Explanipedia

Incidence and management of appendicitis at 6 years in Shicheng County of China Open

Guanwei Li, Liansheng Chen, Junming Lu, Xie Ji, Dan‐yun Lai , et al. · 2025

Research on the Criminal Liability for Traffic Accidents of Autonomous Vehicles Open

Dan‐yun Lai · 2025

In recent years, China’s automobile industry has improved rapidly, in the premise of making great progress in the field of traditional fuel vehicles. With the development of artificial intelligence technologies such as cloud computing and …

Age- and Severity-Associated Humoral Immunity Response in COVID-19 Patients: A Cohort Study from Wuhan, China Open

An Zhu, Min Liu, Yang Li, Qing Lei, Qiaoyi Wu , et al. · 2022

Age has been found to be the single most significant factor in COVID-19 severity and outcome. However, the age-related severity factors of COVID-19 have not been definitively established. In this study, we detected SARS-CoV-2-specific anti…

Longitudinal neutralization activities on authentic Omicron variant provided by three doses of BBIBP‐CorV vaccination during one year Open

Dan‐yun Lai, Jun‐biao Xue, Ping He, He‐wei Jiang, Li Yang , et al. · 2022

The majority of people in China have been immunized with the inactivated viral vaccine BBIBP‐CorV. The emergence of the Omicron variant raised the concerns about protection efficacy of the inactivated viral vaccine in China. However, longi…

Ultrasensitive monitoring of SARS-CoV-2-specific antibody responses based on a digital approach reveals one week of IgG seroconversion Open

Feiyang Ou, Dan‐yun Lai, Xiaojun Kuang, Ping He, Yang Li , et al. · 2022

Evaluation of Spike Protein Epitopes by Assessing the Dynamics of Humoral Immune Responses in Moderate COVID-19 Open

Lingyun Chen, Pengfei Pang, Huan Qi, Keqiang Yan, Yan Ren , et al. · 2022

The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike protein (S) of SARS-CoV-2 is a major target for diagnosis and vaccine developm…

SARS-CoV-2 proteome microarray for COVID-19 patient sera profiling Open

Dan‐yun Lai, He‐wei Jiang, Li Yang, Hainan Zhang, Sheng‐ce Tao · 2022

SARS-CoV-2-specific antibody response characteristics in COVID-19 patients of different ages Open

Linfang Lu, Siqi Yu, Min Liu, Yang Li, Qing Lei , et al. · 2022

Age has been found to be one of the main risk factors for the severity and outcome of COVID-19. However, differences in SARS-CoV-2 specific antibody responses among COVID-19 patients of different age groups remain largely unknown. In this …

Landscape of the RBD-specific IgG, IgM, and IgA responses triggered by the inactivated virus vaccine against the Omicron variant Open

Jun‐biao Xue, Dan‐yun Lai, He‐wei Jiang, Huan Qi, Shujuan Guo , et al. · 2022

One year landscape of the inactivated virus vaccine triggered RBD-specific IgG, IgM and IgA responses against the Omicron variant Open

Jun‐biao Xue, Dan‐yun Lai, He‐wei Jiang, Jie Zhou, Sheng‐ce Tao · 2022

We reported the first map of vaccine stimulated RBD-specific antibody responses (IgG, IgM and IgA) against the Omicron variant. We generated the map using a protein microarray, by analyzing longitudinal sera collected spanning one year fro…

Longitudinal Neutralization Activities on Authentic Omicron Variant Provided by 3 Doses of BBIBP-CorV Vaccination During One Year Open

Dan‐yun Lai, Jun‐biao Xue, Ping He, He‐wei Jiang, Yang Li , et al. · 2022

Anti-SARS-CoV-2 IgG responses are powerful predicting signatures for the outcome of COVID-19 patients Open

Qing Lei, Caizheng Yu, Yang Li, Hongyan Hou, Zhaowei Xu , et al. · 2021

COVID-ONE-hi: The One-Stop Database for COVID-19-Specific Humoral Immunity and Clinical Parameters Open

Zhaowei Xu, Yang Li, Qing Lei, Likun Huang, Dan‐yun Lai , et al. · 2021

Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, di…

Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy Open

Ming‐liang Ma, Dawei Shi, Yang Li, Wei Hong, Dan‐yun Lai , et al. · 2021

One of the best ways to control COVID-19 is vaccination. Among the various SARS-CoV-2 vaccines, inactivated virus vaccines have been widely applied in China and many other countries. To understand the underlying protective mechanism of the…

