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View article: Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol
Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol Open
Cells experience strong variations in the consumption and availability of inorganic phosphate (Pi). Since Pi is an essential macronutrient but excess Pi has negative impacts on nucleotide hydrolysis and metabolism, its concentration must b…
View article: Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants
Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants Open
Inositol pyrophosphates (PP-InsPs) are soluble cellular messengers that integrate environmental cues to induce adaptive responses in eukaryotes. In plants, the biological functions of various PP-InsP species are poorly understood, largely …
View article: Author response: Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol
Author response: Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol Open
View article: Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol
Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol Open
Cells experience strong variations in the consumption and availability of inorganic phosphate (P i ). Since P i is an essential macronutrient but excess P i has negative impacts on nucleotide hydrolysis and metabolism, its concentration mu…
View article: Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol
Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol Open
Cells experience strong variations in the consumption and availability of inorganic phosphate (Pi). Since Pi is an essential macronutrient but excess Pi has negative impacts on nucleotide hydrolysis and metabolism, its concentration must b…
View article: Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol
Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol Open
Cells experience strong variations in the consumption and availability of inorganic phosphate (Pi). Since Pi is an essential macronutrient but excess Pi has negative impacts on nucleotide hydrolysis and metabolism, its concentration must b…
View article: Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling with <sup>18</sup>O-Water
Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling with <sup>18</sup>O-Water Open
Inositol phosphates control many central processes in eukaryotic cells including nutrient availability, growth, and motility. Kinetic resolution of a key modulator of their signaling functions, the turnover of the phosphate groups on the i…
View article: Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in <i>Trypanosoma cruzi</i>
Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in <i>Trypanosoma cruzi</i> Open
Inositol phosphates are involved in a myriad of biological roles and activities such as Ca 2+ signaling, phosphate homeostasis, energy metabolism, and disease pathogenicity. In Saccharomyces cerevisiae, synthesis of inositol phosphates occ…
View article: ITPK1 is an InsP6/ADP phosphotransferase that controls phosphate signaling in Arabidopsis
ITPK1 is an InsP6/ADP phosphotransferase that controls phosphate signaling in Arabidopsis Open
View article: In-Depth Structure and Function Characterization of Heterogeneous Interchain Cysteine-Conjugated Antibody–Drug Conjugates
In-Depth Structure and Function Characterization of Heterogeneous Interchain Cysteine-Conjugated Antibody–Drug Conjugates Open
Antibody-drug conjugates (ADCs), integrating high specificity of antigen-targeting antibodies and high potency of cell-killing chemical drugs, have become one of the most rapidly expanding therapeutic biologics in oncology. Although ADCs w…
View article: Conservation of heat stress acclimation by the inositol polyphosphate multikinase, IPMK responsible for 4/6-InsP<sub>7</sub>production in land plants
Conservation of heat stress acclimation by the inositol polyphosphate multikinase, IPMK responsible for 4/6-InsP<sub>7</sub>production in land plants Open
Inositol pyrophosphates (PP-InsPs) are soluble cellular messengers that integrate environmental cues to induce adaptive responses in eukaryotes. In plants, the biological functions of various PP-InsP species are poorly understood, largely …
View article: Author Response: Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81
Author Response: Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81 Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract Eukaryotic cells contr…
View article: Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81
Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81 Open
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate. Phosphate homeostasis depends on the conserved INPHORS signaling pathway t…
View article: Inositol Pyrophosphate Dynamics Reveals Control of the Yeast Phosphate Starvation Program Through 1,5-IP8 and the SPX Domain of Pho81
Inositol Pyrophosphate Dynamics Reveals Control of the Yeast Phosphate Starvation Program Through 1,5-IP8 and the SPX Domain of Pho81 Open
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate. Phosphate homeostasis depends on the conserved INPHORS signaling pathway t…
View article: Author Response: Inositol Pyrophosphate Dynamics Reveals Control of the Yeast Phosphate Starvation Program Through 1,5-IP8 and the SPX Domain of Pho81
Author Response: Inositol Pyrophosphate Dynamics Reveals Control of the Yeast Phosphate Starvation Program Through 1,5-IP8 and the SPX Domain of Pho81 Open
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate. Phosphate homeostasis depends on the conserved INPHORS signaling pathway t…
View article: β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner
β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner Open
Inositol pyrophosphates (PP-InsPs) are energetic signaling molecules with important functions in mammals. As their biosynthesis depends on ATP concentration, PP-InsPs are tightly connected to cellular energy homeostasis. Consequently, an i…
