Dario Gelevski
YOU?
Author Swipe
View article: Amyotrophic Lateral Sclerosis Clinical Research Site Operations: Emerging Challenges and Potential Solutions From Multiple Sites in the <scp>US</scp>
Amyotrophic Lateral Sclerosis Clinical Research Site Operations: Emerging Challenges and Potential Solutions From Multiple Sites in the <span>US</span> Open
As the amyotrophic lateral sclerosis (ALS) clinical trial landscape continues to grow and evolve, optimization of research site efficiency is essential. Herein, we outline results from a formal discussion among multiple ALS research sites …
View article: An Expanded Access Protocol of <scp>RNS60</scp> in Amyotrophic Lateral Sclerosis
An Expanded Access Protocol of <span>RNS60</span> in Amyotrophic Lateral Sclerosis Open
Aims RNS60 is an investigational product in clinical development for amyotrophic lateral sclerosis (ALS). RNS60 slowed disease progression in the ALS SOD1 G93A mouse model and was safe and well tolerated both in an open‐label pilot study a…
View article: Expanded access protocol (<scp>EAP</scp>) program for access to investigational products for amyotrophic lateral sclerosis (<scp>ALS</scp>)
Expanded access protocol (<span>EAP</span>) program for access to investigational products for amyotrophic lateral sclerosis (<span>ALS</span>) Open
Introduction/Aims Expanded access protocols (EAPs) are a Food and Drug Administration (FDA)‐regulated pathway for granting access to investigational products (IPs) to individuals with serious diseases who are ineligible for clinical trials…
View article: Randomized trial of inosine for urate elevation in amyotrophic lateral sclerosis
Randomized trial of inosine for urate elevation in amyotrophic lateral sclerosis Open
Introduction/Aims Higher urate levels are associated with improved ALS survival in retrospective studies, however whether raising urate levels confers a survival advantage is unknown. In the Safety of Urate Elevation in Amyotrophic Lateral…
View article: Safety and activity of <scp>anti‐CD14</scp> antibody <scp>IC14</scp> (atibuclimab) in <scp>ALS</scp>: Experience with expanded access protocol
Safety and activity of <span>anti‐CD14</span> antibody <span>IC14</span> (atibuclimab) in <span>ALS</span>: Experience with expanded access protocol Open
Introduction/Aims IC14 (atibuclimab) is a monoclonal anti‐CD14 antibody. A previous phase 1 trial of 10 participants with amyotrophic lateral sclerosis (ALS) demonstrated initial safety of IC14 in an acute treatment setting. We provided lo…
View article: An expanded access protocol of <scp>RT001</scp> in amyotrophic lateral sclerosis—Initial experience with a lipid peroxidation inhibitor
An expanded access protocol of <span>RT001</span> in amyotrophic lateral sclerosis—Initial experience with a lipid peroxidation inhibitor Open
Introduction/Aims Lipid peroxidation is thought to play a biologically important role in motor neuron death in amyotrophic lateral sclerosis (ALS). 11,11 Di‐deuterated linoleic ethyl ester (RT001) prevents lipid peroxidation in cellular an…
View article: Towards large‐scale steady‐state enhanced nuclear magnetization with in situ detection
Towards large‐scale steady‐state enhanced nuclear magnetization with in situ detection Open
Signal amplification by reversible exchange (SABRE) boosts NMR signals of various nuclei enabling new applications spanning from magnetic resonance imaging to analytical chemistry and fundamental physics. SABRE is especially well positione…
View article: Towards Large-Scale Steady-State Enhanced Nuclear Magnetization with In Situ Detection
Towards Large-Scale Steady-State Enhanced Nuclear Magnetization with In Situ Detection Open
Signal Amplification By Reversible Exchange (SABRE) boosts NMR signals of various nuclei enabling new applications spanning from magnetic resonance imaging to analytical chemistry and fundamental physics. SABRE is especially well positione…
View article: Towards Large-Scale Steady-State Enhanced Nuclear Magnetization with In Situ Detection
Towards Large-Scale Steady-State Enhanced Nuclear Magnetization with In Situ Detection Open
Signal Amplification By Reversible Exchange (SABRE) boosts NMR signals of various nuclei enabling new applications spanning from magnetic resonance imaging to analytical chemistry and fundamental physics. SABRE is especially well positione…