Explanipedia

B-030 Establishment of Concentration-Specific Hemolysis Thresholds for the New Roche Bilirubin Direct Gen.2 Assay and Investigation of Dilution as a Possible Mitigation Strategy for Hemolyzed Specimens Open

Brandon Kelley, Michael A. Lasho, Amy M. Wockenfus, N Baumann, Darci R Block , et al. · 2025

Background Hemolysis, a common pre-analytical interferent in clinical laboratory testing, can significantly affect accuracy and reliability of laboratory results. One test particularly susceptible to interference is direct bilirubin (D-bil…

A-069 Comparison of Three Hemoglobin A1c Methodologies in Variant and Non-Variant Samples Open

Christopher L. Rosemark, Michael Nicklas, Christine L.H. Snozek, Baumann Nikola, Darci R Block · 2025

Background Hemoglobin A1c is used to assess glycemic control to both diagnose and monitor diabetes mellitus. Several different methodologies are available including high performance liquid chromatography (HPLC), capillary electrophoresis (…

Comparison of Five Common Analyzers in the Measurement of Chemistry Analytes in an Authentic Cohort of Body Fluid Specimens Open

Darci R Block, Steven W. Cotten, Deanna Franke, Michael M. Mbughuni · 2025

OBJECTIVES: Interpretation of body fluid (BF) results is based on published studies and clinical guidelines. The aim of this study is to determine whether the assays from five common commercial vendors produce similar results in BFs for 12…

Corrigendum to: Comparison of Five Common Analyzers in the Measurement of Chemistry Analytes in an Authentic Cohort of Body Fluid Specimens Open

Darci R Block, Steven W. Cotten, Deanna Franke, Michael M. Mbughuni · 2025

Corrigendum to "Comparison of Five Common Analyzers in the Measurement of Chemistry Analytes in an Authentic Cohort of Body Fluid Specimens"

The Global Prevalence of Iron Deficiency in Collegiate Athletes: A Systematic Review and Meta‐Analysis Open

Christineil Thompson, Darci R Block, Zhen Wang, Nathan R. Foster, Leslie C. Hassett , et al. · 2024

Athletes are at high risk of iron deficiency even without anemia. In this systematic review and meta‐analysis that included 17,519 athletes in 122 references from 23 countries, participating in 62 unique sports over a 41‐year timeframe, ap…

Iron Deficiency in Collegiate Athletes Obtaining Preparticipation Hemoglobinopathy Screening in the Upper Midwest Open

Christineil Thompson, Eugenia Trushina, DeLisa Fairweather, Darci R Block, Zhen Wang , et al. · 2024

Objective Iron and other biologically important metals are essential to mitochondrial function but are not routinely evaluated. Their equilibrium is critical to the optimal performance of cells with high metabolic activity such as neurons,…

A-111 There is More to Diluting Icterus Interference than Meets the Eye Open

Michael A. Lasho, N Baumann, Darci R Block · 2023

Background Total protein is measured in serum and body fluids as part of routine evaluations of general nutritional status and differentiating exudative and transudative effusions. Spectral interference thresholds for bilirubin (e.g., icte…

A-189 Volume Matters: Continuous Improvement to Reduce Blood Collection Volumes and Collection Tube Utilization Open

Erin A Hain, B K Hendrix, Amy J. Stelpflug, Eileen A. Elliott, S A Boedecker , et al. · 2023

Background Clinical laboratories are constantly changing with automated analyzers and total lab automation (TLA) implemented and replaced over time. Some benefits of newer technologies include decreased specimen volume requirements, less n…

A-335 Pediatric Cortisol Reference Intervals (RI): Impact of Age-Specific RI on the Rate of Abnormal “Low” Cortisol Results Open

B D Andress, Darci R Block, N Baumann · 2023

Background Serum cortisol, measured by automated immunoassay, is a rapid test used for the initial assessment of adrenal dysfunction. Physiologic serum cortisol concentrations are influenced by many factors including diurnal variation, str…

