Dario Bressan
YOU?
Author Swipe
View article: Robust consensus nuclear and cell segmentation
Robust consensus nuclear and cell segmentation Open
Cell segmentation is a crucial step in numerous biomedical imaging endeavors—so much so that the community is flooded with publicly available, state-of-the-art segmentation techniques ready for out-of-the-box use. Assessing the strengths a…
View article: Robust Consensus Nuclear and Cell Segmentation
Robust Consensus Nuclear and Cell Segmentation Open
Cell segmentation is a crucial step in numerous biomedical imaging endeavors; so much so that the community is flooded with publicly available, state-of-the-art segmentation techniques ready for out of the box use. Assessing the virtues an…
View article: Consortium Author List from Cancer Research in the Age of Spatial Omics: Lessons from IMAXT
Consortium Author List from Cancer Research in the Age of Spatial Omics: Lessons from IMAXT Open
IMAXT Consortium Author List
View article: Data from Cancer Research in the Age of Spatial Omics: Lessons from IMAXT
Data from Cancer Research in the Age of Spatial Omics: Lessons from IMAXT Open
Summary:The Imaging and Molecular Annotation of Xenografts and Tumors Cancer Grand Challenges team was set up with the objective of developing the “next generation” of pathology and cancer research by using a combination of single-cell and…
View article: Consortium Author List from Cancer Research in the Age of Spatial Omics: Lessons from IMAXT
Consortium Author List from Cancer Research in the Age of Spatial Omics: Lessons from IMAXT Open
IMAXT Consortium Author List
View article: HGG-47. SPATIAL SINGLE-CELL PROTEOMIC ANALYSIS MAPS THE DISTINCT PEDIATRIC-TYPE DIFFUSE HIGH-GRADE GLIOMA TUMOR ENTITIES AND DEFINES THEIR TUMOR AND IMMUNE MICROENVIRONMENTS
HGG-47. SPATIAL SINGLE-CELL PROTEOMIC ANALYSIS MAPS THE DISTINCT PEDIATRIC-TYPE DIFFUSE HIGH-GRADE GLIOMA TUMOR ENTITIES AND DEFINES THEIR TUMOR AND IMMUNE MICROENVIRONMENTS Open
Paediatric-type diffuse high-grade gliomas (pDHGG) are a group of molecularly and clinically defined tumor entities of the central nervous system. The investigation of the spatial organization of pDHGG tissues may provide new insights to d…
View article: Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues
Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues Open
Mapping the molecular identities and functions of cells within their spatial context is key to understanding the complex interplay within and between tissue neighbourhoods. A wide range of methods have recently enabled spatial profiling of…
View article: Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole-slide imaging and accurate segmentation
Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole-slide imaging and accurate segmentation Open
Imaging mass cytometry (IMC) is a powerful technique capable of detecting over 30 markers on a single slide. It has been increasingly used for single-cell-based spatial phenotyping in a wide range of samples. However, it only acquires a re…
View article: The dawn of spatial omics
The dawn of spatial omics Open
Spatial omics has been widely heralded as the new frontier in life sciences. This term encompasses a wide range of techniques that promise to transform many areas of biology and eventually revolutionize pathology by measuring physical tiss…
View article: From a genome-wide screen of RNAi molecules against SARS-CoV-2 to a validated broad-spectrum and potent prophylaxis
From a genome-wide screen of RNAi molecules against SARS-CoV-2 to a validated broad-spectrum and potent prophylaxis Open
Expanding the arsenal of prophylactic approaches against SARS-CoV-2 is of utmost importance, specifically those strategies that are resistant to antigenic drift in Spike. Here, we conducted a screen of over 16,000 RNAi triggers against the…
View article: Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole slide imaging with accurate single-cell segmentation
Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole slide imaging with accurate single-cell segmentation Open
Summary Imaging mass cytometry (IMC) is a powerful multiplexed tissue imaging technology that allows simultaneous detection of more than 30 makers on a single slide. It has been increasingly used for singlecell-based spatial phenotyping in…
View article: Dual-modality imaging of immunofluorescence and imaging mass cytometry for high-resolution whole slide imaging with accurate single-cell segmentation
Dual-modality imaging of immunofluorescence and imaging mass cytometry for high-resolution whole slide imaging with accurate single-cell segmentation Open
Imaging mass cytometry (IMC) is a powerful multiplexed tissue imaging technology that allows simultaneous detection of more than 30 makers on a single slide. It has been increasingly used for single-cell based spatial phenotyping in a wide…
View article: Dual-modality imaging of immunofluorescence and imaging mass cytometry for high-resolution whole slide imaging with accurate single-cell segmentation
Dual-modality imaging of immunofluorescence and imaging mass cytometry for high-resolution whole slide imaging with accurate single-cell segmentation Open
Imaging mass cytometry (IMC) is a powerful multiplexed tissue imaging technology that allows simultaneous detection of more than 30 makers on a single slide. It has been increasingly used for single-cell based spatial phenotyping in a wide…
View article: Imaging and Molecular Annotation of Xenographs and Tumours (IMAXT): High throughput data and analysis infrastructure
Imaging and Molecular Annotation of Xenographs and Tumours (IMAXT): High throughput data and analysis infrastructure Open
With the aim of producing a 3D representation of tumors, imaging and molecular annotation of xenografts and tumors (IMAXT) uses a large variety of modalities in order to acquire tumor samples and produce a map of every cell in the tumor an…
View article: Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies Open
Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to therapy has r…
View article: Author response: Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies
Author response: Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Tumour he…
View article: Single-cell genomic variation induced by mutational processes in cancer
Single-cell genomic variation induced by mutational processes in cancer Open
How cell-to-cell copy number alterations that underpin genomic instability 1 in human cancers drive genomic and phenotypic variation, and consequently the evolution of cancer 2 , remains understudied. Here, by applying scaled single-cell w…
View article: Genome wide screen of RNAi molecules against SARS-CoV-2 creates a broadly potent prophylaxis
Genome wide screen of RNAi molecules against SARS-CoV-2 creates a broadly potent prophylaxis Open
Expanding the arsenal of prophylactic approaches against SARS-CoV-2 is of utmost importance, specifically those strategies that are resistant to antigenic drift in Spike. Here, we conducted a screen with over 16,000 RNAi triggers against t…
View article: Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies Open
Tumor heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to therapy has re…
View article: Exploration and analysis of molecularly annotated, 3D models of breast cancer at single-cell resolution using virtual reality
Exploration and analysis of molecularly annotated, 3D models of breast cancer at single-cell resolution using virtual reality Open
A set of increasingly powerful approaches are enabling spatially resolved measurements of growing numbers of molecular features in biological samples. While important insights can be derived from the two-dimensional data that many of these…
View article: The Imaging and Molecular Annotation of Xenografts and Tumours (IMAXT) High Throughput Data and Analysis Infrastructure
The Imaging and Molecular Annotation of Xenografts and Tumours (IMAXT) High Throughput Data and Analysis Infrastructure Open
With the aim of producing a 3D representation of tumours, IMAXT uses a large variety of modalities in order to acquire tumour samples and produce a map of every cell in the tumour and its host environment. With the large volume and variety…
View article: Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems Open
Identifying transcript location in cells Identifying where specific RNAs occur within a cell or tissue has been limited by technology and imaging capabilities. Expansion microscopy has allowed for better visualization of small structures b…