Explanipedia

Anti-Rubella Immunoglobulin G Proficiency Testing Results Suggest Consistent Manufacturer Differences and Opportunity for Harmonization Open

Rebecca S. Treger, Thomas C. Long, Sally L. Calvey, Danyel H. Tacker, Kamran Kadkhoda , et al. · 2024

To the Editor.—Congenital rubella can cause significant morbidity and mortality but is rare in countries with vaccination and immune status verification programs. Testing for anti–rubella virus immunoglobulin G (IgG) and vaccinating potent…

Educational Case: Multiple myeloma Open

Jerome P. Givi, Nathan Williams, Rotem Hass, Danyel H. Tacker, Aarti Goswami , et al. · 2024

Trends in co-prescribed opioids and benzodiazepines, non-prescribed opioids and benzodiazepines, and schedule-I drugs in the United States, 2013 to 2019 Open

Shaden A. Taha, Jordan Westra, Danyel H. Tacker, Mukaila A. Raji, Yong‐Fang Kuo · 2023

A-315 Pregnant Women Showed Lower Incidence Rates of False-positive Treponemal Antibody Screening Results When Compared with Nonpregnant Women and Men at an Appalachian Academic Medical Center Open

Jianbo Yang, Danyel H. Tacker · 2023

Background Screening for syphilis infection is recommended for all pregnant women and any adult or adolescent with increased risk for infection. Many clinical labs have adopted the reverse syphilis serology testing algorithm, that employs …

A universal reference interval for serum immunoglobulins free light chains may be outdated Open

Susan L. Fink, Mark H. Wener, Joseph W. Rudolf, Ann Nwosu, Danyel H. Tacker , et al. · 2023

Persistence and Protective Potential of SARS-CoV-2 Antibody Levels After COVID-19 Vaccination in a West Virginia Nursing Home Cohort Open

Katy Smoot, Jianbo Yang, Danyel H. Tacker, Shelley Welch, Maryam Khodaverdi , et al. · 2022

In this cross-sectional study, anti-RBD IgG levels decreased after vaccination or infection. Higher antibody responses were found in individuals who received a third (booster) vaccination. Although lower antibody levels were associated wit…

Is Hemodialysis So Efficient in Removing Phosphate? Open

Jianbo Yang, Michael Konietzko, Danyel H. Tacker · 2022

A 16-year-old girl with a complicated medical history including cystic fibrosis, double lung transplant, and end-stage renal disease presented for intermittent hemodialysis 3 times a week.The patient was on a low-phosphorus diet and prescr…

NEJM Knowledge+/AACC Learning Lab Contributors 2021 Open

Jude Abadie, Roger L. Bertholf, Ruth D. Neill, Carey Cotten, A C Deacon , et al. · 2021

Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection Open

Alexander M. Horspool, Theodore Kieffer, Brynnan P. Russ, Megan A. DeJong, M. Allison Wolf , et al. · 2021

The SARS-CoV-2 pandemic is continuing to impact the global population, and knowledge of the immune response to COVID-19 is still developing. This study assesses the interplay of different parts of the immune system during COVID-19 disease.

Interlaboratory Agreement of Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serologic Assays in the Expedited College of American Pathologists Proficiency Testing Program Open

Danyel H. Tacker, Christine Bashleben, Thomas C. Long, Elitza S. Theel, Vijaya Knight , et al. · 2021

Context.— Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged, currently pandemic virus, and the etiologic agent of coronavirus disease 2019 (COVID-19). Clinical testing for antibodies to SARS-CoV-2 has rapid…

How Can Routine Clinical Laboratories Keep Up with the Opioid Crisis? Open

Christine L.H. Snozek, Leland B. Baskin, Jessica M. Boyd, Brian N. Kelly, Matthew D. Krasowski , et al. · 2020

Drug Positivity Findings from a Universal Umbilical Cord Tissue Drug Analysis Program in Appalachia Open

Panitan Yossuck, Danyel H. Tacker · 2020

Background West Virginia has high rates of opioid-related health crises and deaths that extend to pregnant women and newborns. Our institutional screening approach has included universal umbilical cord tissue drug analysis (UCTDA) since 20…

Fentanyl Quality Assurance Project Prompted Change in Clinical Workflow and Test Configurations Open

Danyel H. Tacker, Ayodele Adelanwa, Nathan Pearson, Patrick Marshalek, James H. Berry · 2020

Background Deaths attributable to fentanyl (FEN, a synthetic opioid) are high in Appalachia and highest in West Virginia. The goal of the study was to determine FEN prevalence among specimens submitted for definitive opioid testing and mon…

Interplay of antibody and cytokine production reveals CXCL-13 as a potential novel biomarker of lethal SARS-CoV-2 infection Open

Alexander M. Horspool, Theodore Kieffer, Brynnan P. Russ, Megan A. DeJong, M. Allison Wolf , et al. · 2020

The SARS-CoV-2 pandemic is continuing to impact the global population. This study was designed to assess the interplay of antibodies with the systemic cytokine response in SARS-CoV-2 patients. We demonstrate that significant anti-SARS-CoV-…

Initial Clinical Experience with PCSK9 Inhibitors to Lower LDL Cholesterol in a University Lipid Clinic Setting Open

Anthony P. Morise, Jennifer Tennant, Sari D. Holmes, Danyel H. Tacker · 2020

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have demonstrated significant lowering of low-density lipoprotein (LDL) cholesterol in patients with atherosclerotic cardiovascular disease (ASCVD) and familial hypercholeste…

NEJM Knowledge+/AACC Learning Lab Contributors 2019 Open

Aasne K. Aarsand, Jude Abadie, Alicia Algeciras, David Alter, Fred S. Apple , et al. · 2019

Clinical Utility and Performance in Test Utilization Interventions for Paraneoplastic Antibody Panel Orders: A Delicate Balance Open

Danyel H. Tacker · 2019

The article in this issue of JALM —Utilization Review of Paraneoplastic Neurological Syndrome Antibody Screening Panels: A Single Institution Experience at a Tertiary Academic Health Center—presents an example of addressing a pervasive iss…

The Effect of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Nonfasting Remnant Cholesterol in a Real World Population Open

Anthony P. Morise, Jennifer Tennant, Sari D. Holmes, Danyel H. Tacker · 2018

Background . Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have demonstrated significant effects on low-density lipoprotein (LDL) cholesterol and nonhigh density lipoprotein (HDL) cholesterol. To date, there have been li…

Quality Monitoring Approach for Optimizing Antinuclear Antibody Screening Cutoffs and Testing Work Flow Open

Danyel H. Tacker, Peter L. Perrotta · 2017

Background An antinuclear antibody (ANA) testing strategy involving enzyme immunoassay (EIA) screening that reflexed to immunofluorescence assay (IFA) was implemented, monitored, and optimized for clinical utility. Methods The clinical uti…

Quality Improvement Intervention for Reduction of Redundant Testing Open

Alan Ducatman, Danyel H. Tacker, Barbara S. Ducatman, Dustin Long, Peter L. Perrotta , et al. · 2017

Laboratory data are critical to analyzing and improving clinical quality. In the setting of residual use of creatine kinase M and B isoenzyme testing for myocardial infarction, we assessed disease outcomes of discordant creatine kinase M a…

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