A-122 Fluid Type (STILL) Matters: An Analysis of Quality Control Material Suitability for Measuring Eleven Body Fluid Analytes in the Clinical Laboratory Open

Ria Fyffe-Freil, N Baumann, Darci R Block · 2023

Background Measuring the concentration of albumin, amylase, bilirubin, cholesterol, creatinine, glucose, lactate dehydrogenase (LDH), lipase, total protein(TP), triglycerides, and urea nitrogen(UN) in body fluids(BFs) provides important in…

Population-Based Evaluation of Total Protein in Cerebrospinal Fluid Open

Kalli J. Fautsch, Darci R Block, Jonathan Graff‐Radford, Rui Wang, Emily C. Craver , et al. · 2023

Commentary on A Patient with Third-Space Fluid Loss Open

Darci R Block · 2023

concentration decreased, indicating a myeloma treatment response with subsequent resolution of ascites.

Clinical Laboratory Informatics and Analytics: Challenges and Opportunities Open

Sarah Wheeler, Darci R Block, Dustin R. Bunch, Jamie Gramz, Edward Ki Yun Leung , et al. · 2022

The American Medical Informatics Association defines biomedical and health informatics as the “science of how to use data, information, and knowledge to improve human health and the delivery of health care services.” More specifically with…

<i>Clinical Chemistry</i>’s Invited Reviewers 2022 Open

Kristin Moberg, Aakre Archana, Monica Agarwal, Sean Agbor-Enoh, Shafqat Ahmad , et al. · 2022

Journal Article Clinical Chemistry’s Invited Reviewers 2022 Get access Clinical Chemistry, Volume 68, Issue 12, December 2022, Pages 1585–1586, https://doi.org/10.1093/clinchem/hvac181 Published: 06 December 2022 Article history Received: …

Corrigendum to: Comparison of Five Common Analyzers in the Measurement of Chemistry Analytes in an Authentic Cohort of Body Fluid Specimens Open

Darci R Block, Steven W. Cotten, Deanna Franke, Michael M. Mbughuni · 2022

The Biological Variability of Plasma Ceramides in Healthy Subjects Open

Paola Ramos, Sarah M. Jenkins, Leslie J. Donato, Stacy Hartman, Amy K. Saenger , et al. · 2022

Background Ceramides are bioactive lipid species that mediate numerous cell-signaling events. Elevated plasma ceramides concentration constitutes a risk factor for several pathologies. Multiple studies have affirmed the plasma concentratio…

Investigation of the correlation between immature reticulocyte fraction and reticulocyte hemoglobin content with common tests for iron deficiency anemia Open

Nicholas E. Larkey, Christopher L. Rosemark, Darci R Block · 2021

Reticulocyte hemoglobin content (Ret-He, the hemoglobin within reticulocytes or immature red blood cells) and immature reticulocyte fraction (IRF, the immature fraction of the absolute-reticulocyte-count) are tests that provide insight int…

Biological Variability of Small Dense LDL, HDL3, and Triglyceride-Rich Lipoprotein Cholesterol Open

Erica M. Fatica, Sarah Howard Jenkins, Renee Scott, Darci R Block, Jeffrey W. Meeusen , et al. · 2021

The guideline-recommended lipid panel for cardiovascular disease (CVD) risk assessment measures total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, and calculated low-density lipoprotein (LDL) cholesterol. Measure…

NEJM Knowledge+/AACC Learning Lab Contributors 2021 Open

Jude Abadie, Roger L. Bertholf, Ruth D. Neill, Carey Cotten, A C Deacon , et al. · 2021

COVID-19 Mortality Prediction From Deep Learning in a Large Multistate Electronic Health Record and Laboratory Information System Data Set: Algorithm Development and Validation Open

Saranya Sankaranarayanan, Jagadheshwar Balan, Jesse R. Walsh, Yanhong Wu, Sara Minnich , et al. · 2021

Background COVID-19 is caused by the SARS-CoV-2 virus and has strikingly heterogeneous clinical manifestations, with most individuals contracting mild disease but a substantial minority experiencing fulminant cardiopulmonary symptoms or de…

