Mitochondria are essential for maintaining skeletal muscle metabolic homeostasis during adaptive response to a myriad of physiologic or pathophysiological stresses. The mechanisms by which mitochondrial function and contractile fiber type …
View article: Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction
Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction Open
Skeletal muscle depends on the precise orchestration of contractile and metabolic gene expression programs to direct fiber-type specification and to ensure muscle performance. Exactly how such fiber type-specific patterns of gene expressio…
View article: Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle
Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle Open
Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate, which are critical fuel metabolites of skeletal muscle particularly during exercise. However, the physiological relevance of LDH remains poorly understood. …