Daoud Sheban
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View article: Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming
Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming Open
Genomic imprinting secures parent-specific gene expression through differential DNA methylation at imprinted control regions (ICRs). However, how unmethylated imprinted alleles resist de novo methylation remains unclear. Using an allelic m…
View article: Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells
Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells Open
The recent derivation of human trophoblast stem cells (TSCs) from placental cytotrophoblasts and blastocysts opened opportunities for studying the development and function of the human placenta. Recent reports have suggested that human naï…
View article: Histone degradation by the proteasome regulates chromatin and cellular plasticity
Histone degradation by the proteasome regulates chromatin and cellular plasticity Open
Histones constitute the primary protein building blocks of the chromatin and play key roles in the dynamic control of chromatin compaction and epigenetic regulation. Histones are regulated by intricate mechanisms that alter their functiona…
View article: Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency
Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency Open
Different conditions have been devised to isolate MEK/ERK signalling independent human naïve pluripotent stem cells (PSCs) that are distinct from conventional primed PSCs and better correspond to pre-implantation developmental stages. Whil…
View article: Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naïve Pluripotency
Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naïve Pluripotency Open
The Nucleosome Remodeling and Deacytelase (NuRD) complex is a co-repressive complex involved in many pathological and physiological processes in the cell. Previous studies have identified one of its components, Mbd3, as a potent inhibitor …
View article: High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency
High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency Open
The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) with four transcription factors Oct4, Sox2, Klf4 and cMyc (abbreviated as OSKM) 1 has provoked interest to define the molecular characteristics of this proc…