View article: Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in <i>Arabidopsis thaliana</i> Chloroplasts through Specific RelA/SpoT Homologues
Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in <i>Arabidopsis thaliana</i> Chloroplasts through Specific RelA/SpoT Homologues Open
Magic spot nucleotides (p)ppGpp are important signaling molecules in bacteria and plants. In the latter, RelA-SpoT homologue (RSH) enzymes are responsible for (p)ppGpp turnover. Profiling of (p)ppGpp is more difficult in plants than in bac…
View article: Systems chemistry of aminoacyl phosphates: Spontaneous and selective peptide oligomerisation in water driven by phase changes
Systems chemistry of aminoacyl phosphates: Spontaneous and selective peptide oligomerisation in water driven by phase changes Open
The pathways and mechanisms that allow spontaneous and selective peptide elongation in aqueous abiotic systems remain unclear. Herein we work to uncover those pathways by following the systems chemistry of aminoacyl phosphates, the synthet…
View article: Reviewer #2 (Public Review): Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81
Reviewer #2 (Public Review): Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81 Open
Eukaryotic cells control cytosolic inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impacts. Phosphate homeostasis depends on a conserved signaling pathway including inositol pyrophosphates …
View article: Reviewer #3 (Public Review): Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81
Reviewer #3 (Public Review): Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81 Open
Eukaryotic cells control cytosolic inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impacts. Phosphate homeostasis depends on a conserved signaling pathway including inositol pyrophosphates …
View article: Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81
Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81 Open
Eukaryotic cells control cytosolic inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impacts. Phosphate homeostasis depends on a conserved signaling pathway including inositol pyrophosphates …
View article: Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81
Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81 Open
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate. Phosphate homeostasis depends on the conserved INPHORS signaling pathway t…
View article: Reviewer #1 (Public Review): Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81
Reviewer #1 (Public Review): Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81 Open
Eukaryotic cells control cytosolic inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impacts. Phosphate homeostasis depends on a conserved signaling pathway including inositol pyrophosphates …
View article: Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in<i>Arabidopsis thaliana</i>Chloroplasts Through Specific RelA/SpoT Homologs
Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in<i>Arabidopsis thaliana</i>Chloroplasts Through Specific RelA/SpoT Homologs Open
Magic spot nucleotides (p)ppGpp are important signaling molecules in bacteria and plants. In the latter, RSH enzymes are responsible for (p)ppGpp turnover. Profiling of (p)ppGpp is more difficult in plants than in bacteria due to lower con…
View article: Metabolic Consequences of Polyphosphate Synthesis and Imminent Phosphate Limitation
Metabolic Consequences of Polyphosphate Synthesis and Imminent Phosphate Limitation Open
Cells must strike a delicate balance between the high demand of inorganic phosphate (P i ) for synthesizing nucleic acids and phospholipids and its detrimental bioenergetic effects by reducing the free energy of nucleotide hydrolysis. The …
View article: Inositol Pyrophosphate Dynamics Reveals Control of the Yeast Phosphate Starvation Program Through 1,5-IP <sub>8</sub> and the SPX Domain of Pho81
Inositol Pyrophosphate Dynamics Reveals Control of the Yeast Phosphate Starvation Program Through 1,5-IP <sub>8</sub> and the SPX Domain of Pho81 Open
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate. Phosphate homeostasis depends on the conserved INPHORS signaling pathway t…
View article: Preparation of poly(<i>N‐</i>vinylpyrrolidone‐co‐pentaerythritol triacrylate) monolithic column for hydrophilic interaction chromatography
Preparation of poly(<i>N‐</i>vinylpyrrolidone‐co‐pentaerythritol triacrylate) monolithic column for hydrophilic interaction chromatography Open
A method for the preparation of poly( N‐ vinylpyrrolidone‐co‐pentaerythritol triacrylate copolymerization)‐based monolithic capillary column was reported for the separation of polar small molecular weight compounds with nano‐liquid chromat…
View article: Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast
Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast Open
Although many prokaryotes have glycolysis alternatives, it's considered as the only energy-generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid-glycolysis yeast. Subsequently, we identified an inositol py…
View article: The phytase RipBL1 enables the assignment of a specific inositol phosphate isomer as a structural component of human kidney stones
The phytase RipBL1 enables the assignment of a specific inositol phosphate isomer as a structural component of human kidney stones Open
Kidney stones and patient urine contain inositol 1,2,3-trisphosphate as demonstrated by capillary electrophoresis mass spectrometry with an internal heavy isotope reference.
View article: Stable Isotopomers of <i>myo-</i>Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network
Stable Isotopomers of <i>myo-</i>Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network Open
The water-soluble inositol phosphates (InsPs) represent a functionally diverse group of small-molecule messengers involved in a myriad of cellular processes. Despite their centrality, our understanding of human InsP metabolism is incomplet…