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters Open

Zhaowei Xu, Yang Li, Qing Lei, Likun Huang, Dan‐yun Lai , et al. · 2021

Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, di…

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters Open

Zhaowei Xu, Yang Li, Qing Lei, Likun Huang, Dan‐yun Lai , et al. · 2021

Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, di…

SARS-CoV-2 spike linear epitope scanning via a peptide microarray through sera profiling Open

Yang Li, Dan‐yun Lai, Sheng‐ce Tao · 2021

Antibody landscape against SARS-CoV-2 reveals significant differences between non-structural/accessory and structural proteins Open

Yang Li, Zhaowei Xu, Qing Lei, Dan‐yun Lai, Hongyan Hou , et al. · 2021

Systematic profiling of SARS-CoV-2-specific IgG epitopes at amino acid resolution Open

Huan Qi, Ming‐liang Ma, He‐wei Jiang, Jianya Ling, Lingyun Chen , et al. · 2021

Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients Open

Yang Li, Ming‐liang Ma, Qing Lei, Feng Wang, Wei Hong , et al. · 2021

Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients Open

Yang Li, Dan‐yun Lai, Qing Lei, Zhaowei Xu, Feng Wang , et al. · 2021

Antibody Landscape Against SARS-CoV-2 Proteome Revealed Significant Differences between Non-Structural/ Accessory Proteins and Structural Proteins Open

Yang Li, Zhaowei Xu, Qing Lei, Dan‐yun Lai, Hongyan Hou , et al. · 2021

SARS-CoV-2 Antibody Signatures for Predicting the Outcome of COVID-19 Open

Qing Lei, Caizheng Yu, Yang Li, Hongyan Hou, Zhaowei Xu , et al. · 2021

Antibody landscape against SARS-CoV-2 proteome revealed significant differences between non-structural/ accessory proteins and structural proteins Open

Yang Li, Zhaowei Xu, Qing Lei, Dan‐yun Lai, Hongyan Hou , et al. · 2020

Summary The immunogenicity of SARS-CoV-2 proteome is largely unknown, especially for non-structural proteins and accessory proteins. Here we collected 2,360 COVID-19 sera and 601 control sera. We analyzed these sera on a protein microarray…

Assessment and comparison of recombinant proteins from different sources for the detection of SARS-CoV-2 infection by using protein microarray Open

Huan Qi, Ming‐liang Ma, Dan‐yun Lai, Yang Li, Fucheng Zhang , et al. · 2020

Antibody dynamics to SARS‐CoV‐2 in asymptomatic COVID‐19 infections Open

Qing Lei, Yang Li, Hong‐yan Hou, Feng Wang, Zhuqing Ouyang , et al. · 2020

Background The missing asymptomatic COVID‐19 infections have been overlooked because of the imperfect sensitivity of the nucleic acid testing (NAT). Globally understanding the humoral immunity in asymptomatic carriers will provide scientif…

Systematic profiling of SARS-CoV-2 specific IgG epitopes at single amino acid resolution Open

Huan Qi, Ming‐liang Ma, He‐wei Jiang, Jianya Ling, Lingyun Chen , et al. · 2020

SARS-CoV-2 specific IgG responses play critical roles for patients to recover from COVID-19, in-depth dissecting of the IgG responses on systems level is of great interest. Herein, we adopted a newly developed high-throughput epitope mappi…

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients Open

Yang Li, Dan‐yun Lai, Hainan Zhang, He‐wei Jiang, Xiaolong Tian , et al. · 2020

ARS-CoV-2 outbreak is a world-wide pandemic. The Spike protein plays central role in cell entry of the virus, and triggers significant immuno-response. Our understanding of the immune-response against S protein is still very limited. Herei…

Systematic evaluation of SARS-CoV-2 spike protein derived peptides for diagnosis of COVID-19 patients Open

Yang Li, Dan‐yun Lai, Qing Lei, Zhaowei Xu, Hongyan Hou , et al. · 2020

Serological test plays an essential role in monitoring and combating COVID-19 pandemic. Recombinant spike protein (S protein), especially S1 protein is one of the major reagents for serological tests. However, the high cost in production o…

Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients Open

Yang Li, Ming‐liang Ma, Qing Lei, Feng Wang, Dan‐yun Lai , et al. · 2020

Neutralization antibodies and vaccines for treating COVID-19 are desperately needed. For precise development of antibodies and vaccines, the key is to understand which part of SARS-CoV-2 Spike protein is highly immunogenic on a systematic …

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