Daolong Dou
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View article: FL7 is an ancient ABA-independent inhibitor of PP2C-As regulating plant stress responses
FL7 is an ancient ABA-independent inhibitor of PP2C-As regulating plant stress responses Open
Clade A protein phosphatase 2Cs (PP2C-As) play crucial roles in plant stress responses. Although the ABA receptors PYLs inhibit PP2C-As in an ABA-dependent manner, other modulators of these phosphatases remain largely unknown. Here, we ide…
View article: Uncovering Convergent Pattern Recognition Receptors Recognising <i>Phytophthora</i> Across Plant Lineages
Uncovering Convergent Pattern Recognition Receptors Recognising <i>Phytophthora</i> Across Plant Lineages Open
Pattern recognition receptors (PRRs) are pivotal for plant immunity, yet their discovery in crops is hindered by lineage‐specific divergence. We demonstrate that microbe‐associated molecular patterns (MAMPs) often activate immunity through…
View article: Functional analysis of RALF peptides in soybean immunity and disease resistance
Functional analysis of RALF peptides in soybean immunity and disease resistance Open
Plant cell-surface-localized pattern-recognition receptors (PRRs) recognize conserved microbial patterns to activate pattern-triggered immunity (PTI), which confers mild and broad-spectrum resistance to most microbes. Rapid alkalinization …
View article: A CNL protein forms an NLR pair with NRCX to modulate plant immunity
A CNL protein forms an NLR pair with NRCX to modulate plant immunity Open
Nucleotide-binding leucine-rich repeat (NLR) proteins assemble into genetically linked pairs to mediate effector-triggered immunity (ETI) in plants. Here, we characterize the paired NLRs NRCX and NARY (NRCX adjacent resistance gene Y) in N…
View article: A pair of <scp>GPI</scp>‐anchored proteins regulate soybean immunity and disease resistance in coordination with <scp>GmLMM1</scp> and <scp>GmRALFs</scp>
A pair of <span>GPI</span>‐anchored proteins regulate soybean immunity and disease resistance in coordination with <span>GmLMM1</span> and <span>GmRALFs</span> Open
Summary Plant cell‐surface‐localized pattern recognition receptors and co‐receptors recognize conserved microbial patterns to initiate pattern‐triggered immunity (PTI), which confers moderate and broad‐spectrum resistance to most pathogens…
View article: <i>Solanum bulbocastanum</i> nucleotide‐binding leucine‐rich repeat receptor evolution reveals functional variants and critical residues in Rpi‐blb1/RB
<i>Solanum bulbocastanum</i> nucleotide‐binding leucine‐rich repeat receptor evolution reveals functional variants and critical residues in Rpi‐blb1/RB Open
Host–pathogen co‐evolution shapes resistance ( R ) proteins and their recognition of pathogen avirulence factors. However, little attention has been paid to naturally occurring genetic diversity in R genes. In this study, 12 Solanum bulboc…
View article: Reciprocal phosphorylation between SOAK1 and SOBIR1 fine-tunes receptor-like protein (RLP)–mediated plant immunity
Reciprocal phosphorylation between SOAK1 and SOBIR1 fine-tunes receptor-like protein (RLP)–mediated plant immunity Open
SUPPRESSOR OF BIR1-1 (SOBIR1) is a receptor-like kinase (RLK) that acts as a coreceptor for multiple receptor-like proteins (RLPs) to mediate pathogen-associated molecular pattern)–triggered immunity. However, the regulation of SOBIR1 home…
View article: Deep Learning-Assisted Design for High-Q-Value Dielectric Metasurface Structures
Deep Learning-Assisted Design for High-Q-Value Dielectric Metasurface Structures Open
Optical sensing technologies play a crucial role in various fields such as biology, medicine, and food safety by measuring changes in material properties, such as the refractive index, light absorption, and scattering. Dielectric metasurfa…
View article: Potato DMP2 positively regulates plant immunity by modulating endoplasmic reticulum homeostasis
Potato DMP2 positively regulates plant immunity by modulating endoplasmic reticulum homeostasis Open
Maintenance of endoplasmic reticulum (ER) homeostasis is central for plants to survive in changing cellular and environmental conditions. Although the role of ER in plant immunity is evident, how ER homeostasis is associated with activatio…
View article: A typical NLR recognizes a family of structurally conserved effectors to confer plant resistance against adapted and non-adapted Phytophthora pathogens
A typical NLR recognizes a family of structurally conserved effectors to confer plant resistance against adapted and non-adapted Phytophthora pathogens Open
Plants possess remarkably durable resistance against non-adapted pathogens in nature. However, the underlying molecular mechanisms remain poorly understood, and it is unclear how the resistance is maintained without coevolution between hos…
View article: Blocking the isoflavone chemoreceptor in <i>Phytophthora sojae</i> to prevent disease
Blocking the isoflavone chemoreceptor in <i>Phytophthora sojae</i> to prevent disease Open
Inhibiting pathogen chemotaxis is a promising strategy for reducing disease pressure. However, this strategy is currently in the proof-of-concept stage. Here, Phytophthora sojae was used as a model, as its biflagellated zoospores could sen…
View article: Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer
Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer Open
Our study demonstrated that the novel bio-nanoplatform GDNPs@ICG enhanced the photo-mediated therapeutic effect in breast tumor. GDNPs@ICG could be an alternative for precise and efficient anti-tumor phototherapy.