COVID-19 Mortality Prediction From Deep Learning in a Large Multistate Electronic Health Record and Laboratory Information System Data Set: Algorithm Development and Validation (Preprint) Open

Saranya Sankaranarayanan, Jagadheshwar Balan, Jesse R. Walsh, Yanhong Wu, Sara Minnich , et al. · 2021

BACKGROUND COVID-19 is caused by the SARS-CoV-2 virus and has strikingly heterogeneous clinical manifestations, with most individuals contracting mild disease but a substantial minority experiencing fulminant cardiopulmonary symptoms or d…

Comparative analysis of 23 synovial fluid biomarkers for hip and knee periprosthetic joint infection detection Open

Katyayini Sharma, Morgan I. Ivy, Darci R Block, Matthew P. Abdel, Arlen D. Hanssen , et al. · 2020

There is interest in novel synovial fluid biomarkers for the detection of periprosthetic joint infection (PJI). Here, we assessed the diagnostic accuracy of 23 simple or sophisticated synovial fluid biomarkers for periprosthetic hip or kne…

Proposed Plasma Ammonia Reference Intervals in a Reference Group of Hospitalized Term and Preterm Neonates Open

Theresa Madigan, Darci R Block, William A. Carey, Bethany D. Kaemingk, Robin Patel · 2020

Background Plasma ammonia is commonly measured in the diagnostic evaluation of hospitalized newborns, but reference values are not well defined. Methods We prospectively enrolled newborns admitted to the level III/IV neonatal intensive car…

NEJM Knowledge+/AACC Learning Lab Contributors 2019 Open

Aasne K. Aarsand, Jude Abadie, Alicia Algeciras, David Alter, Fred S. Apple , et al. · 2019

Clinical Validation of Fecal Electrolytes for Chronic Diarrhea Open

Kornelia Galior, John C. Lieske, Darci R Block · 2018

Fecal electrolytes are measured to help narrow the differential diagnosis for chronic diarrhea, defined as symptoms lasting more than 4 weeks. Our laboratory offers a comprehensive panel that includes measurement of chloride, magnesium, os…

Managing Spectral Interferences Using Optical Coagulation Methods Open

Kendall W Cradic, Chris Rosemark, Darci R Block, N Baumann · 2018

Both mechanical and optical-based methods are available for measuring prothrombin time (PT) and activated partial thromboplastin time (aPTT). When optical methods are used, interference from hemolysis, lipemia, and icterus is a concern. He…

45 Human Chorionic Gonadotropin (hCG) Heterophile Interference Investigations: Experience from a Referral Laboratory Open

J.C. Aguirre, Darci R Block, N Baumann, Alicia Algeciras‐Schimnich · 2018

hCG quantification by immunoassay is useful in the evaluation of pregnancy and monitoring of gestational trophoblastic diseases and tumors such a germ cell tumors. Heterophile antibody (HA) interference can cause falsely elevated hCG leadi…

Laboratory Utilization and Analytical Validation of Fecal Electrolyte Tests Open

Rugvedita Parakh, Dina N. Greene, Patrick C. Mathias, Darci R Block, Pratistha Ranjitkar · 2017

Background Chronic diarrhea can be categorized as fatty, watery, or inflammatory. Watery diarrhea is further divided into secretory or osmotic types and can be differentiated by measuring fecal electrolytes and osmotic gap. However, with w…

Determining the Effects of Hemolysis from Blood Contamination on CSF Electrophoresis Results Open

Lusia Sepiashvili, Kari M. Gurtner, Amanda Pappas, Sherwin Chanakarnjanachai, Melissa R. Snyder , et al. · 2017

Pediatric Phlebotomy Services: Optimizing Sample Quality and Improving the Patient and Parent Experience Open

Darci R Block, Twyla M Rickard, Sharon R. Johnson, Laurie D Griesmann, Nicole S. Kang · 2017

The pediatric phlebotomy staff at every medical institution that serves children and babies meets challenges every day. After all, they are responsible for performing a procedure on one of our largest and most vulnerable populations that i…

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