Darius Camp
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View article: The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion
The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion Open
Cell adhesion requires linkage of transmembrane receptors to the cytoskeleton through intermediary linker proteins. Integrin-based adhesion to the extracellular matrix (ECM) involves large adhesion complexes that contain multiple cytoskele…
View article: Gap junctions mediate discrete regulatory steps during fly spermatogenesis
Gap junctions mediate discrete regulatory steps during fly spermatogenesis Open
Gametogenesis requires coordinated signaling between germ cells and somatic cells. We previously showed that Gap junction (GJ)-mediated soma-germline communication is essential for fly spermatogenesis. Specifically, the GJ protein Innexin4…
View article: Direct binding of Talin to Rap1 is required for cell–ECM adhesion in <i>Drosophila</i>
Direct binding of Talin to Rap1 is required for cell–ECM adhesion in <i>Drosophila</i> Open
Attachment of cells to the extracellular matrix (ECM) via integrins is essential for animal development and tissue maintenance. The cytoplasmic protein Talin (encoded by rhea in flies) is necessary for linking integrins to the cytoskeleton…
View article: Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo
Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo Open