View article: Global regulatory considerations and practices for tumorigenicity evaluation of cell-based therapy
Global regulatory considerations and practices for tumorigenicity evaluation of cell-based therapy Open
Cell-based therapy, as a "living drug", possesses inherent complexity and heterogeneity. Tumorigenicity evaluation is a crucial aspect of safety assessment for cell-based therapies. Stem cell-based therapies such as hESCs and hiPSCs, may c…
View article: Case Report: A rare diffuse mitral valvular myxoma
Case Report: A rare diffuse mitral valvular myxoma Open
Cardiac myxoma is a common benign tumor, however, myxoma extensively distributed on the mitral valve is rare and seldom reported. A patient who presented with exertional dyspnea and chest tightness was examined by transthoracic and transes…
View article: A receptor kinase senses sterol by coupling with elicitins in auxotrophic <i>Phytophthora</i>
A receptor kinase senses sterol by coupling with elicitins in auxotrophic <i>Phytophthora</i> Open
Sterols are vital nutrients and signals for eukaryotic organisms. Mammalian cells are known to sense and respond to sterol status changes to maintain them within strict limits, a process associated with various human diseases. However, thi…
View article: Phosphorylation of PIP2;7 by CPK28 or Phytophthora kinase effectors dampens pattern-triggered immunity in Arabidopsis
Phosphorylation of PIP2;7 by CPK28 or Phytophthora kinase effectors dampens pattern-triggered immunity in Arabidopsis Open
Plasma membrane intrinsic proteins (PIPs), a subclass of aquaporins, play an important role in plant immunity by acting as H2O2 transporters. Their homeostasis is mostly maintained by C-terminal serine phosphorylation. However, the kinases…
View article: Current Status of Yam Diseases and Advances of Their Control Strategies
Current Status of Yam Diseases and Advances of Their Control Strategies Open
Yam (Dioscorea spp.) is an important tuber crop consumed globally. However, stable yam production faces challenges from a variety of diseases caused by fungi, nematodes, viruses, and bacteria. Prominent diseases such as anthracnose, leaf s…
View article: PUB40 attenuates Phytophthora capsici resistance by destabilizing the MEK2-SIPK/WIPK cascade in Nicotiana benthamiana
PUB40 attenuates Phytophthora capsici resistance by destabilizing the MEK2-SIPK/WIPK cascade in Nicotiana benthamiana Open
The mitogen-activated protein kinase (MAPK) cascade MEK2-SIPK/WIPK is essential for immunity in Solanaceae plants. This cascade is tightly controlled to prevent harmful hyperactivation. However, the E3 ubiquitin ligases utilized by plants …
View article: A <scp>MYB</scp> ‐related transcription factor regulates effector gene expression in an oomycete pathogen
A <span>MYB</span> ‐related transcription factor regulates effector gene expression in an oomycete pathogen Open
Phytophthora pathogens possess hundreds of effector genes that exhibit diverse expression patterns during infection, yet how the expression of effector genes is precisely regulated remains largely elusive. Previous studies have identified …
View article: Joint application of plant immunity-inducing elicitors and fungicides to control Phytophthora diseases
Joint application of plant immunity-inducing elicitors and fungicides to control Phytophthora diseases Open
Phytophthora are destructive plant pathogens that pose a serious threat to crop production. Traditional control methods rely heavily on chemical fungicides, which are harmful to the environment and human health. Currently, effective green …
View article: A pair of soybean malectin-like domain-containing receptor-like kinases jointly regulate pattern-triggered immunity by forming hetero-oligomers
A pair of soybean malectin-like domain-containing receptor-like kinases jointly regulate pattern-triggered immunity by forming hetero-oligomers Open
Plant cells perceive pathogen invasion by recognizing microbial patterns using plasma-membrane-localized pattern-recognition receptors (PRRs) to initiate pattern-triggered immunity (PTI), which confers a moderate immunity to most microbes.…
View article: Plant genes related to Phytophthora pathogens resistance
Plant genes related to Phytophthora pathogens resistance Open
Plants have evolved a multilayered and sophisticated immune system to establish effective resistance to a variety of pathogens. Phytophthora species are among the most notorious plant pathogens, causing destructive diseases on a variety of…
View article: A catalogue of virulence strategies mediated by phytopathogenic effectors
A catalogue of virulence strategies mediated by phytopathogenic effectors Open
Plant diseases cause dramatic economic loss, posing a major challenge to modern agriculture. Plant pathogenic organisms secret effectors that utilize fascinating and intricate stratagems to facilitate infection. The consequences of plant-p…
View article: PcLRR-RK3, an LRR receptor kinase is required for growth and <i>in-planta</i> infection processes in <i>Phytophthora capsici</i>
PcLRR-RK3, an LRR receptor kinase is required for growth and <i>in-planta</i> infection processes in <i>Phytophthora capsici</i> Open
Receptor protein kinases (RPKs) critically provide the basic infrastructure to sense, perceive, and conduct the signalling events at the cell surface of organisms. The importance of LRR-RLKs has been well studied in plants, but much less i…