Dario Saczko-Brack
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View article: Cardiolipin membranes drive Myosin VI activation, oligomerization, and processive cargo transport
Cardiolipin membranes drive Myosin VI activation, oligomerization, and processive cargo transport Open
Mitochondrial damage determines cell fate, leading to mitochondrial autophagy or cellular apoptosis in health and disease. The molecular mechanisms and role of the acto-myosin cytoskeleton regulating mitochondrial clearance and membrane re…
View article: Reconstitution reveals how myosin-VI self-organises to generate a dynamic mechanism of membrane sculpting
Reconstitution reveals how myosin-VI self-organises to generate a dynamic mechanism of membrane sculpting Open
One enigma in biology is the generation, sensing and maintenance of membrane curvature. Curvature-mediating proteins have been shown to induce specific membrane shapes by direct insertion and nanoscopic scaffolding, while the cytoskeletal …
View article: Self-organization of actin networks by a monomeric myosin
Self-organization of actin networks by a monomeric myosin Open
Significance Actomyosin networks are central to a broad range of cellular motile processes, including cell polarization and collective cell migration during morphogenesis and development. Myosin-IXa is critically involved in these processe…